The Role of Low Energy Electrons in Radiobiology and Cancer Treatment
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Abstract
Low energy radiation can be produced by all types of high energy radiation. Studies of low energy particle radiation help us to understand the chemistry induced by high energy radiations. Low energy electrons are capable of chemical selectivity in contrast to high energy electrons due to the large number of open dissociative channels in the former case and their resonant nature. Among different types of radiation, low energy electrons have a higher cross-section to DNA damage and they have an important role in the synergistic effect between radiation and chemotherapy anticancer agents in cancer treatment. Analysis of these combined records helps assign function of cells, identify metabolic and regulatory pathways and suggest targets for diagnostics and therapeutics identify animal models to develop new drugs, among other goals of biomedical interest.
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4- L. Sanche, “Interaction of low energy electrons with DNA: Applications to cancer radiation therapy,” Radiat. Phys. Chem., vol. 128, pp. 36–43, Nov. 2016, doi: 10.1016/J.RADPHYSCHEM.2016.05.008.
5- C. Geng, H. Paganetti, and C. Grassberger, “Prediction of Treatment Response for Combined Chemo- and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model,” Sci. Rep., vol. 7, no. 1, pp. 1–12, 2017, doi: 10.1038/s41598-017-13646-z.
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7- H. P. Wilson GD, Bentzen SM, “Biologic basis for combining drugs with radiation,” Semin Radiat Oncol, vol. 16, no. 1, pp. 2–9, 2006.
8- A. D. Bass and L. Sanche, “Reactions induced by low energy electrons in cryogenic films (Review),” Low Temp. Phys., vol. 29, pp. 202–214, 2003, doi: 10.1063/1.1542441.
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10- D. A. J. Mohammad Rezaee, Richard P. Hill, “The Exploitation of Low-Energy Electrons in Cancer Treatment,” Radiat. Res., vol. 188, no. 2, pp. 123–142, 2017.
11- Y. Zheng and L. Sanche, “Clustered DNA damages induced by 0.5 to 30 eV electrons,” Int. J. Mol. Sci., vol. 20, no. 15, 2019, doi: 10.3390/ijms20153749.
12- S. M. Pimblott and J. A. LaVerne, “Production of low-energy electrons by ionizing radiation,” Radiat. Phys. Chem., vol. 76, no. 8–9, pp. 1244–1247, 2007.
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14- B. Boudaïffa, P. Cloutier, D. Hunting, M. A. Huels, and L. Sanche, “Resonant formation of DNA strand breaks by low-energy (3 to 20 eV) electrons,” Science (80-. )., vol. 287, no. 5458, pp. 1658–1660, Mar. 2000, doi: 10.1126/science.287.5458.1658.
15- C. R. Arumainayagam, H. L. Lee, R. B. Nelson, D. R. Haines, and R. P. Gunawardane, “Low-energy electron-induced reactions in condensed matter,” Surf. Sci. Rep., vol. 65, pp. 1–44, 2010.
16- S. Jain, D. G. Hirst, and J. M. O’Sullivan, “Gold nanoparticles as novel agents for cancer therapy,” Br. J. Radiol., vol. 85, no. 1010, pp. 101–113, 2012, doi: 10.1259/bjr/59448833.
17- K. Bromma and D. B. Chithrani, “Advances in gold nanoparticle-based combined cancer therapy,” Nanomaterials, vol. 10, no. 9, pp. 1–25, 2020, doi: 10.3390/nano10091671.
18- K. Haume et al., “Gold nanoparticles for cancer radiotherapy: a review,” Cancer Nanotechnol., vol. 7, no. 1, 2016, doi: 10.1186/s12645-016-0021-x.
19- M. P. Antosh et al., “Enhancement of radiation effect on cancer cells by gold-pHLIP,” Proc. Natl. Acad. Sci. U. S. A., vol. 112, no. 17, pp. 5372–5376, 2015, doi: 10.1073/pnas.1501628112.
20- S. M. Mousavi, M. M. Gouya, R. Ramazani, M. Davanlou, N. Hajsadeghi, and Z. Seddighi, “Cancer incidence and mortality in Iran,” Ann. Oncol., vol. 20, no. 3, pp. 556–563, 2009, doi: 10.1093/annonc/mdn642.
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| Issue | Vol 7 No 4 (2020) | |
| Section | Editorial | |
| DOI | https://doi.org/10.18502/fbt.v7i4.5317 | |
| Keywords | ||
| Cancer Cross Section DNA Damage Low Energy Electrons | ||
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How to Cite
1.
Esmaili S, Allaveisi F. The Role of Low Energy Electrons in Radiobiology and Cancer Treatment. Frontiers Biomed Technol. 2020;7(4):206-210.
