Original Article

Gamma-Ray Attenuation Characteristics of Some Essential Amino Acids for 57Co, 192Ir, 18F, and 116mIn Sources

Abstract

Purpose: In different tissues of the body, proteins are important parts that are made up of building blocks called amino acids. Considering the wide applications of radioactive sources in industry and medicine, the need to study the attenuation characteristics of amino acids is determined.

Materials and Methods: To study the attenuation characteristics of five types of amino acids, MCNPX Monte Carlo code and XMuDat program were used. Linear and mass attenuation coefficients, half and tenth value layers, mean free path, effective atomic and electronic cross-sections, effective atomic numbers and effective electron densities were calculated. 57Co, 192Ir, 18F, and 116mIn gamma sources were considered for this study. To validate the theoretical results, the obtained values were compared with the available experimental data.

Results: The difference between the theoretical and experimental results was less than 11%. The results showed that with increasing photon energy, the linear and mass attenuation coefficients and effective atomic and electronic cross-sections decreased, while the half and tenth value layers and mean free path quantities increased. Furthermore, the linear attenuation coefficients, the effective atomic and electronic cross-sections, as well as the effective atomic number values increased with increasing amino acid density, while the effective electron density behaves independently of the amino acid density.

Conclusion: The presented theoretical methods produced data similar to experimental results with fair accuracy, so by using these methods, attenuation properties of other amino acids can be obtained over a wide range of energies.

1- P.P. Pawar, C.S. Mahajan, "Measurement of mass and linear attenuation coefficients of gamma-rays of glycine for 0.360, 0.662, 1.170 and 1.330 MeV photons.", Sci Res Rep, vol. 3, pp. 53–56, (2013).
2- M. Donya, M. Radford, A. ElGuindy, D. Firmin, M.H. Yacoub, "Radiation in medicine: origins, risks and aspirations.", Glob. Cardiol. Sci Pract, vol. 2014, pp. 437–448, (2014).
3- C.F. Huang, J. McConathy, "Fluorine-18 labeled amino acids for oncologic imaging with positron emission tomography.", Curr Top Med Chem, vol. 13, pp. 871–891, (2013).
4- J.B. Workman, E. Rusche, "Cobalt-57 labeled vitamin B-12 plasma levels for the differential diagnosis of macrocytic anemias.", J Nucl Med, vol. 7, pp. 583-588, (1966).
5- C.J. Hellier, "Handbook of Nondestructive Evaluation." McGraw-Hill. 3rd edition, (2003). ISBN 978-1260441437.
6- M. Blau, R. Ganatra, M.A. Bender, "18F-fluoride for bone imaging.", Semin Nucl Med, vol. 2, pp. 31–37, (1972).
7- S. Lahiri, M. Maiti, K. Ghosh, "Production and separation of 111In: An important radionuclide in life sciences: A mini review." J Radioanal Nucl Chem, vol. 297, pp. 309–318, (2013).
8- K.P.G. Nair, C. Gowda, J.S. Kumari, S.J. Anasuya, T.K. Umesh, R. Gowda, “Photon interaction cross sections for some amino acids in the range 30–385 KeV." Radiat Phys Chem, vol. 43, pp. 581–584, (1994).
9- K.P.G. Nair, T.K. Umesh, R. Gowda, "Total attenuation cross sections of several amino acids at 661.6, 1173 and 1332.5 KeV." Radiat Phys Chem, vol. 45, pp. 231–233, (1995).
10- S. Gowda, S. Krishnaveni, R. Gowda, "Studies on effective atomic numbers and electron densities in amino acids and sugars in the energy range 30–1333 keV." Nucl Instr Meth Phys Res B, vol. 239, pp. 361–369, (2005).
11- V. Manjunathaguru, T.K. Umesh, "Effective atomic numbers and electron densities of some biologically important compounds containing H, C, N and O in the energy range 145–1330 keV." J Phys B: At Mol Opt Phys, vol. 39, pp. 3969–3981, (2006).
12- B.O. Elbashir, M.G. Dong, M.I. Sayyed et al., "Comparison of Monte Carlo simulation of gamma ray attenuation coefficients of amino acids with XCOM program and experimental data." Results Phys, vol. 9, pp. 6–11, (2018).
13- R.M. Lokhande, C.V. More, B.S. Surun et al., "Determination of attenuation parameters and energy absorption build-up factor of amine group materials." Radiat Phys Chem, vol. 141, pp. 292-299, (2017).
14- C.V. More, R.M. Lokhande, P.P. Pawar, "Effective atomic number and electron density of amino acids within the energy range of 0.122–1.330 MeV.", Radiat Phys Chem, vol. 125, pp. 14–20, (2016).
15- S.R. Manohara, S.M. Hanagodimath, "Studies on effective atomic numbers and electron densities of essential amino acids in the energy range 1 KeV–100 GeV.", Nucl Instrum Methods Phys Res B, vol. 258, pp. 321–328, (2007).
16- P.P. Pawar, G.K. Bichile, "Studies on mass attenuation coefficient, effective atomic number and electron density of some amino acids in the energy range 0.122–1.330 MeV." Radiat Phys Chem, vol. 92, pp. 22–27, (2013).
17- R. Bagheri, A. Yousefi, S.P. Shirmardi, "Study on gamma-ray attenuation characteristics of some amino acids for 133Ba, 137Cs, and 60Co sources.", Nucl Sci Tech, vol. 31, pp. 1-15, (2020).
18- D.B. Pelowitz, "MCNPXTM User’s Manual." Version 2.6.0, Report LA-CP-07-1473, Los Alamos, NM: Los Alamos National Laboratory, (2008).
19- J.H. Hubbell, S.M. Seltzer, "Tables of X-Ray Mass Attenuation Coefficients and Mass Energy-Absorption Coefficients 1 KeV–20 MeV for Elements 1 20- J.M. Boone, A.E.Chavez, "Comparison of X-Ray Cross Sections for Diagnostic and Therapeutic Medical Physics.", Med Phys, vol. 23, pp. 1997–2005, (1996).
21- L. Gerward, N. Guilbert, K.B. Jensen, H. Levring, "WinXCom: a program for calculating X ray attenuation coefficients.", Radiat Phys Chem, vol. 71, pp. 653–654, (2004).
22- R. Nowotny, "XMuDat: Photon Attenuation Data on PC.", Tech. Rep. IAEA-NDS-195 (Vienna: International Atomic Energy Agency), (1998).
23- S. Sharifi, R. Bagheri, S.P. Shirmardi, "Comparison of shielding properties for ordinary, barite, serpentine and steel–magnetite concretes using MCNP-4C code and available experimental results.", Ann Nucl Energy, vol. 53, pp. 529–534, (2013).
24- K. Kirdsiri, J. Kaewkhao, N. Chanthima, P. Limsuwan, "Comparative study of silicate glasses containing Bi2O3, PbO and BaO: Radiation shielding and optical properties.", Ann Nucl Energy, vol. 38, pp. 1438-1441, (2011).
25- R. Bagheri, A.K. Moghaddam, S.P. Shirmardi, B. Azadbakht, M. Salehi, "Determination of gamma-ray shielding properties for silicate glasses containing Bi2O3, PbO, and BaO.", J Non-Cryst Solids, vol. 479, pp. 62–71, (2018).
26- A. Turşucu, P. Önder, D. Demir, T. Öznülüer, "Studies on mass attenuation coefficient, effective atomic number and electron density of some amino acids." Int J Phys Sci, vol. 8, pp. 147-156, (2013).
27- S. Manohara, S.Hanagodimath, "Effective atomic numbers for photon energy absorption of essential amino acids in the energy range 1 keV to 20 MeV.", Nucl Instrum Methods Phys Res B, vol. 264, pp. 9-14, (2007).
28- S. Manohara, S. Hanagodimath, K. Thind, L. Gerward, "On the effective atomic number and electron density: A comprehensive set of formulas for all types of materials and energies above 1 keV.", Nucl Instrum Methods Phys Res B, vol. 266, pp. 3906-3912, (2008).
Files
IssueVol 9 No 1 (2022) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/fbt.v9i1.8142
Keywords
Amino Acid Linear Attenuation Coefficient Effective Electron Density XMuDat Program Monte Carlo N-Particle eXtended Code

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Bagheri R, Khorrami A. Gamma-Ray Attenuation Characteristics of Some Essential Amino Acids for 57Co, 192Ir, 18F, and 116mIn Sources. Frontiers Biomed Technol. 2021;9(1):29-37.