Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 0 0 2025 01 05 1017 1017 Ghazal Etemadi Department of Medical Physics and Biomedical Engineering, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ahmad Mostaar Payam Azadeh Department of Radiation Oncology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Niloofar Yousefi Moteghaed Department of Medical Physics and Biomedical Engineering, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2024 05 25 2024 10 15 Purpose: The phantom-less patient-specific quality assurance (PSQA) for intensity‐modulated radiotherapy (IMRT) plan verification has been exploited recently. The aim of this study was the feasibility of the PSQA of the plan based on a log file and onboard detector for prostate patients in helical tomotherapy. Method: For 15 prostate patients, the quality assurance (QA) of the helical tomotherapy plan was performed using the Delta4 phantom and Cheese phantom to evaluate the spatial dose distribution and point dose, respectively. These parameters were also reconstructed by delivery analysis (DA) software using the measured leaf open times (LOTs). The gamma analysis and relative dose difference were used to compare the measured and reconstructed dose with the calculated values. Then, using the relative discrepancy, the log file and onboard detector data were compared with the expected data to assess machine performance. Results: The mean relative dose difference was within 1.3% among the measurement, reconstruction, and calculation. The results of statistical analysis and p-value showed there is no statistically significant difference in determining the dose difference between the DA-based and conventional QA methods. The gamma values of 3%/3mm, 3%/2mm, 2%/3mm, 2%/2mm, 2%/1mm, and 1%/1mm for the DA-based QA method were the same as the measurement QA method. However, the gamma values of 3%/1mm, 1%/3mm, and 1%/2mm were comparable. The mean percentage difference LOTs was 0.07%, and most differences occurred in very low and some high LOTs. The relative difference was lower than 2.30% for the couch speed, couch movement, monitor unit, and rotation per minute (RPM) gantry between the log file and expected data. Conclusion: The DA software is an efficient alternative to the measurement-based PSQA method. However, the accuracy of the DA software requires further investigations for gamma analysis at strict criteria. The very low and high LOTs may lead to the dose discrepancy. The tomotherapy machine can accurately implement the planned parameters. https://fbt.tums.ac.ir/index.php/fbt/article/view/1017 https://fbt.tums.ac.ir/index.php/fbt/article/download/1017/474