A Dosimetric Evaluation of VMAT versus IMRT for Unilateral Lung Cancer Treatment
-
Nazar Adnan Mohammed
,
Siham Sabah Abdullah
,
Sabbar Shukri Al-Bayaty
,
Mustafa I. Ahmed Aldulaimy
,
Abdulrahman Mohammed Abdulbaqi
,
Nabaa Mohammed Alazawy
Abstract
Background: A very effective treatment for lung cancer is radiation therapy. The goal of this study was to find a better way to treat lung cancer with radiation, and it did so by combining three different types of radiation: conventional radiation treatment, intensity-modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT).
Patients and methods: Thirty people with a diagnosis of unilateral lung cancer participated in this study. Patients were treated using ELEKTA's linear accelerator with 6 MV or 10 MV energy x-ray photon beams. To plan their therapies, the patients underwent a CT simulation using MONACO version 5.1.
Results: In the comparison of VMAT with IMRT, the former demonstrates superiority in several aspects, including enhanced protection of the heart and spinal cord, reduced segments and monitoring units, and more comprehensive coverage of the projected target volume (PTV).
Conclusion: VMAT demonstrates superior results compared to IMRT in administering radiation to lung tumors while preserving the heart and spinal cord.
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19- Palma D, Vollans E, James K, Nakano S, Moiseenko V, Shaffer R, et al. "Volumetric Modulated Arc Therapy for Delivery of Prostate Radiotherapy: Comparison With IMRT and 3D-CRT." Int J Radiat Oncol Biol Phys.;72(4):996–1001(2008).
20- Verbakel WF, Cuijpers JP, Hoffmans D, Bieker M, Slotman BJ, Senan S. "Volumetric intensity-modulated arc therapy vs. conventional IMRT in head-and-neck cancer: a comparative planning and dosimetric study." Int J Radiat Oncol Biol Phys.;74(1):252–9, (2009).
21- Wu QJ, Yoo S, Kirkpatrick JP, Thongphiew D, Yin FF. "Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment." Int J Radiat Oncol Biol Phys.;75(5):1596–604, (2009).
22- Scorsetti M, Navarria P, Mancosu P, Alongi F, Castiglioni S, Cavina R, et al. "Large volume unresectable locally advanced non-small cell lung cancer: acute toxicity and initial outcome results with rapid arc." Radiat Oncol.; 5:94, (2010).
23- Kupelian PA, Ciezki J, Reddy CA, Klein EA, Mahadevan A. Effect of increasing radiation doses on local and distant failures in patients with localized prostate cancer." Int J Radiat Oncol Biol Phys.;71(1):16–22, (2008).
24- Wolff D, Stieler F, Welzel G, Lorenz F, Abo-Madyan Y, Mai S, et al. "VMAT vs. serial tomotherapy, step-and-shoot IMRT, and 3D-CRT for treatment of prostate cancer." Radiother Oncol.;93(2):226–33, (2009).
25- Bratengeier K. "2-Step IMAT and 2-Step IMRT in three dimensions." Med Phys.;32(12):3849–61, (2005).
26- McGrath SD, Matuszak MM, Yan D, Kestin LL, Martinez AA, Grills IS. "Volumetric modulated arc therapy for delivery of hypofractionated stereotactic lung radiotherapy: A dosimetric and treatment efficiency analysis." Radiother Oncol.;95(2):153–7, (2010).
27- Li Y, Wang J, Tan L, Hui B, Ma X, Yan Y, et al. "Dosimetric comparison between IMRT and VMAT in irradiation for peripheral and central lung cancer." Oncol Lett.;15(3):3735–45, (2018).
2- Parkin DM, Bray FI, Devesa SS. "Cancer burden in the year 2000. The global picture." Eur J Cancer.;37(Suppl 8): S4–66, (2001).
3- Sami S, Hameed BS, Alazawy NM, Al-Musawi MJ. "Measurements of Electron Beam Dose Distributions in Perspex Block for Different Field Sizes." J Phys Conf Ser.;1829(1), (2021).
4- Alazawy NMA, Almusawi MS, Alabedi HH, Faraj MK, Ahmad R, Albosaabar MH. "Gamma Knife Versus Volumetric Arc Modulated Therapy in a Linear Accelerator in Treatment of Multiple Brain Metastasis: Literature Review." Journal of Pioneering Medical Science.;13(2):93–100, (2024).
5- Jubbier ON, Abdullah SS, Alabedi HH, Alazawy NM, Al-Musawi MJ. "The Effect of Modulation Complexity Score (MCS) on the IMRT Treatment Planning Delivery Accuracy." J Phys Conf Ser.;1829(1):012017, (2021).
6- Hiba A-H, Zainab Raad S, Hayder Kadhim E, Mustafa Ibrahim Ahmed A, Hiyam AA. Optimisation of Acquisition Time Affecting Image Quality in Adrenal Carcinoma by PET/CT Scan. Frontiers in Biomedical Technologies.;12(4), 757-63, (2025).
7- Sonke JJ, Belderbos J. "Adaptive radiotherapy for lung cancer." Semin Radiat Oncol.;20(2):94–106, (2010).
8- Salih Khudair DA, Obaid Alabedi HH, Ali Ahmed Alazawy NM. "Multi-segments conformal plan optimization for head and neck cancer." J Pak Med Assoc.;74(10 (Supple-8)):S10–S2, (2024).
9- Videtic GMM, Stephans K, Reddy C, Gajdos S, Kolar M, Clouser E, et al. "Intensity-modulated radiotherapy-based stereotactic body radiotherapy for medically inoperable early-stage lung cancer: excellent local control." Int J Radiat Oncol Biol Phys.;77(2):344–9, (2010).
10- Jwair MG, Obaid Alabedi HH, Abdullah SS, AlHussien MK, Aliu Alazawy NM. "The accuracy of the cone beam computed tomography (CBCT) technique as an image-guided radiation therapy (IGRT) technique." J Pak Med Assoc.;74(10 (Supple-8)):S255–S8, (2024).
11- Brock J, Bedford J, Partridge M, McDonald F, Ashley S, McNair HA, et al. Optimising stereotactic body radiotherapy for non-small cell lung cancer with volumetric intensity-modulated arc therapy--a planning study. Clin Oncol (R Coll Radiol);24(1):68–75, (2012).
12- Cai J, Malhotra HK, Orton CG. Point/Counterpoint. "A 3D-conformal technique is better than IMRT or VMAT for lung SBRT." Med Phys.;41(4):040601, (2014).
13- Khalaf AM, Basim Khalaf R. "Study the Quality of IMRT and VMAT Treatment Planning Techniques (TPS) Using Indices of Achievement (IOA) Nasopharyngeal Cancer Plans." Ibn Al-Haitham Journal For Pure and Applied Sciences.;37(1), (2024).
14- Bentzen SM, Constine LS, Deasy JO, Eisbruch A, Jackson A, Marks LB, et al. "Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): An Introduction to the Scientific Issues." Int J Radiat Oncol Biol Phys.;76(3 SUPPL), (2010).
15- Hodapp N. "[The ICRU Report 83: prescribing, recording and reporting photon-beam IMRT]." Strahlenther Onkol.;188(1):97–9, (2012).
16- Jiang X, Li T, Liu Y, Zhou L, Xu Y, Zhou X, et al. "Planning analysis for locally advanced lung cancer: dosimetric and efficiency comparisons between intensity-modulated radiotherapy (IMRT), single-arc/partial-arc volumetric modulated arc therapy (SA/PA-VMAT)." Radiat Oncol.; 6:140, (2011).
17- Hernando ML, Marks LB, Bentel GC, Zhou SM, Hollis D, Das SK, et al. "Radiation-induced pulmonary toxicity: A dose-volume histogram analysis in 201 patients with lung cancer." Int J Radiat Oncol Biol Phys.;51(3):650–9, (2001).
18- Cozzi L, Dinshaw KA, Shrivastava SK, Mahantshetty U, Engineer R, Deshpande DD, et al. A treatment planning study comparing volumetric arc modulation with RapidArc and fixed field IMRT for cervix uteri radiotherapy. Radiother Oncol.;89(2):180–91, (2008).
19- Palma D, Vollans E, James K, Nakano S, Moiseenko V, Shaffer R, et al. "Volumetric Modulated Arc Therapy for Delivery of Prostate Radiotherapy: Comparison With IMRT and 3D-CRT." Int J Radiat Oncol Biol Phys.;72(4):996–1001(2008).
20- Verbakel WF, Cuijpers JP, Hoffmans D, Bieker M, Slotman BJ, Senan S. "Volumetric intensity-modulated arc therapy vs. conventional IMRT in head-and-neck cancer: a comparative planning and dosimetric study." Int J Radiat Oncol Biol Phys.;74(1):252–9, (2009).
21- Wu QJ, Yoo S, Kirkpatrick JP, Thongphiew D, Yin FF. "Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment." Int J Radiat Oncol Biol Phys.;75(5):1596–604, (2009).
22- Scorsetti M, Navarria P, Mancosu P, Alongi F, Castiglioni S, Cavina R, et al. "Large volume unresectable locally advanced non-small cell lung cancer: acute toxicity and initial outcome results with rapid arc." Radiat Oncol.; 5:94, (2010).
23- Kupelian PA, Ciezki J, Reddy CA, Klein EA, Mahadevan A. Effect of increasing radiation doses on local and distant failures in patients with localized prostate cancer." Int J Radiat Oncol Biol Phys.;71(1):16–22, (2008).
24- Wolff D, Stieler F, Welzel G, Lorenz F, Abo-Madyan Y, Mai S, et al. "VMAT vs. serial tomotherapy, step-and-shoot IMRT, and 3D-CRT for treatment of prostate cancer." Radiother Oncol.;93(2):226–33, (2009).
25- Bratengeier K. "2-Step IMAT and 2-Step IMRT in three dimensions." Med Phys.;32(12):3849–61, (2005).
26- McGrath SD, Matuszak MM, Yan D, Kestin LL, Martinez AA, Grills IS. "Volumetric modulated arc therapy for delivery of hypofractionated stereotactic lung radiotherapy: A dosimetric and treatment efficiency analysis." Radiother Oncol.;95(2):153–7, (2010).
27- Li Y, Wang J, Tan L, Hui B, Ma X, Yan Y, et al. "Dosimetric comparison between IMRT and VMAT in irradiation for peripheral and central lung cancer." Oncol Lett.;15(3):3735–45, (2018).
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How to Cite
1.
Mohammed NA, Abdullah S, Al-Bayaty S, Aldulaimy M, Abdulbaqi A, Mohammed Alazawy N. A Dosimetric Evaluation of VMAT versus IMRT for Unilateral Lung Cancer Treatment. Frontiers Biomed Technol. 2026;.
