Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 11 2 2024 03 31 184 190 EN Sayed Mohammad Sakhaei Department of Radiology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Sedighe Rahmani Firouzabadi Department of Radiology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Mohamad Ghazanfari Hashemi cancer institute, tehran university of medical sciences, tehran, iran Seyedeh Nooshin Miratashi Yazdi Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences, Tehran, Iran Mohammad Ali Kaviani Department of Radiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Maryam Alaei School of Medicine, Shahid Beheshti Medical University, Tehran, Iran Helia Helali School of Medicine, Shahid Beheshti Medical University, Tehran, Iran Maedeh Ghazanfari Hashemi School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Marjan Gholami School of Pharmacy, Islamic Azad University Pharmaceutical Sciences Branch, Tehran, Iran Vahid Talebi Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran 2022 12 30 2023 01 23 Purpose: The present study was designed to evaluate the potential efficacy of Multiparametric-Magnetic Resonance Imaging (MP-MRI) in the detection of prostate cancer locations compared to Transrectal Ultrasound (TRUS) guided biopsy, as the gold standard method. Materials and Methods: A total of 66 subjects participated in this cross-sectional study. All individuals underwent MP-MRI imaging before the prostate TRUS. The findings of either method have been investigated and the comparison had been made using the Chi-squared test. Results: The sensitivity and specificity of the MP-MRI in the diagnosis of prostate cancer were 81.8% and 93.9%, respectively. The positive and negative predictive values were 93.1% and 83.8%, respectively. Conclusion: The current study indicates that the MP-MRI imaging method has sufficient sensitivity and specificity for detecting the location of prostate cancer and can potentially be employed as a clue-providing method prior to the TRUS-guided biopsy. https://fbt.tums.ac.ir/index.php/fbt/article/view/624 https://fbt.tums.ac.ir/index.php/fbt/article/download/624/300