Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 0 0 2025 06 04 1160 1160 EN Mohammad Enferadi-aliabad Department of Medical Physics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mohammad Broomand Department of Radiotherapy, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Abolfazl Nikfarjam Department of Medical Physics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 2024 11 30 2025 02 11 Introduction Laryngeal cancer is a critical health issue, often treated using advanced radiation therapy techniques such as Intensity-Modulated Radiation Therapy (IMRT). The gamma index is a widely used metric for quality assurance in radiotherapy, assessing the agreement between planned and delivered dose distributions. Objective This study aims to evaluate the feasibility and accuracy of laryngeal IMRT treatment plans using three gamma analysis algorithms and varying evaluation parameters, including dose difference (DD%), distance-to-agreement (DTA).   Result Gamma passing rates (GPR) for the laryngeal IMRT plans demonstrated high accuracy, with over 90% of pixels passing the criteria in most cases. Composite gamma analysis showed 53.89% of pixels meeting both DD and DTA criteria simultaneously, while individual evaluation revealed the impact of stricter thresholds on GPR. Subtraction analysis identified dose discrepancies, emphasizing the need for accurate calibration. Conclusion This study highlights the effectiveness of gamma analysis in ensuring the accuracy of IMRT treatment plans for laryngeal cancer. The findings underscore the importance of rigorous PSQA, parameter optimization, and advanced algorithms to enhance treatment precision. https://fbt.tums.ac.ir/index.php/fbt/article/view/1160 https://fbt.tums.ac.ir/index.php/fbt/article/download/1160/507