Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 0 0 2025 04 22 1226 1226 Yalda Alimorad Khoram abad Department of Nuclear physics, Faculty of Basic Sciences, University of Mohaghegh Ardabili, Ardabil, Iran. Zahra Masoumi Verki Department of Biomedical Engineering and Medical Physics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Narjes Sabokro Department of Medical physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 2025 02 14 2025 03 04 Abstract Objective: To evaluate the effectiveness of polymer-based shields containing boron compounds for radiation protection in medical centers, focusing on their performance against neutron and gamma radiation. Methods: A comprehensive literature review was conducted using databases including PubMed, Scopus, Web of Science, and Embase. Studies published from 2010 to February 2025 were included. The search strategy employed keywords related to polymer-based shields, boron compounds, and radiation protection in medical settings. Results: Boron-containing polymers demonstrated significant potential for radiation shielding, particularly against neutrons. Nanocomposites incorporating high-Z elements showed improved gamma radiation attenuation. Hexagonal boron nitride (h-BN) nanocomposites exhibited superior neutron absorption properties. Epoxy-based composites with various nanoparticles showed enhanced protection against both neutron and gamma radiation. Recycled high-density polyethylene (R-HDPE) composites containing gadolinium oxide demonstrated promising thermal neutron shielding capabilities. Conclusion: Polymer-based shields containing boron compounds offer lightweight, flexible, and effective alternatives to traditional shielding materials. These materials show particular promise in medical applications, potentially improving safety for both patients and healthcare providers. However, challenges remain in optimizing material composition, thickness, and long-term stability for practical implementation in clinical settings. https://fbt.tums.ac.ir/index.php/fbt/article/view/1226 https://fbt.tums.ac.ir/index.php/fbt/article/download/1226/498