Finite Element Analysis of Cell Killing Probability in Electroporation with Single Bipolar Electrode
Abstract
In the electroporation we can use different electrode types such as needle and plate electrode with different arrangements. One of the new electrode types is single bipolar electrode which the anode and cathode components are in the same needle for decreasing the invasiveness of electroporation procedure. For treatment planning purposes we can use different cell killing probability models such as Peleg-Fermi model. The aim of this study is, investigate the impact of geometric electrode parameters such as conductive pole length, insulated pole length and pulse voltage in bipolar electrode on the cell killing probability distribution in electroporation by COMSOL Multiphysics. The target tissue volume with cell killing probability >80% increased with conductive pole length, and voltage and decreased with insulated pole length. This paper has highlighted the importance of conductive and insulated pole length and voltage in bipolar electrode on the cell killing probability distribution and electroporated volume in the EP.
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14- A. Golberg and B. Rubinsky, “A statistical model for multidimensional irreversible electroporation cell death in tissue,” Biomed. Eng. Online, vol. 9, no. 1, p. 13, 2010.
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17- A. Khorasani, S. M. Firoozabadi, and Z. Shankayi, “Conductivity Changes of Liver Tissue during Irreversible Electroporation and Calculation of the Electric Field Distribution,” Modares J. Biotechnol., vol. 9, no. 2, pp. 227–232, 2018.
18- A. Khorasani, S. M. Firoozabadi, and Z. Shankayi, “Conductivity change with needle electrode during high frequency irreversible electroporation: a finite element study,” Polish J. Med. Phys. Eng., vol. 25, no. 4, pp. 237–242, 2019.
19- S. M. Firoozabadi, “Finite Element Analysis of Tissue Conductivity during High-frequency and Low-voltage Irreversible Electroporation,” Iran. J. Med. Phys., vol. 14, no. 3, pp. 135–140, 2017.
2- L. F. Cima and L. M. Mir, “Macroscopic characterization of cell electroporation in biological tissue based on electrical measurements,” Appl. Phys. Lett., vol. 85, no. 19, pp. 4520–4522, 2004.
3- C. Y. Calvet and L. M. Mir, “The promising alliance of anti-cancer electrochemotherapy with immunotherapy,” Cancer Metastasis Rev., vol. 35, no. 2, pp. 165–177, 2016.
4- D. O. H. Suzuki, C. M. G. Marques, and M. M. M. Rangel, “Conductive gel increases the small tumor treatment with electrochemotherapy using needle electrodes,” Artif. Organs, vol. 40, no. 7, pp. 705–711, 2016.
5- B. Rubinsky, G. Onik, and P. Mikus, “Irreversible electroporation: a new ablation modality—clinical implications,” Technol. Cancer Res. Treat., vol. 6, no. 1, pp. 37–48, 2007.
6- H. J. Scheffer et al., “Irreversible electroporation for nonthermal tumor ablation in the clinical setting: a systematic review of safety and efficacy,” J. Vasc. Interv. Radiol., vol. 25, no. 7, pp. 997–1011, 2014.
7- O. Adeyanju, H. Al-Angari, and A. Sahakian, “The optimization of needle electrode number and placement for irreversible electroporation of hepatocellular carcinoma,” Radiol. Oncol., vol. 46, no. 2, pp. 126–135, 2012.
8- S. Čorović, M. Pavlin, and D. Miklavčič, “Analytical and numerical quantification and comparison of the local electric field in the tissue for different electrode configurations,” Biomed. Eng. Online, vol. 6, no. 1, p. 37, 2007.
9- A. Khorasani, “A numerical study on the effect of conductivity change in cell kill distribution in irreversible electroporation,” Polish J. Med. Phys. Eng., vol. 26, no. 2, pp. 69–76, 2020.
10- P. A. Garcia, B. Kos, J. H. Rossmeisl Jr, D. Pavliha, D. Miklavčič, and R. V Davalos, “Predictive therapeutic planning for irreversible electroporation treatment of spontaneous malignant glioma,” Med. Phys., vol. 44, no. 9, pp. 4968–4980, 2017.
11- A. Wandel et al., “Optimizing irreversible electroporation ablation with a bipolar electrode,” J. Vasc. Interv. Radiol., vol. 27, no. 9, pp. 1441–1450, 2016.
12- F. Pedersoli et al., “Single-needle electroporation and interstitial electrochemotherapy: in vivo safety and efficacy evaluation of a new system,” Eur. Radiol., vol. 29, no. 11, pp. 6300–6308, 2019.
13- G. Merola, “Design and characterization of a minimally invasive bipolar electrode for electroporation,” Politecnico di Torino, 2020.
14- A. Golberg and B. Rubinsky, “A statistical model for multidimensional irreversible electroporation cell death in tissue,” Biomed. Eng. Online, vol. 9, no. 1, p. 13, 2010.
15- J. Dermol and D. Miklavčič, “Predicting electroporation of cells in an inhomogeneous electric field based on mathematical modeling and experimental CHO-cell permeabilization to propidium iodide determination,” Bioelectrochemistry, vol. 100, pp. 52–61, 2014.
16- P. A. Garcia, R. V Davalos, and D. Miklavcic, “A numerical investigation of the electric and thermal cell kill distributions in electroporation-based therapies in tissue,” PLoS One, vol. 9, no. 8, p. e103083, 2014.
17- A. Khorasani, S. M. Firoozabadi, and Z. Shankayi, “Conductivity Changes of Liver Tissue during Irreversible Electroporation and Calculation of the Electric Field Distribution,” Modares J. Biotechnol., vol. 9, no. 2, pp. 227–232, 2018.
18- A. Khorasani, S. M. Firoozabadi, and Z. Shankayi, “Conductivity change with needle electrode during high frequency irreversible electroporation: a finite element study,” Polish J. Med. Phys. Eng., vol. 25, no. 4, pp. 237–242, 2019.
19- S. M. Firoozabadi, “Finite Element Analysis of Tissue Conductivity during High-frequency and Low-voltage Irreversible Electroporation,” Iran. J. Med. Phys., vol. 14, no. 3, pp. 135–140, 2017.
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| Issue | Vol 8 No 1 (2021) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/fbt.v8i1.5854 | |
| Keywords | ||
| Bipolar Electrode Cell Killing Probability Finite Element Analysis Irreversible Electroporation | ||
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How to Cite
1.
Khorasani A. Finite Element Analysis of Cell Killing Probability in Electroporation with Single Bipolar Electrode. Frontiers Biomed Technol. 2021;8(1):20-25.
