Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 8 1 2021 03 30 42 49 Hamed Karimi Royan Institute for Stem Cell Biology and Technology Haniye Marefat School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM) Mahdiye Khanbagi Royan Institute for Stem Cell Biology and Technology Alireza Karami Center for Mind/Brain Sciences (CIMeC), University of Trento Zahra Vahabi Department of Geriatric Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran 2020 10 11 2020 11 24 Purpose: The process of neurodegeneration in Alzheimer's Disease (AD) is irreversible using current therapeutics. An earlier diagnosis of the disease can lead to earlier interventions, which will help patients sustain their cognitive abilities for longer. Individuals within the early stages of AD, shown to have trouble making confident and sounds decisions. Here we proposed a computational approach to quantify the decision-making ability in patients with mild cognitive impairment and mild AD. Materials and Methods: To study the quantified decision-making abilities at the early stages of the disease, we took advantage of a 2-Alternative Forced-Choice (2AFC) task. We applied the Drift Diffusion Model to determine whether the information accumulation process in a categorization task is altered in patients with mild cognitive impairment and mild AD. We implemented a classification model to detect cognitive impairment based on the Drift Diffusion Model's estimated parameters. Results: The results show a significant correlation of the classification score with the standard pen-and-paper tests, suggesting that the quantified decision-making parameters are undergoing significant change in patients with cognitive impairment. Conclusion: We confirmed that the decision-making ability deteriorates at the early stages of AD. We introduced a computational approach for measuring the decline in decision-making and used that measurement to distinguish patients from healthy individuals. https://fbt.tums.ac.ir/index.php/fbt/article/view/285 https://fbt.tums.ac.ir/index.php/fbt/article/download/285/193