Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 11 3 2024 06 01 471 476 Shams Waleed Khalid Department of Pedodontics and preventive dentistry, College of Dentistry, University of Baghdad. Bab-Almoadham, P.O. Box 1417, Baghdad, Iraq Ahlam Taha Mohammed Department of Pedodontics and preventive dentistry, College of Dentistry, University of Baghdad. Bab-Almoadham, P.O. Box 1417, Baghdad, Iraq 2023 05 15 2023 07 16 Purpose: This study aimed to evaluate the effect of total antioxidant capacity on periodontal diseases among ionizing radiation workers. The relationship between oxidative stress and periodontal health in this specific occupational group was assessed to gain insights into potential antioxidant supplementation needs and strategies to promote periodontal well-being. Materials and Methods: This case-control study was conducted among ionizing radiation workers (CT scan section) and control group participants. Salivary samples were collected from both groups, and total antioxidant capacity was measured using an Enzyme-Linked Immunosorbent Assay (ELISA) kit. Clinical periodontal parameters were also assessed. Statistical analysis was performed using T-tests to compare the results between the groups. Results: The study group showed a significantly lower total antioxidant capacity (2.534) compared to the control group (3.806) (p = 0.022). Significant differences were observed in plaque index, probing pocket depth, and clinical attachment loss between the groups. These findings suggest a potential association between radiation exposure, decreased antioxidant capacity, and periodontal tissue damage. Conclusion: Radiographic workers exposed to ionizing radiation had lower antioxidant capacity and higher rates of periodontal diseases. Maintaining adequate antioxidants is crucial for protecting periodontal tissues. Further research should investigate mechanisms and exposure variations. https://fbt.tums.ac.ir/index.php/fbt/article/view/710 https://fbt.tums.ac.ir/index.php/fbt/article/download/710/425