Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 12 2 2025 03 01 219 228 Mohammadreza Ansari Astaneh Eye Research Center, Mashhad University of Medical Sciences, Khatam Al-Anbia Eye Hospital, Gharani Boulevard, Mashhad, Iran Nasim Shahsavan Gharbi Eye Research Center, Mashhad University of Medical Sciences, Khatam Al-Anbia Eye Hospital, Gharani Boulevard, Mashhad, Iran Mojtaba Abrishami Eye Research Center, Mashhad University of Medical Sciences, Khatam Al-Anbia Eye Hospital, Gharani Boulevard, Mashhad, Iran Elham Bakhtiari Eye Research Center, Mashhad University of Medical Sciences, Khatam Al-Anbia Eye Hospital, Gharani Boulevard, Mashhad, Iran Mehrdad Motamed Shariati Eye Research Center, Mashhad University of Medical Sciences, Khatam Al-Anbia Eye Hospital, Gharani Boulevard, Mashhad, Iran 2023 07 19 2023 09 02 Purpose: This study used Optical Coherence Tomography Angiography (OCTA) to examine the progression of the macular flow profile over the course of a month following Pan-Retinal Photocoagulation (PRP). Materials and Methods: A total of Thirteen individuals in the earliest stages of Proliferative Diabetic Retinopathy (PDR) were included in this follow-up investigation. This study has excluded patients who have had prior therapy for Diabetic Retinopathy (DR) or any other retinal disease. Before and after PRP treatment, all participants had a comprehensive eye exam and had a macular optical coherence tomography angiography (AngioVue RTVue XR Avanti, Optovue, Fremont, CA, USA, software version: 2018,0,0,18) performed using a 6-by-6-millimeter scan size. Superficial and deep capillary plexus were analyzed. Results: 13 patients, 6 male (46%) and 7 female (54%), with PDR, participated in this study. The mean± Sd of the patient’s age was 55.25±9.28 years. Foveal Avascular Zone (FAZ), Deep Vessel Density (DVD), macular Superficial Vessel Density (SVD), and area alterations in PDR patients before and after PRP were not statistically significant, according to this study. Conclusion: Although a reduction in SFVD, DFVD, and FAZ area in the 1st month following PRP was shown. PRP in patients with early PDR stage of diabetic retinopathy did not have a significant effect on the macular vasculature during the first month of treatment. https://fbt.tums.ac.ir/index.php/fbt/article/view/768 https://fbt.tums.ac.ir/index.php/fbt/article/download/768/492