Original Article

Improving Early Detection and Diagnosis of Lung Cancer using Enhanced Ensemble Deep Learning Model on CT images

Abstract

Purpose: Lung cancer is the most common and deadliest type of cancer that is the cause of one million deaths around the world every year. Due to the present level of medical research, identifying lung tumors on chest Computed Tomography (CT) images has become a significant process in modern medicine. Enhancing treatment and reducing lung cancer mortality can be achieved by promptly identifying and accurately diagnosing suspected malignant lung tumors. While many deep learning algorithms have been developed recently for the classification of lung cancer, achieving high accuracy in lung cancer classification is still a challenge. An advanced deep learning technique is designed to boost the effectiveness of early lung cancer diagnosis.

Materials and Methods: In this research, we have proposed an enhanced ensemble deep-learning model for lung cancer classification and segmentation. Initially, we carried out an extensive pre-processing process, including image resizing, noise reduction, and contrast enhancement, to enhance the image quality. The problem of small sample size is addressed by applying conventional data augmentation techniques like flipping, rotating, zooming, and shearing. Next, seven statistical features are retrieved using Improved Empirical Wavelet Transforms (IEWT). After feature extraction, the Enhanced ResNeXt model is used to classify lung cancer into normal, malignant, and benign classes. The interested region of the lung tumor is segmented using the Modified ShuffleNetV2 model. Individuals are classified into normal, malignant, and benign categories based on the presence of lung cancer. The experiments are performed on the benchmark datasets LIDC-IDRI and IQ-OTH/NCCD.

Results: For lung cancer classification, the proposed Enhanced ResNeXt model achieves an exceptional model accuracy of 99.43% for the IQ-OTH/NCCD dataset and 99.37% for the LIDC-IDRI dataset. Furthermore, the proposed Modified ShuffleNetV2 model effectively segments lung tumor regions, achieving an Intersection over Union (IOU) of 98.43% and a Dice Similarity Coefficient (DSC) of 97.24% on the LIDC-IDRI dataset, and an IOU of 97.05% and DSC of 96.23% on the IQ-OTH/NCCD dataset, demonstrating its robustness and accuracy in delineating tumor boundaries. The expected outcomes show that the accuracy and efficiency of our proposed ensemble deep learning model outperform other CNNs.

Conclusion: The proposed models beat existing CNN-based models in terms of speed and number of training parameters, which means that using CT scan images to diagnose lung cancer automatically is a suitable option and a strong selection for extensive use in medical environments.

1- C. S. Parvathy and J. P. Jayan, "Automatic Lung Cancer Detection Using Computed Tomography Based on Chan Vese Segmentation and SENET", Optical Memory and Neural Networks, vol. 33(3), pp.339-354, (2024).
2- M. Coumarane, M. Balasubramanian and S. Sathiya," Deep Learning Techniques for Discerning Various Phases in Lung Cancer Disease using Chest X-Ray Images", Journal of Electrical Systems, vol. 20(3), pp.2826-2834, (2024).
3- R. Paramasivam, S. N.Patil, S. Konda and K. L.Hemalatha, "Lung cancer computed tomography image classification using Attention-based Capsule Network with dispersed dynamic routing", Expert Systems, vol. 41(9), p.e13607, (2024).
4- A. Feroui, M. Saim, M. E. A. Lazouni, S. A. Lazzouni, Z. A. Elaouaber and M. Messadi, "Improved diagnosis of lung cancer classification based on deep learning method", International Journal of Biomedical Engineering and Technology, vol. 46(2), pp.138-159, (2024).
5- S. Jain and P. Jaidka, "Lung Cancer Classification Using Deep Learning Hybrid Model", In Future of AI in Medical Imaging pp. 207-223, (2024) IGI Global.
6- X. Cheng, J. Li, M. Mi, H. Wang, J. Wang and P. Su, "Accuracy Study on Deep Learning-Based CT Image Analysis for Lung Nodule Detection and Classification", Traitement du Signal, vol. 41(2), (2024).
7- L. K.Gaddala, V. K. Reddy Radha, S. R.Buraga, V. L.Narla, K. R. Kodepogu and S. Yalamanchili, "Machine Learning-Based Lung Cancer Classification and Enhanced Accuracy on CT Images", Traitement du Signal, vol. 41(2), (2024).
8- T. Lan, F. Zeng, Z. Yi, X. Xu, and M. Zhu, "ICNoduleNet: Enhancing Pulmonary Nodule Detection Performance on Sharp Kernel CT Imaging", IEEE Journal of Biomedical and Health Informatics, (2024).
9- B. Mostafa, A. Keshk and M. Sakr, "A Deep-Learning Model Based on Transfer-Learning Technique for Detecting and Classifying Anomalies in Lungs Images", IJCI. International Journal of Computers and Information, vol. 10(3), pp.63-72, (2023).
10- D. Wang, C. Han, Z. Zhang, T. Zhai, H. Lin, B. Yang, Y. Cui, Y. Lin, Z. Zhao, L. Zhao and C. "Liang, FedDUS: Lung tumor segmentation on CT images through federated semi-supervised with dynamic update strategy", Computer Methods and Programs in Biomedicine, vol. 249, p.108141, (2024).
11- J. Subash and S. Kalaivani, "Dual-stage classification for lung cancer detection and staging using hybrid deep learning techniques", Neural Computing and Applications, vol. 36(14), pp.8141-8161, (2024).
12- V. Gampala, V. Ramya, B. Maram and S. R.Pappu, "Identification of lung cancer using archimedes flow regime optimization enabled deep belief network", Multimedia Tools and Applications, pp.1-30, (2024).
13- M. Jha, R. Gupta and R. Saxena, "Convolutional neural network based detection of lung adenocarcinoma by amalgamating hybrid features", International Journal of Advanced Technology and Engineering Exploration, vol. 11(111), p.160, (2024).
14- Z. Gao, Y. Guo, G. Wang, X. Chen, X. Cao, C. Zhang, S. An and F. Xu, "Robust deep learning from incomplete annotation for accurate lung nodule detection", Computers in Biology and Medicine, vol. 173, p.108361, (2024).
15- C. S. Parvathy and J. P.Jayan, "Lung cancer prediction in chest CT using an active contour-based segmentation and 3DCNN", Multimedia Tools and Applications, vol. 83(21), pp.60493-60517, (2024).
16- P. Ramasamy, E. Alabdulkreem, N. Alruwais and V. P.Gladis Pushparathi, "An attention-based neural network for lung cancer classification and gradient in MRI", Automatika, vol. 65(4), pp.1379-1390, (2024).
17- A. Hassan, H. Khan, A. Ali, A. Sajid, M. Husain, M. Ali, A. Naz and H. Fakhar, "An Enhanced Lung Cancer Identification and Classification Based on Advanced Deep Learning and Convolutional Neural Network", Bulletin of Business and Economics (BBE), vol. 13(2), pp.136-141, (2024).
18- S. A. Agnes, A. A. Solomon, and K. Karthick, "Wavelet U-Net++ for accurate lung nodule segmentation in CT scans: Improving early detection and diagnosis of lung cancer", Biomedical Signal Processing and Control, vol. 87, p.105509, (2024).
19- K. Priyadarshini, M. Alagarsamy, K. Sangeetha and D. Thangaraju, "Hybrid RNN-FFBPNN Optimized with Glowworm Swarm Algorithm for Lung Cancer Prediction", IETE Journal of Research, vol.70(5), pp.4453-4468, (2024).
20- P. Saravanaprasad and S.A. Karuppusamy, "Advanced lung tumor diagnosis using a 3D deep neural network based CAD system", Biomedical Signal Processing and Control, vol.89, p.105650, (2024).
21- A. Gupta, A. Kumar and K. Rautela, "UDCT: lung Cancer detection and classification using U-net and DARTS for medical CT images", Multimedia Tools and Applications, pp.1-21, (2024).
22- S. Mahesh, "Hybrid optimized MRF-based lung lobe segmentation and lung cancer classification using Shufflenet", Multimedia Tools and Applications, 83(17), pp.52335-52364, (2024).
23- B. Mostafa, M. Sakr and A. Keshk, "Employing the Capabilities of LSTM and Bi-LSTM for Lung Cancer Detection and Classification", International Journal of Intelligent Engineering & Systems, 17(5), (2024).
24- R. Patnaik, P.S. Rath, S. Padhy and S. Dash, "Enhancing Lung Cancer Diagnosis through Advanced CT Scan Image Analysis: A Novel Approach using Mask-EffNet", Nanotechnology Perceptions, pp.1-26, (2024).
25- V.K. Gugulothu and S. Balaji, "An early prediction and classification of lung nodule diagnosis on CT images based on hybrid deep learning techniques", Multimedia Tools and Applications, vol. 83(1), pp.1041-1061, (2024).
26- N. Venkatesan, S. Pasupathy and B. Gobinathan, "An efficient lung cancer detection using optimal SVM and improved weight-based beetle swarm optimization", Biomedical Signal Processing and Control, vol.88, p.105373, (2024).
27- Qadir, Abdalbasit Mohammed, Peshraw Ahmed Abdalla, and Dana Faiq Abd. "A Hybrid Lung Cancer Model for Diagnosis and Stage Classification from Computed Tomography Images", Iraqi Journal for Electrical and Electronic Engineering,
28- V. Deepa and P.M. Fathimal, "Deep-Shrimp Net fostered lung cancer classification from CT images", Int. J. Image Graph. Signal Process. Vol. 15(4), pp.59-68, (2023).
29- S. Majumder, N. Gautam, A. Basu, A. Sau, Z.W. Geem and R. Sarkar, "MENet: A Mitscherlich function-based ensemble of CNN models to classify lung cancer using CT scans", Plos one, vol. 19(3), p.e0298527, (2024).
30- R. Parveen, U. Saleem, K. Abid and N. Aslam, "Identification of Lung Cancer by using Watershed Machine Learning Algorithm", VFAST Transactions on Software Engineering, vol. 11(2), pp.70-79, (2023).
31- K. Khaliq, A. Naeem, N. Aslam, A. Malik and K. Abid, "LCCNet: a deep learning based Method for the identification of lung Cancer using CT scans", VFAST Transactions on Software Engineering, vol. 11(2), pp.80-93, (2023).
32- R.J. Suji, W.W. Godfrey and J. Dhar, "Exploring pretrained encoders for lung nodule segmentation task using LIDC-IDRI dataset", Multimedia Tools and Applications, vol. 83(4), pp.9685-9708, (2024).
33- M.H. Alshayeji and S.E. Abed, "Lung cancer classification and identification framework with automatic nodule segmentation screening using machine learning", Applied Intelligence, vol. 53(16), pp.19724-19741, (2023).
34- I. Naseer, T. Masood, S. Akram, Z. Ali, A. Ahmad, S.U. Rehman and A. Jaffar, "Empowering diagnosis: cutting-edge segmentation and classification in lung cancer analysis", Computers, Materials and Continua, vol. 79(3), pp.4963-4977, (2024).
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IssueVol 13 No 3 (2026) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/fbt.v13i3.22752
Keywords
Lung Cancer Computed Tomography Data Augmentation Enhanced ResNeXt Modified ShuffleNetV2

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How to Cite
1.
Dusari SR, Challa NP. Improving Early Detection and Diagnosis of Lung Cancer using Enhanced Ensemble Deep Learning Model on CT images. Frontiers Biomed Technol. 2026;13(3):787-811.