Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 1 4 2014 12 30 233 239 EN Samaneh Kouchaki Kouchaki Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, UK. Konstantinos Eftaxias Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, UK. Saeid Sanei Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, UK. 2015 10 13 2015 10 13 Purpose: Sleep is a complex physiological state and an indicator of the changes in the brain function similar to those occurring in many psychiatric and neurological conditions. Since visual sleep scoring consuming process, automatic sleep staging methods, also called scoring, hold promise in diagnosing alterations in the sleep process and the sleep EEG more effectively. Method: In this paper, a supervised approach for sleep scoring from single channel EEG signals is proposed. First, a supervised singular spectrum analysis (SSA) which is a subspace based method is used to extract the desired signal for each stage of sleep. Then, two recursive least squares (RLS) adaptive filters are trained and used to identify first and deep sleep stages. Result: The proposed system which can be considered as a filter bank for separating multiple signal subbands is tested using real EEG where the results verify the accuracy of the proposed method. Conclusion: The overall result show the effectiveness of algorithm for detection of sleep stages from EEG signals often characterised by a sharp increase in delta and a rapid decrease in alpha as sleep deepens. https://fbt.tums.ac.ir/index.php/fbt/article/view/15 https://fbt.tums.ac.ir/index.php/fbt/article/download/15/14

Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 1 4 2014 12 30 240 251 EN Rezvan Ravanfar-Haghighi Medical Imaging Research Center, Radiology Department, (b) Colorectal Research Center.Namazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Sabyasachi Chatterjee BGVS, Chemical Engineering Building (Old), Indian Institute of Science, Bangalore 560 012. India. Pratik Kumar Medical Physics Unit, Dr B.R. Ambedkar IRCH, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India. Vani Varadhan Chatterjee Department of Instrumentation and Applied Physics, Indian Institute of Science, Bangalore 560012, India. 2015 10 13 2015 10 13 Purpose: Attenuation of x-rays in any object is a combined effect of scattering and absorption of x-ray photons by the atoms in the material. While the scattering part dependents linearly upon the material’s electron density (ρe) and is weakly dependent on the energy (E) of the photon, the photoelectric part varies as [ρe Zx eff /Ey] where Zeff is the effective atomic number of the material. We aim to determine the exponents (x,y) which are crucial for many radiological studies. Methods: In order to obtain exponent ‘y’, we find an equation in which the exponent x does not appear and the dependence on ‘y’ appears only linearly. Having thus reduced the problem to that of ‘one parameter fit’ in ‘y’, we generate the ‘data’ numerically from the numerical values of physical constants given in the NIST (The National Institute of Standards and Technology, or NIST) tables and determine ‘y’ from linear regression. The effect of the source spectrum on the effective value of ‘y’, denoted by ‘ym’ is studied for different low Zeff substances in different energy ranges. Results: It is seen that with x-ray sources operating at 80, 100,120,140 kVp, the effective exponent ‘y’ progressively decreases, as the x-ray source spectrum is pushed to higher energy side. However, for most practical purposes y=2.99 may be used for a wide variety of low Zeff substances. For practical cases with different source spectra, the effective energy of the source and the effective photoelectric exponent are seen to increase as the thickness of the aluminum filter increases. Conclusion: It thus follows that for applications such as DECT inversion, the appropriate values of ‘ym’ ought to be used that takes into account the appropriate source spectrum. https://fbt.tums.ac.ir/index.php/fbt/article/view/19 https://fbt.tums.ac.ir/index.php/fbt/article/download/19/18

Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 1 4 2014 12 30 252 257 EN Pardis Ghafarian Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid BeheshtiUniversity of Medical Sciences, Tehran, Iran AND PET/CT and Cyclotron Center of Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad Reza Ay Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran AND Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 13 2015 10 13 Purpose: Potential causes of misalignment between anatomical and functional images in cardiac PET/CT imaging include respiratory and cardiac motion as well as bulk motion. In this study we evaluated the impact of respiratory and cardiac motion between CT and corresponding CT-based attenuation corrected (CTAC) PET images on apparent myocardial uptake. Methods: PET projection data of the 4D XCAT phantom were analytically generated using an analytic simulator considering the effect of photon attenuation and Poisson noise. The assessment of PET images was performed through qualitative interpretation by an experienced nuclear medicine physician and a volume of interest based quantitative analysis. Moreover, Box and Whisker plots were calculated and bull’s eye view analysis performed. PET images were also reoriented along the short, horizontal and vertical long axis views for a better qualitative interpretation. Results: The simulation study showed that using the attenuation map at end-exhalation of the respiratory phase consistently overestimated the activity concentration in all segments of the myocardial wall as opposed to using the end-inhalation attenuation map image which resulted in underestimation Conclusion: CT images acquired at end-exhalation could introduce larger errors compared to end-inhalation. These errors decrease significantly when the attenuation map was acquired at mid-inhalation or mid-exhalation phases of the respiratory cycle. https://fbt.tums.ac.ir/index.php/fbt/article/view/21 https://fbt.tums.ac.ir/index.php/fbt/article/download/21/20

Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 1 4 2014 12 30 258 264 EN Tahereh Jafarzadeh-Kashi Department of Dental Biomaterials, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Maryam Hajihasani Department of Dental Biomaterials, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Soolmaz Heidari Department of Dental Biomaterials, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Kimia Khoshroo Department of Dental Biomaterials, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Reza Masaeli Department of Dental Biomaterials, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Mohammadreza Tahriri Department of Dental Biomaterials, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran AND Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran. 2015 10 13 2015 10 13 Purpose: The properties of resin-based composites as polymeric materials are related to the quality of polymerization. Microhardness measurement is an indirect method to predict this quality. Irradiation time and distance as factors related to light-curing process play important roles in this issue. The purpose of this study was to evaluate the effect of irradiation time and distance on the microhardness values of three different commercial nanohybrid resin-based composites. Methods: A total of 180 disk-shaped specimens (60 specimens for each commercial resinbased composite) from three nanohybrid resin-based composites [Grandio (Voco), Simile (Pentron) and Tetric N- Ceram (Ivoclar Vivadent)] in A2 shade were prepared. The specimens were randomly subdivided in 6 subgroups (3 subgroups for evaluating irradiation time: 10 s, 20 s and 40 s, 3 subgroups for irradiation distance: 0 mm, 3 mm and 9 mm) which 10 specimens from each commercial resin-base composite were used for each subgroup. Vickers microhardness test was performed for the top and bottom surfaces of each sample using a microhardness tester under a 200 gr load and a dwell time of 15 s. Three random indentations were taken for each surface and a mean value was calculated. Data were analyzed by two and three way ANOVA and Tukey’s post-hoc test at the 95% significance level. Results: The microhardness values showed significant differences between subgroups for different irradiation times and distances (p value ≤ 0.001).).The only exception was Simile group which there was no significant difference for microhardness values between 0 and 3 mm distances. Grandio showed the highest microhardness values among others. Conclusion: Increasing the irradiation time and decreasing the irradiation distance caused an increase in microhardness values. Also, the microhardness of the resin-based composites was affected by the chemical structure of the material. https://fbt.tums.ac.ir/index.php/fbt/article/view/22 https://fbt.tums.ac.ir/index.php/fbt/article/download/22/21

Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 1 4 2014 12 30 265 270 EN Hojjat Mahani Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran AND Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran. Alireza Kamali-Asl Radiation Medicine Engineering Department, Shahid Beheshti University, Tehran, Iran. Mohammad Reza Ay Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran AND Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 13 2015 10 13 Purpose: Mechanical calibration of camera plays an important role in nuclear imaging to acquire a more qualified and quantized scintigram. The objective of this work was to quantitatively evaluate planar resolution and sensitivity of a tilted Anger camera using a Monte Carlo simulation. Methods: For this purpose, spatial resolution and system sensitivity of a tilted-head, LEHR collimated gamma-camera were evaluated using Monte Carlo simulation. To do so, tilt-angle of camera’s head was considered to vary from -10 to 10 degrees from the baseline. The Monte Carlo simulated data were validated by means of a comparison with experimental data. In addition, the performance of the system was analyzed both in spatial and frequency domains. Results: Spatial resolution, in terms of FWHM, for simulated and measured point-spread functions (PSFs), at the rest-position has a value of 7.22 mm and 7.43 mm, respectively. The results also show that the spatial resolution monotonically increases as the absolute value of tilt angles increases, up to a degradation factor of 2.02 for a typical scintillation-camera. System sensitivity exhibits a constant behavior for all tilt-angles with a maximum statistical fluctuation of 2%. Conclusion: While a head tilt has no effect on the sensitivity of the camera, it can result in a poor and spatially variable planar spatial resolution and contrast of the images provided by the tilted-scanner. https://fbt.tums.ac.ir/index.php/fbt/article/view/24 https://fbt.tums.ac.ir/index.php/fbt/article/download/24/23

Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 1 4 2014 12 30 271 278 EN Azadeh Emami Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran AND Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran. Hossein Ghadiri Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran AND Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran. Pardis Ghafarian Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran AND PET/CT and cyclotron Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2015 10 13 2015 10 13 Purpose: Accurate performance assessment of bone mineral density (BMD) methods is crucial due to the fact that a high level of exact estimation of bone situation is needed for correct diagnosis. Variation of parameters like sensitivity and error ratio highly affects the densitometry results that may induce some level of uncertainty in diagnosis. So, designing an algorithm for correction is necessary to assure examiners about measurement results. Methods: In this study several phantoms consisting of soft tissue- and bone-equivalent materials were devised to accurately test bone densitometry systems. To the best of our knowledge there is no unique phantom to be able to use for evaluation of both Dual Energy X-ray Absorptiometry (DEXA) and Quantitative Computed Tomography (QCT) in a wide range of density. The main motivation of this study was to design a reliable and easy to use phantom. A QCT quality control, quality assurance, and Plexiglas cylindrical phantoms as a spine phantom were designed and constructed to assess different bone densities. Four inserts in spine phantom with precisely wide range of K2HPO4 solutions were used for simulation of bone tissues and to determine the BMD systems characteristics. The designed phantoms were also used for performance assessment of BMD systems. We used a sinogram-based analytical CT simulator to model the complete chain of CT data acquisition for QCT method as well. Results: In this research it is demonstrated that by decreasing of bone mineral densities an increasing trend in error ratio of measured densities and declining trend in methods sensitivities were observed in the both DEXA and QCT methods, that may cause some level of uncertainty in low densities. It has been shown that between the ranges of 20 and 100 mg/cc K2HPO4 concentrations, the error ratio in both DEXA and QCT techniques is more than 20%. Sensitivity values in incremental mineral contents ranges between 20- 60 mg/cm 3 and 260-300 mg/cm 3 reveal an upward trend between 0.93 and 1.45 for QCT and from 0.59 to 1.44 for DEXA, respectively. Conclusion: A novel phantom was designed with capability of easily supporting wide range of densities and using in both DEXA and QCT techniques to measure and compare the sensitivity and error of systems. Our phantom showed excellent capability for accurate determination of BMD, particularly in low density bones. In this study it is demonstrated that the sensitivity and error ratio is affected by bone density that may cause uncertain results especially in low densities. https://fbt.tums.ac.ir/index.php/fbt/article/view/26 https://fbt.tums.ac.ir/index.php/fbt/article/download/26/25

Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 1 4 2014 12 30 279 283 EN Mohammad Keshtkar Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran AND Department of Medical Physics, Isfahan University of Medical Sciences, Isfahan, Iran. Abbas Takavar Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Hassan Zahmatkesh University of Shahid Beheshti, Faculty of Nuclear engineering, Department of Medical Physics. Ali Vaezzadeh Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran. Mehrdad Gholami Department of Medical Physics, Lorestan University of Medical Sciences, Khorram Abad, Iran. Zeinab Ghasemian Department of Medical Physics, Isfahan University of Medical Sciences, Isfahan, Iran. 2015 10 13 2015 10 13 Purpose: Dosimetry is an integral part of radiotherapy and dose verification is one of the important stages in modern radiotherapy. Nowadays gel dosimeters are the only dosimeters that can record dose distribution in three dimensions only with a single measurement. The purpose of this study was to evaluate the capability of polymer gel dosimetry in dose verification of compensator-based IMRT. Methods: A cerrobend slab with 4 cm thickness was manufactured and percentage depth dose curves for 18 MV photon beam and 10×10 cm2 field size were obtained by ionization chamber and polymer gel dosimeter. Then, an anthropomorphic pelvic phantom with gel inserts was constructed and irradiated with compensator-based IMRT technique. Results: A comparison of the result of dose measurements with ion chamber and gel dosimeter showed that in spite of changing mean beam quality, compensators have no effect on response of gel dosimeter. Besides, according to distance to agreement (DTA) analysis there was good agreement between calculated and gel measured dose distributions. Conclusion: The methodology presented in this work proved the feasibility of polymer gel dosimeter as an ideal tool for pretreatment IMRT QA and also the constructed phantom can be used efficiently in other radiotherapy techniques. Future works will be focused on the development of lung equivalent polymer gel dosimeter. https://fbt.tums.ac.ir/index.php/fbt/article/view/28 https://fbt.tums.ac.ir/index.php/fbt/article/download/28/27

Tehran University of Medical Sciences Frontiers in Biomedical Technologies 2345-5837 1 4 2014 12 30 284 291 EN Javad Hasani-Bidgoli Research Center of Biomedical Technology ad Robotics (RCBTR), Tehran University of Medical Sciences, Iran AND School of Electrical & Computer Engineering, Collage of Engineering, University of Tehran, Tehran, Iran. Seyed Mousa Sadr Hosseini Department of ENT, Vali Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran. Ali Safavi-Naeini Department of ENT, NRITLD, Shaheed Beheshti Medical Sciences University, Tehran, Iran. Hooshang Saberi Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran AND Brain and Spinal Injuries Repair Research Center (BASIR), Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Jalal Sadeghi Research Center of Biomedical Technology ad Robotics (RCBTR), Tehran University of Medical Sciences, Iran. Saeed Karimi-Fard Research Center of Biomedical Technology ad Robotics (RCBTR), Tehran University of Medical Sciences, Iran. Habib Salimi Research Center of Biomedical Technology ad Robotics (RCBTR), Tehran University of Medical Sciences, Iran. Alireza Ahmadian Research Center of Biomedical Technology ad Robotics (RCBTR), Tehran University of Medical Sciences, Iran AND Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran. Farzam Farahmand Research Center of Biomedical Technology ad Robotics (RCBTR), Tehran University of Medical Sciences, Iran. Saeed Sarkar Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 13 2015 10 13 Purpose: In this report, a thorough validation of PARSISS Image Guided Surgery has beenpresented. Methods: Different experiments have been designed to evaluate Parsiss navigation system under three main scopes: first, a phantom study using a sophisticated precise phantom with 732 landmarks was constructed by 3d printing with layers of 16 micron thickness and 0.1 mm precision; second, performing preclinical cadaver experiment with titanium placed markers; and third, clinical evaluation which was carried out on 957 cases from 2010 to 2014. Results: Results obtained from three evaluation methods showed that the system was foundreliable and usable. Briefly, the average registration error in PARSISS precise phantom test was reported lower than 2 mm this which is clinically acceptable and reasonable in neurosurgery and ENT surgeries. In clinical evaluation, surgeons approved the accuracy and reliability of the system in thorough clinical evaluation in 94% of cases of 957 patients. Conclusion: In this study, the results of all three approaches were positive and reliable. Especially, evaluations using a large number of patients showed that the PARSISS surgical navigation system has shown high level of reliability in clinical procedures. https://fbt.tums.ac.ir/index.php/fbt/article/view/17 https://fbt.tums.ac.ir/index.php/fbt/article/download/17/16