Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 0 0 2025 04 22 1227 1227 Cobra Ghasemi 1Rehabilitation Research Center, Department of Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran. Fatemeh Taslimi Department of Internal Medicine, School of Medicine, Mazandaran University of Medical Science, Mazandaran, Iran. Zahra Masoumi Verki Department of Biomedical Engineering and Medical Physics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2025 02 16 2025 03 04 Background: This review aims to synthesize current literature on recent advances in the diagnosis and treatment of Brain and spinal cord injuries (SCIs), focusing on molecular imaging, cell therapy, brain-computer interfaces (BCIs), and craniosacral therapy (CST). Methods: A systematic search was conducted in PubMed/MEDLINE, Scopus, Web of Science, Cochrane Library, and Google Scholar to identify relevant articles published between 2015 and 2025. Keywords included "Brain Injury," "Spinal Cord Injury," "Molecular Imaging," "Cell Therapy," "Brain-Computer Interface," and "Craniosacral Therapy." Results: Molecular imaging techniques, such as fMRI, DTI, and PET, enhance diagnostic accuracy by visualizing neural activity and structural integrity. Cell therapy, particularly with mesenchymal stem cells (MSCs), shows promise in promoting axon regeneration and reducing inflammation. BCIs offer potential for restoring motor function and enhancing neural plasticity. The evidence for CST is mixed, with some studies suggesting benefits in pain relief and cognitive improvement, while others raise concerns about methodological limitations. Conclusion: Recent advances in molecular imaging, cell therapy, and BCIs offer promising avenues for improving the diagnosis and treatment of BSCI. However, further rigorous research is needed to validate the efficacy of these approaches and to address ethical considerations. While CST has gained attention as a complementary therapy, more high-quality studies are required to determine its effectiveness. This review highlights the need for interdisciplinary collaboration to translate scientific discoveries into clinical practice and to improve the quality of life for individuals affected by BSCI. https://fbt.tums.ac.ir/index.php/fbt/article/view/1227 https://fbt.tums.ac.ir/index.php/fbt/article/download/1227/497