Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 0 0 2024 05 10 842 842 Hanie Arabian Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran Alireza Karimian Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran Hamid Reza Marateb Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran. Department of Automatic Control, Biomedical Engineering Research Center, Polytechnic University of Catalonia, BarcelonaTech (UPC), Barcelona, Spain. 2023 10 08 2023 12 02 Abstract Purpose: Magnetoencephalography is the recording of magnetic fields resulting from the activities of brain neurons and provides the possibility of direct measurement of their activity in a non-invasive manner. Despite its high spatial and temporal resolution, magnetoencephalography has a weak amplitude signal, drastically reducing the signal-to-noise ratio in case of environmental noise. Therefore, signal reconstruction methods can be effective in recovering noisy and lost information. Materials and Methods: The magnetoencephalography signal of 11 healthy young subjects was recorded in a resting state. Each signal contains the data of 148 channels which were fixed on a helmet. The performance of three different reconstruction methods has been investigated by using the data of adjacent channels from the selected track to interpolate its information. These three methods are the surface reconstruction methods, partial differential equations algorithms, and finite element-based methods. Afterward to evaluate the performance of each method, R-square, root mean square error, and signal-to-noise ratio between the reconstructed signal and the original signal were calculated. The relation between these criteria was checked through proper statistical tests with a significance level of 0.05. Results: The mean method with the root mean square error of 0.016  0.009 (mean  SD) at the minimum time (3.5 microseconds) could reconstruct an epoch. Also, the median method with a similar error but in 5.9 microseconds with a probability of 99.33% could reconstruct an epoch with an R-square greater than 0.7. Conclusion: The mean and median methods can reconstruct the noisy or lost signal in magnetoencephalography with a suitable percentage of similarity to the reference by using the signal of adjacent channels from the damaged sensor. https://fbt.tums.ac.ir/index.php/fbt/article/view/842 https://fbt.tums.ac.ir/index.php/fbt/article/download/842/408