Light-Emitting Diode Based Photoacoustic Imaging System
Abstract
Purpose: A Photoacoustic Imaging (PAI) as a non-invasive hybrid imaging modality has the potential to be used in a wide range of pre-clinical and clinical applications. There are different optical excitation sources that affect the performance of PAI systems. Our goal is proving the capability of the Light-Emitting Diode (LED) based PAI system for imaging of objects in different depths.
Materials and Methods: In this study the Full Width of Half Maximum (FWHM) and Contrast to Noise Ratio (CNR) of LED-based PAI system is evaluated using agar, and Poly-Vinyl Alcohol Cryogel (PVA-C) phantoms.
Results: The results show that axial and lateral FWHM of the photoacoustic image in agar phantom 1%, are 0.59 and 1.16 mm, respectively. It is capable of distinguishing objects about 250 µm. Furthermore, one of the main improvements of photoacoustic images is achieved by proposed LED-based system that is a 26% higher CNR versus the ultrasound images.
Conclusion: Therefore, the provided technical characteristics in this study have made designed LED-based PAI system as a suitable tool for preclinical and clinical imaging.
2- J.-W. Kim, E. I. Galanzha, E. V. Shashkov, H.-M. Moon, and V. P. Zharov, "Golden carbon nanotubes as multimodal photoacoustic and photothermal high contrast molecular agents," Nature nanotechnology, vol. 4, no. 10, p. 688, 2009.
3- M. Mehrmohammadi, S. Joon Yoon, D. Yeager, and S. Y Emelianov, "Photoacoustic imaging for cancer detection and staging," Current molecular imaging, vol. 2, no. 1, pp. 89-105, 2013.
4- S. Arabpou, E. Najafzadeh, P. Farnia, A. Ahmadian, H. Ghadiri, and M. S. A. Akhoundi, "Detection of Early Stages Dental Caries Using Photoacoustic Signals: The Simulation Study," Frontiers in Biomedical Technologies, 2019.
5- E. Najafzadeh, H. Ghadiri, M. Alimohamadi, P. Farnia, M. Mehrmohammadi, and A. Ahmadian, "Application of multi-wavelength technique for photoacoustic imaging to delineate tumor margins during maximum-safe resection of glioma: A preliminary simulation study," Journal of Clinical Neuroscience, 2019.
6- J. Kang et al., "Enhanced performance of a molecular photoacoustic imaging agent by encapsulation in mesoporous silicon nanoparticles," Advanced Materials, vol. 30, no. 27, p. 1800512, 2018.
7- P. Beard, "Biomedical photoacoustic imaging," Interface focus, vol. 1, no. 4, pp. 602-631, 2011.
8- L. V. Wang and J. Yao, "A practical guide to photoacoustic tomography in the life sciences," Nature methods, vol. 13, no. 8, p. 627, 2016.
9- Ghadiri H, Fouladi MR, Rahmim A. An Analysis Scheme for Investigation of Effects of Various Parameters on Signals in Acoustic-Resolution Photoacoustic Microscopy of Mice Brain: a Simulation Study. Frontiers Biomed Technol. vol. 4, no. (3-4), pp. 59-69, 2017.
10- E. Najafzadeh, H. Ghadiri, M. Alimohamadi, P. Farnia, M. Mehrmohammadi, and A. Ahmadian, "Evaluation of multi-wavelengths LED-based photoacoustic imaging for maximum safe resection of glioma: a proof of concept study," International Journal of Computer Assisted Radiology and Surgery, 2020/05/25 2020.
11- M. Erfanzadeh and Q. Zhu, "Photoacoustic imaging with low-cost sources; A review," Photoacoustics, 2019.
12- A. Hariri et al., "Development of low-cost photoacoustic imaging systems using very low-energy pulsed laser diodes," Journal of biomedical optics, vol. 22, no. 7, p. 075001, 2017.
13- A. Hariri, J. Lemaster, J. Wang, A. S. Jeevarathinam, D. L. Chao, and J. V. Jokerst, "The characterization of an economic and portable LED-based photoacoustic imaging system to facilitate molecular imaging," Photoacoustics, vol. 9, pp. 10-20, 2018.
14- T. J. Allen and P. C. Beard, "High power visible light emitting diodes as pulsed excitation sources for biomedical photoacoustics," Biomedical optics express, vol. 7, no. 4, pp. 1260-1270, 2016.
15- M. Zafar, K. Kratkiewicz, R. Manwar, and M. Avanaki, "Development of Low-Cost Fast Photoacoustic Computed Tomography: System Characterization and Phantom Study," Applied Sciences, vol. 9, no. 3, p. 374, 2019.
16- A. Fatima et al., "Review of cost reduction methods in photoacoustic computed tomography," Photoacoustics, p. 100137, 2019.
17- P. Farnia, A. Ahmadian, A. Khoshnevisan, A. Jaberzadeh, N. D. Serej, and A. F. Kazerooni, "An efficient point based registration of intra-operative ultrasound images with MR images for computation of brain shift; A phantom study," in Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE, pp. 8074-8077: IEEE, 2011.
18- Farnia P, Ahmadian A, Sedighpoor M, Khoshnevisan A, Mansoory MS. "On the performance of improved ICP algorithms for registration of intra-ultrasound with pre MR images; a phantom study". Engineering in Medicine and Biology Society, EMBC, 2012 Annual International Conference of the IEEE; pp. 4390–4393, 2012.
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| Issue | Vol 7 No 3 (2020) | |
| Section | Technical Note | |
| DOI | https://doi.org/10.18502/fbt.v7i3.4623 | |
| Keywords | ||
| Photoacoustic Imaging Light Emitting Diode Based Photoacoustic Phantom Imaging | ||
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