Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 2 2 2015 06 30 103 108 EN Siavash Mazdeyasna Biomedical Engineering Department, Science and Research Branch of Islamic Azad University. Amir Homayoun Jafari Department of Biophysics & Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, IranAND Research Center for Biomedical Technologies and Robotics (RCBTR), Tehran University of Medical Sciences, Tehran, Iran. Jamshid Hadjati Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Armin Allahverdy Department of Biophysics & Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AND Research Center for Biomedical Technologies and Robotics (RCBTR), Tehran University of Medical Sciences, Tehran, Iran. Mehdi Alavi-Moghaddam Department of Biophysics & Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2015 11 24 2015 11 24 Purpose: Plans for all types of therapies for cancer need to be updated according to new achievements in science and technology. Building models of in vitro cancer cell growth may make a predictive view for physicians about the behavior of these cells in the real world.  Methods: In this study using experimental data which acquired from cultured cells and taking photos using a digital microscope lens, we designed a Cellular Automata model of death and growth of melanoma cancer cells in the presence of different concentration of FBS and different dose of Cisplatin as a chemotherapy drug.  Results: This model is based oncellular automata although we used a genetic algorithm for this model.This combined model casts a dynamic in model and made which is adoptive based on the alternation of the environment. In the end, we achieved up to 75% prediction accuracy about the behavior of these cells.  Conclusion: The proposed model showed approximately good results to predict tumor growth in the presence of different dosages of chemotherapy drug and it can make a perspective of tumor growth for us. https://fbt.tums.ac.ir/index.php/fbt/article/view/51 https://fbt.tums.ac.ir/index.php/fbt/article/download/51/46