Cadmium Oxide Nanoparticles Synthesis Using Pulsed Laser Ablation in a Liquid Medium and Investigation of their Antibacterial Activity
Abstract
Purpose: Recent years have witnessed a significant amount of research into laser ablation in liquids due to the many potential applications of laser microprocessing of materials, including the synthesis of nanomaterials and nanostructures. This study aims to explore the antibacterial effects of cadmium oxide on both positive and negative bacteria.
Materials and Methods: Pulsed Laser Ablation (PLA) in liquid is a straightforward and environmentally friendly technical technique that works in water or other organic liquids under ambient conditions, in contrast to other, usually chemical methods. Here, 30 milliliters of deionized water were used to create Cadmium Oxide (CdO) nanoparticles using the PLA method. UV-vis spectrometry, FT-IR, X-ray spectroscopy, and FESEM were utilized to analyze the products' morphology, spectral content, and particle size.
Results: The produced nanocomposites were tested as antibacterial agents against gram-negative bacteria (Proteus mirabilis and Escherichia coli) as well as gram-positive bacteria (Staphylococcus aureus and Enterococcus faecalis). The MIC results on the MTP plate with the synthesized Cd NPS compound were as follows: Proteus mirabilis (6.25%), Escherichia coli (12.5%), Enterococcus faecalis (12.5%), and Staphylococcus aureus (12.5%). These findings indicate that the synthesized nanoparticles exhibit comparable antibacterial activity against both Gram-positive and Gram-negative bacteria.
Conclusion: The synthesized nanoparticles made of CdO demonstrated notable antibacterial activity that was effective against all of the bacteria that were tested in the experiments. This indicates that the CdO nanocomposite has the potential to inhibit the growth of a wide variety of bacterial strains.
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34- Mohamed Elshikh et al., "Resazurin-based 96-well plate microdilution method for the determination of minimum inhibitory concentration of biosurfactants." Biotechnology Letters, Vol. 38, pp. 1015-19, (2016).
35- EF El Agammy, MF Hasaneen, Amr A Essawy, Shaima MN Moustafa, GE Khalil, and AM Nassar, "Effect of Nd: YAG pulsed laser on the antibacterial activity and physical properties of newly synthesized composites, CdO/Co3O4 and Ag/CdO/Co3O4." Physica Scripta, Vol. 99 (No. 1), p. 015903, (2023).
2- Vaishali N Sonkusare, Ratiram Gomaji Chaudhary, Ganesh S Bhusari, Alok R Rai, and Harjeet D Juneja, "Microwave-mediated synthesis, photocatalytic degradation and antibacterial activity of α-Bi2O3 microflowers/novel γ-Bi2O3 microspindles." Nano-Structures & Nano-Objects, Vol. 13, pp. 121-31, (2018).
3- Seraj Mohaghegh, Ali Tarighatnia, Yadollah Omidi, Jaleh Barar, Ayuob Aghanejad, and Khosro Adibkia, "Multifunctional magnetic nanoparticles for MRI-guided co-delivery of erlotinib and L-asparaginase to ovarian cancer." Journal of Microencapsulation, Vol. 39 (No. 4), pp. 394-408, (2022).
4- Shiza Malik, Khalid Muhammad, and Yasir Waheed, "Emerging applications of nanotechnology in healthcare and medicine." Molecules, Vol. 28 (No. 18), p. 6624, (2023).
5- Peyman Ghoranneviss, Davoud Dorranian, and Amir Hossein Sari, "Effects of laser fluence on the Cd (OH) 2/CdO nanostructures produced by pulsed laser ablation method." Optical and Quantum Electronics, Vol. 51 (No. 3), p. 88, (2019).
6- NB Sonawane, PK Baviskar, RR Ahire, and BR Sankapal, "CdO necklace like nanobeads decorated with PbS nanoparticles: room temperature LPG sensor." Materials Chemistry and Physics, Vol. 191, pp. 168-72, (2017).
7- Savita Patil, Shrikant Raut, Ratnakar Gore, and Babasaheb Sankapal, "One-dimensional cadmium hydroxide nanowires towards electrochemical supercapacitor." New Journal of Chemistry, Vol. 39 (No. 12), pp. 9124-31, (2015).
8- Ameer Azam, Arham S Ahmed, Mohammad Oves, Mohammad S Khan, Sami S Habib, and Adnan Memic, "Antimicrobial activity of metal oxide nanoparticles against Gram-positive and Gram-negative bacteria: a comparative study." International Journal of Nanomedicine, pp. 6003-09, (2012).
9- ABEER A Abass, MA Wasna’a, and ZUHAIR S Alsehlawi, "Characterization Of Antimicrobial Activity Of Gold Nanoparticlesprepared By Pulse Laser Ablation In Liquid." Asian Jr of Microbiol Biotech Env Sc, Vol. 21 (No. 1), p. 2, (2019).
10- Alessia Catalano et al., "Multidrug resistance (MDR): A widespread phenomenon in pharmacological therapies." Molecules, Vol. 27 (No. 3), p. 616, (2022).
11- Megan Bergkessel, Barbara Forte, and Ian H Gilbert, "Small-molecule antibiotic drug development: need and challenges." ACS Infectious Diseases, Vol. 9 (No. 11), pp. 2062-71, (2023).
12- Ali H Attallah, Farah Shamil Abdulwahid, Yasir A Ali, and Adawiya J Haider, "Effect of liquid and laser parameters on fabrication of nanoparticles via pulsed laser ablation in liquid with their applications: a review." Plasmonics, Vol. 18 (No. 4), pp. 1307-23, (2023).
13- Regina Huang et al., "Nano-based theranostic approaches for the infection control: current states and perspectives." Materials Chemistry Frontiers, (2024).
14- Ashley N Brown, Kathryn Smith, Tova A Samuels, Jiangrui Lu, Sherine O Obare, and Maria E Scott, "Nanoparticles functionalized with ampicillin destroy multiple-antibiotic-resistant isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and methicillin-resistant Staphylococcus aureus." Applied and Environmental Microbiology, Vol. 78 (No. 8), pp. 2768-74, (2012).
15- Molly Kukua Abban, Eunice Ampadubea Ayerakwa, Lydia Mosi, and Abiola Isawumi, "The burden of hospital acquired infections and antimicrobial resistance." Heliyon, (2023).
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18- Hans Ram Meena and Vikash Kumar, "Antimicrobial resistance and rational use of antimicrobials in livestock: developing countries’ perspective." Livestock Health and Farming, p. 11, (2019).
19- Helal F Hetta et al., "Nanotechnology as a promising approach to combat multidrug resistant bacteria: a comprehensive review and future perspectives." Biomedicines, Vol. 11 (No. 2), p. 413, (2023).
20- Wei Zou, Alyssa McAdorey, Hongbin Yan, and Wangxue Chen, "Nanomedicine to overcome antimicrobial resistance: Challenges and prospects." Nanomedicine, Vol. 18 (No. 5), pp. 471-84, (2023).
21- AM Ismail, Rania Ramadan, and Mai M El-Masry, "The role of nanoparticles inclusion in monitoring the physical properties of PVDF." Journal of the Australian Ceramic Society, Vol. 59 (No. 2), pp. 333-41, (2023).
22- Mohammad Tabish, Mohd Moonis Zaheer, and Abdul Baqi, "Effect of nano-silica on mechanical, microstructural and durability properties of cement-based materials: A review." Journal of Building Engineering, Vol. 65, p. 105676, (2023).
23- Alireza Ghasempour et al., "Cadmium sulfide nanoparticles: preparation, characterization, and biomedical applications." Molecules, Vol. 28 (No. 9), p. 3857, (2023).
24- J Christina Rhoda, S Chellammal, Helen Merina Albert, K Ravichandran, and C Alosious Gonsago, "Synthesis, Spectroscopic, and antibacterial characterizations of cadmium–based nanoparticles." Journal of Fluorescence, Vol. 34 (No. 2), pp. 587-98, (2024).
25- Ikechukwu P Ejidike et al., "Cadmium oxide nanoparticles from new organometallic Cd (II)-Schiff base complex and in vitro biological potentials: dual S. aureus and E. coli DNA gyrase inhibition by the precursors via in silico binding modes’ study." Research on Chemical Intermediates, Vol. 50 (No. 6), pp. 2763-91, (2024).
26- Khanderao Pagar et al., "Bio-inspired synthesis of CdO nanoparticles using Citrus limetta peel extract and their diverse biomedical applications." Journal of Drug Delivery Science and Technology, Vol. 82, p. 104373, (2023).
27- MA Gondal, Tawfik A Saleh, and QA Drmosh, "Synthesis of nickel oxide nanoparticles using pulsed laser ablation in liquids and their optical characterization." Applied Surface Science, Vol. 258 (No. 18), pp. 6982-86, (2012).
28- Eman A Mwafy, Mohamed S Hasanin, and Ayman M Mostafa, "Cadmium oxide/TEMPO-oxidized cellulose nanocomposites produced by pulsed laser ablation in liquid environment: synthesis, characterization, and antimicrobial activity." Optics & Laser Technology, Vol. 120, p. 105744, (2019).
29- D DurgaVijaykarthik, M Kirithika, N Prithivikumaran, and N Jeyakumaran, "Synthesis and characterization of Cadmium Oxide nanoparticles for antimicrobial activity." (2014).
30- M Tabatabaee, AA Mozafari, M Ghassemzadeh, M Reza Nateghi, and I Abedini, "A simple method for synthesis of cadmium oxide nanoparticles using polyethylene glycol." Bulg. Chem. Comm, Vol. 45, pp. 90-92, (2013).
31- Ahmed N Abd, Mohammed F Al-Marjani, and Zahraa A Kadham, "Antibacterial activity of cadmium oxide nanoparticles synthesized by chemical method." Journal of Multidisciplinary Engineering Science and Technology, Vol. 3 (No. 6), pp. 5007-11, (2016).
32- Lucien Barnes, Douglas M Heithoff, Scott P Mahan, John K House, and Michael J Mahan, "Antimicrobial susceptibility testing to evaluate minimum inhibitory concentration values of clinically relevant antibiotics." STAR Protocols, Vol. 4 (No. 3), p. 102512, (2023).
33- Faraja D Gonelimali et al., "Antimicrobial properties and mechanism of action of some plant extracts against food pathogens and spoilage microorganisms." Frontiers in Microbiology, Vol. 9p. 1639, (2018).
34- Mohamed Elshikh et al., "Resazurin-based 96-well plate microdilution method for the determination of minimum inhibitory concentration of biosurfactants." Biotechnology Letters, Vol. 38, pp. 1015-19, (2016).
35- EF El Agammy, MF Hasaneen, Amr A Essawy, Shaima MN Moustafa, GE Khalil, and AM Nassar, "Effect of Nd: YAG pulsed laser on the antibacterial activity and physical properties of newly synthesized composites, CdO/Co3O4 and Ag/CdO/Co3O4." Physica Scripta, Vol. 99 (No. 1), p. 015903, (2023).
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How to Cite
1.
Shukur RH, Hasan SM. Cadmium Oxide Nanoparticles Synthesis Using Pulsed Laser Ablation in a Liquid Medium and Investigation of their Antibacterial Activity. Frontiers Biomed Technol. 2024;.
