Original Article

A Comparison of Deep Learning and Pharmacokinetic Model Selection Methods in Segmentation of High-Grade Glioma


Purpose: Glioma tumor segmentation is an essential step in clinical decision making. Recently, computer-aided methods have been widely used for rapid and accurate delineation of the tumor regions. Methods based on image feature extraction can be used as fast methods, while segmentation based on the physiology and pharmacokinetic of the tissues is more accurate. This study aims to compare the performance of tumor segmentation based on these two different methods.

Materials and Methods: Nested Model Selection (NMS) based on Extended-Toft’s model was applied to 190 Dynamic Contrast-Enhanced MRI (DCE-MRI) slices acquired from 25 Glioblastoma Multiforme (GBM) patients in 70 time-points. A model with three pharmacokinetic parameters, Model 3, is usually assigned to tumor voxel based on the time-contrast concentration signal. We utilized Deep-Net as a CNN network, based on Deeplabv3+ and layers of pre-trained resnet18, which has been trained with 17288 T1-Contrast MRI slices with HGG brain tumor to predict the tumor region in our 190 DCE MRI T1 images. The NMS-based physiological tumor segmentation was considered as a reference to compare the results of tumor segmentation by Deep-Net. Dice, Jaccard, and overlay similarity coefficients were used to evaluate the tumor segmentation accuracy and reliability of the Deep tumor segmentation method.

Results: The results showed a relatively high similarity coefficient (Dice coefficient: 0.73±0.15, Jaccard coefficient: 0.66±0.17, and overlay coefficient: 0.71±0.15) between deep learning tumor segmentation and the tumor region identified by the NMS method. The results indicate that the deep learning methods may be used as accurate and robust tumor segmentation.

Conclusion: Deep learning-based segmentation can play a significant role to increase the segmentation accuracy in clinical application, if their training process is completely automatic and independent from human error.

IssueVol 8 No 1 (2021) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/fbt.v8i1.5858
Pharmacokinetic Analysis Nested Model Selection T1-Weighted Contrast Enhanced Magnetic Resonance Imaging Tumor Segmentation Deep Learning-Based Algorithm

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Dehkordi A, Sina S, Khodadadi F. A Comparison of Deep Learning and Pharmacokinetic Model Selection Methods in Segmentation of High-Grade Glioma. Frontiers Biomed Technol. 8(1):50-60.