Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 0 0 2025 03 04 979 979 Kumar Prasun PadmaKanya Multiple Campus Santosh Kumar Sharma Nepal College of Information Technology, Kathmandu, Nepal 2024 03 23 2025 02 24 Purpose: One of the increasing neurological disorders is Alzheimer's, which progressively weakens brain cells and leads to critical cerebral impairments like memory loss. The present diagnostic techniques comprise PET scans, MRI scans, CSF biomarkers, and others that frequently need manual power and time-consuming process which might not offer appropriate results. This emphasizes the requirement for more precise and potential diagnostic solutions. Materials and Methods: The proposed model utilizes AI-based Deep Learning (DL) techniques for effective multi-class classification of AD such as Early Mild Cognitive Impairment (EMCI), Late Mild Cognitive Impairment (LMCI), Mild Cognitive Impairment (MCI), Cognitive Normal (CN) and Alzheimer’s Disease (AD) using Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. The proposed study utilizes Tri Branch Attention Network (TBAN) with Unified Component Incorporation (UCI) by capturing both spatial and channel attention information, by replacing the Squeeze and Excitation (SE) component in the conventional EfficientNet model and helps in addressing the concerns associated to imbalanced spatial feature distribution in images. Further, the incorporation of the proposed TBAN module in the Conv Layer helps, not only in terms of capturing the long-term dependence between the different channels of the network but also helps in retaining the specific location information to enhance the performance of the model. Similarly, the proposed UCI which is used in the MBConv layer deals with regularization, as the accuracy of the model can be dropped due to unbalanced regularization, hence the incorporation of UCI advocates strong regularization for combatting the concerns associated with overfitting and aids in providing better accuracy. Results: Eventually, the proposed framework is evaluated with different metrics and the accuracy value obtained by the proposed model is 0.95. Likewise, precision, recall, and F1 scores gained by the proposed work are 0.95, 0.95, and 0.95. Conclusion: The proposed research resolves significant gaps in the present diagnostic practices by implementing emerged AI techniques to improve the efficacy and accuracy of Alzheimer's diagnosis by medical imaging. Through enhancing the abilities of early detection, this proposed model holds the prospective to majorly affect treatment tactics for people affected with Alzheimer's. Finally, it led to better patient consequences and life quality. https://fbt.tums.ac.ir/index.php/fbt/article/view/979 https://fbt.tums.ac.ir/index.php/fbt/article/download/979/495