Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 10 4 2023 10 01 459 464 Sahar Seifzadeh Young Researchers and Elite Club, Qazvin Branch, Islamic Azad University, Qazvin, Iran Vahid Asayesh Asayesh Rehabilitation Clinic and Neuro-Psycho-Cognitive index Research Center Majid Torabi Nikjeh Asayesh Rehabilitation Clinic and Neuro-Psycho-Cognitive index Research Center Mahdi Dehghani neuro-psycho-cognitive index research center Elham Rabbani Parsa Department of Psychology, Cognitive Psychology, Semnan University Fatemeh Asgharianasl Department of Psychology, Faculty of Education & Psychology, Azarbaijan Shahid Madani University 2021 06 20 2022 10 09 Autonomous Sensory Meridian Response is a novel phenomenon that is very popular these days on Youtube and Reddit to its anti-anxiety effects. As the name suggests, ASMR is a relaxing warm sensation that begins on the scalp and spreads throughout the body. This technique is also known as "brain massage," and it relies on soothing sights and sounds, like whispers and slow movements.One of the most substantial reasons for investigating these videos is to find out their scientific roots, which can be from different approaches. In this paper, we intended to examine the physiological changes such as Heart Rate (HR) as well as Galvanic Skin Conductance (GSC) levels before and after watching a single session ASMR video. The dependent t-test statistical analysis by SPSS results with P-value <=0.01 indicated that after a single session of ASMR watching, the heart rate decreased significantly comparing the baseline data. In addition, the skin conductance was slightly reduced as well, but not significantly. These physiological findings prove that ASMR could be an affordable, portable, and immediate anxiety relief for those struggling with anxiety-based disorders, especially for patients who do not respond well to medication or seek alternatives to anti-anxiety medications due to the wide range of side effects or would like to try it for better results along with the prescribed drugs.   https://fbt.tums.ac.ir/index.php/fbt/article/view/359 https://fbt.tums.ac.ir/index.php/fbt/article/download/359/306