Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 1 3 2014 09 30 151 158 EN Sina Houshmand Department of Radiology, University of Pennsylvania, Philadelphia, USA. Saeid Gholami Department of Radiology, University of Pennsylvania, Philadelphia, USA. Ali Salavati Department of Radiology, University of Pennsylvania, Philadelphia, USA. Abass Alavi Department of Radiology, University of Pennsylvania, Philadelphia, USA. 2015 10 13 2015 10 13 Positron emission tomography (PET) has been utilized in numerous aspects of medicine since its introduction and development in 1970s. There has been a rapid improvement in imaging techniques and radiotracers in the last decade, which have enhanced the quality of PET in different biomedical research domains and patient care settings. In this editorial we will discuss applications of PET-computed tomography (CT)/magnetic resonance imaging (MRI) as well as other radiotracers in different variety of malignant and non-malignant diseases such as cardiovascular, central nervous system, inflammatory and systemic diseases and review new concepts applicable to this imaging modality. https://fbt.tums.ac.ir/index.php/fbt/article/view/6 https://fbt.tums.ac.ir/index.php/fbt/article/download/6/5