Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 0 0 2025 10 28 1258 1258 Hanie Arabian Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran. Alireza Karimian Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran Hamid Reza Marateb Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran. Carolina Migliorelli Unit of Digital Health, Eurecat, Centre Tecnològic de Catalunya, 08005 Barcelona, Spain Miquel Mañanas Department of Automatic Control, Biomedical Engineering Research Center, Polytechnic University of Catalonia, BarcelonaTech (UPC), Barcelona, Spain Sergio Romero Department of Automatic Control, Biomedical Engineering Research Center, Polytechnic University of Catalonia, BarcelonaTech (UPC), Barcelona, Spain Antonio Russi Epilepsy Unit, Hospital Quirón Teknon Rafał Nowak Magnetoencephalography Unit, Hospital Quirón Teknon, Barcelona, Spain 2025 04 14 2025 08 18 Purpose: Magnetoencephalography (MEG) is a brain imaging method with a high temporal-spatial resolution by recording neural magnetic fields. The data quality of this imaging method is reduced for reasons such as the failure of one or more sensors. This study aims to explore the efficiency of the various data reconstruction techniques in magnetoencephalography for the retrieval of poor-quality channels. Materials and Methods: We compared three surface reconstruction methods (Mean, Median, and Trimmed mean), two partial differential equations (modified Poisson and Diffusion equation), and a Finite Element-based interpolation method using data from 11 young adults (aged 30±12). Each technique was assessed in terms of time taken for reconstruction, R-squared, root mean squared error (RMSE), and signal-to-noise ratio (SNR) compared to a reference signal. Statistical tests (P-value < 0.05) were used to analyze the relationships between the mentioned evaluation criteria. Generalized Linear Models revealed that surface reconstruction methods and finite-element interpolation outperformed partial differential equations. Results: The Trimmed mean method achieved the highest R-squared (0.882 ± 0.0610) and lowest RMSE (0.0155 ± 0.00904) with a reconstruction time of 9.5154 microseconds for a 500 milliseconds epoch of a magnetoencephalography channel data. Conclusion: The surface reconstruction methods can recover the noisy or lost signal in magnetoencephalography with a suitable error and required time. https://fbt.tums.ac.ir/index.php/fbt/article/view/1258 https://fbt.tums.ac.ir/index.php/fbt/article/download/1258/535