Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 11 4 2024 01 31 616 621 EN Mohamad Ghazanfari Hashemi Cancer institute, Department of Radiology, Tehran university of medical sciences, Tehran, Iran Mahsa Vafaei Mastanabad Neurosurgery Department, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Maryam Alaei School of Medicine, Shahid Beheshti Medical University, Tehran, Iran Mohammad Ali Kaviani Department of Radiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Ali Asadifar Department of Radiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Rahim Momivand Oral and Maxillofacial Radiology Department, Hamadan University of Medical Sciences, Hamadan, Iran Helia Helali Department of Psychiatry, School of Medicine, Shahid Beheshti Medical University, Tehran, Iran Maedeh Ghazanfari Hashemi School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Marjan Gholami School of Pharmacy, Islamic Azad University Pharmaceutical Sciences Branch, Tehran, Iran Seyedeh Nooshin Miratashi Yazdi Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences, Tehran, Iran 2023 02 09 2023 05 05 Purpose: Restless legs syndrome is claimed to be associated with a higher risk of cardiovascular diseases. Intima-media thickness has been reported to be the most valuable surrogate marker and predictor of atherosclerosis progression and upcoming cardiovascular diseases. In this study, we aimed to evaluate the relationship between restless legs syndrome and intima-media thickness of the carotid artery. Materials and Methods: In this case-control study, a total of 23 patients with restless legs syndrome without other known risk factors of cardiovascular diseases were evaluated with regard to the intima-media thickness of the carotid artery by employing a high-resolution B-mode ultrasound study. The findings of the ultrasound study between the case and the control group were compared and statistically analyzed. Results: Intima-media thickness was revealed to be of a lower value in subjects with restless legs syndrome (0.79±0.10) compared to the control group (0.88±0.13). Also, our study showed that older age and the presence of hypertension directly correlates with intima-media thickness. Conclusion: It can be concluded that restless legs syndrome is associated with a lower intima-media thickness. https://fbt.tums.ac.ir/index.php/fbt/article/view/652 https://fbt.tums.ac.ir/index.php/fbt/article/download/652/334