Comparison of Two Electrode Placement Methods in Transcranial Direct Current Stimulation for Parkinson's Disease
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Abstract
Purpose: Therapeutic electrical stimulation of deep brain structures, such as the subthalamic nucleus and the Globus Pallidus (GP), is widely accepted as a treatment tool for patients with Parkinson's Disease (PD). Electrical stimulation of the cerebral cortex with electrodes or transcranial stimulation can increase motor function among PD patients. The present study aimed to evaluate the effects of non-invasive cortical stimulation with simulation of transcranial Direct Current Stimulation (tDCS) technique on parts of the basal ganglia among PD patients.
Materials and Methods: tDCS was simulated using two different electrode placement methods (anodal stimulation of the primary motor cortex (M1) and anodal stimulation of the Dorsolateral Prefrontal Cortex (DLPFC)) and We evaluated the excitation procedure in the target area based on the excitation current distribution in GP and Subthalamic Nucleus according to the patient's condition in both electrode methods. All simulations were performed using head Magnetic Resonance Imaging (MRI) images of four people with PD. Also, according to the excitation current distribution obtained from the previous step, we studied how the excitation current distributed in the target areas is affected by using a model of the basal ganglia so that based on the membrane potential of each excitation in these areas, in all four patients, we compare both electrode-installation methods in a functional way. The effectiveness of brain stimulation was also studied using a basal ganglia model. Considering the membrane potential of GP and Subthalamic Nucleus regions, the effectiveness of each electrode placement method was evaluated in the Basal Ganglia )BG( model.
Results: According to the results, direct current stimulation was propagated through electrodes placed on the scalp throughout the model. Also, anodal stimulation of the M1 had a better stimulation of GP and subthalamic nucleus than anodal stimulation of the DLPFC.
Conclusion: Although, the procedures for performing tDCS and invasive brain stimulation in PD are different, the results show that this treatment can be appropriate and improve motor function in patients with PD.
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3- Yousef Salimpour, Zoltan K Mari, and Reza Shadmehr, "Altering effort costs in Parkinson's disease with noninvasive cortical stimulation." Journal of Neuroscience, Vol. 35 (No. 35), pp. 12287-302, (2015).
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5- Rosa Manenti et al., "Time up and go task performance improves after transcranial direct current stimulation in patient affected by Parkinson's disease." Neuroscience letters, Vol. 580pp. 74-77, (2014).
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7- Vida Alizad, Marcus Meinzer, Laurent Frossard, Remco Polman, Simon Smith, and Graham Kerr, "Effects of transcranial direct current stimulation on gait in people with Parkinson’s disease: study protocol for a randomized, controlled clinical trial." Trials, Vol. 19 (No. 1), pp. 1-12, (2018).
8- Deniz Doruk, Zachary Gray, Gabriela L Bravo, Alvaro Pascual-Leone, and Felipe Fregni, "Effects of tDCS on executive function in Parkinson's disease." Neuroscience letters, Vol. 582pp. 27-31, (2014).
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10- Rubén Hernández de Paz, Diego Serrano-Muñoz, Soraya Pérez-Nombela, Elisabeth Bravo-Esteban, Juan Avendaño-Coy, and Julio Gómez-Soriano, "Combining transcranial direct-current stimulation with gait training in patients with neurological disorders: a systematic review." Journal of neuroengineering and rehabilitation, Vol. 16 (No. 1), pp. 1-8, (2019).
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14- Beatrix Krause and Roi Cohen Kadosh, "Not all brains are created equal: the relevance of individual differences in responsiveness to transcranial electrical stimulation." Frontiers in systems neuroscience, Vol. 8p. 25, (2014).
15- Berkan Guleyupoglu, Pedro Schestatsky, Dylan Edwards, Felipe Fregni, and Marom Bikson, "Classification of methods in transcranial electrical stimulation (tES) and evolving strategy from historical approaches to contemporary innovations." Journal of neuroscience methods, Vol. 219 (No. 2), pp. 297-311, (2013).
16- Felipe Fregni et al., "Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease." Movement disorders, Vol. 21 (No. 10), pp. 1693-702, (2006).
17- Marcin Zygmunt Zarzycki and Izabela Domitrz, "Stimulation-induced side effects after deep brain stimulation–a systematic review." Acta Neuropsychiatrica, Vol. 32 (No. 2), pp. 57-64, (2020).
18- L Chaieb, D Terney, V Moliadze, W Paulus, and A Antal, "Increasing Human Brain Excitability by Transcranial High-Frequency Random Noise Stimulation." NeuroImage, (No. 47), p. S151, (2009).
19- Anna Fertonani, Cornelia Pirulli, and Carlo Miniussi, "Random noise stimulation improves neuroplasticity in perceptual learning." Journal of Neuroscience, Vol. 31 (No. 43), pp. 15416-23, (2011).
20- Jingying Wang, Huichun Luo, Rasmus Schülke, Xinyi Geng, Barbara J Sahakian, and Shouyan Wang, "Is transcranial direct current stimulation, alone or in combination with antidepressant medications or psychotherapies, effective in treating major depressive disorder? A systematic review and meta-analysis." BMC medicine, Vol. 19 (No. 1), pp. 1-14, (2021).
21- Marina Zettin, Caterina Bondesan, Giulia Nada, Matteo Varini, and Danilo Dimitri, "Transcranial Direct-Current Stimulation and Behavioral Training, a Promising Tool for a Tailor-Made Post-stroke Aphasia Rehabilitation: A Review." Frontiers in human neuroscience, Vol. 15p. 742136, (2021).
22- Roberto Monastero et al., "Transcranial random noise stimulation over the primary motor cortex in PD-MCI patients: a crossover, randomized, sham-controlled study." Journal of Neural Transmission, Vol. 127 (No. 12), pp. 1589-97, (2020).
23- Joana B Pereira et al., "Modulation of verbal fluency networks by transcranial direct current stimulation (tDCS) in Parkinson’s disease." Brain stimulation, Vol. 6 (No. 1), pp. 16-24, (2013).
24- Xiang Liu et al., "Transcranial Direct Current Stimulation for Parkinson's Disease: A Systematic Review and Meta-Analysis." Frontiers in Aging Neuroscience, p. 691, (2021).
25- D Kaski, RO Dominguez, JH Allum, AF Islam, and AM Bronstein, "Combining physical training with transcranial direct current stimulation to improve gait in Parkinson’s disease: a pilot randomized controlled study." Clinical rehabilitation, Vol. 28 (No. 11), pp. 1115-24, (2014).
26- Francesca Valentino et al., "Transcranial direct current stimulation for treatment of freezing of gait: A cross‐over study." Movement disorders, Vol. 29 (No. 8), pp. 1064-69, (2014).
27- Roberta Biundo et al., "Double-blind randomized trial of t-DCS versus sham in Parkinson patients with mild cognitive impairment receiving cognitive training." Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, Vol. 8 (No. 6), pp. 1223-25, (2015).
28- Adriana Costa-Ribeiro et al., "Dopamine-independent effects of combining transcranial direct current stimulation with cued gait training on cortical excitability and functional mobility in Parkinson’s disease." J Rehabil Med, Vol. 48 (No. 9), pp. 819-23, (2016).
29- Rosa Manenti et al., "M ild cognitive impairment in Parkinson's disease is improved by transcranial direct current stimulation combined with physical therapy." Movement disorders, Vol. 31 (No. 5), pp. 715-24, (2016).
30- Siobhan M Schabrun, Robyn M Lamont, and Sandra G Brauer, "Transcranial direct current stimulation to enhance dual-task gait training in Parkinson’s disease: a pilot RCT." PloS one, Vol. 11 (No. 6), p. e0158497, (2016).
31- Chad Swank, Jyutika Mehta, and Christina Criminger, "Transcranial direct current stimulation lessens dual task cost in people with Parkinson’s disease." Neuroscience letters, Vol. 626pp. 1-5, (2016).
32- Bijan Forogh, Maryam Rafiei, Amin Arbabi, Mohammad Reza Motamed, Seyed Pezhman Madani, and Simin Sajadi, "Repeated sessions of transcranial direct current stimulation evaluation on fatigue and daytime sleepiness in Parkinson’s disease." Neurological Sciences, Vol. 38 (No. 2), pp. 249-54, (2017).
33- Elisabeth Kaminski et al., "Transcranial direct current stimulation (tDCS) over primary motor cortex leg area promotes dynamic balance task performance." Clinical Neurophysiology, Vol. 127 (No. 6), pp. 2455-62, (2016).
34- Viola Oldrati and Dennis JLG Schutter, "Targeting the human cerebellum with transcranial direct current stimulation to modulate behavior: a meta-analysis." The Cerebellum, Vol. 17 (No. 2), pp. 228-36, (2018).
35- Alberto Pisoni, Giulia Mattavelli, Costanza Papagno, Mario Rosanova, Adenauer G Casali, and Leonor J Romero Lauro, "Cognitive enhancement induced by anodal tDCS drives circuit-specific cortical plasticity." Cerebral Cortex, Vol. 28 (No. 4), pp. 1132-40, (2018).
36- Geert Verheyden, Joanne Purdey, Malcolm Burnett, Jonathan Cole, and Ann Ashburn, "Immediate effect of transcranial direct current stimulation on postural stability and functional mobility in Parkinson's disease." Movement disorders, Vol. 28 (No. 14), pp. 2040-41, (2013).
37- Caspar Stephani, Michael A Nitsche, Martin Sommer, and Walter Paulus, "Impairment of motor cortex plasticity in Parkinson’s disease, as revealed by theta-burst-transcranial magnetic stimulation and transcranial random noise stimulation." Parkinsonism & related disorders, Vol. 17 (No. 4), pp. 297-98, (2011).
38- Sami Gabriel, RW Lau, and Camelia Gabriel, "The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz." Physics in medicine & biology, Vol. 41 (No. 11), p. 2251, (1996).
39- S Goncalve, Jan C de Munck, Jeroen PA Verbunt, Rob M Heethaar, and Fernando Henrique Lopes da Silva, "In vivo measurement of the brain and skull resistivities using an EIT-based method and the combined analysis of SEF/SEP data." IEEE Transactions on Biomedical Engineering, Vol. 50 (No. 9), pp. 1124-27, (2003).
40- Jonathan E Rubin and David Terman, "High frequency stimulation of the subthalamic nucleus eliminates pathological thalamic rhythmicity in a computational model." Journal of computational neuroscience, Vol. 16 (No. 3), pp. 211-35, (2004).
41- Rosa Q So, Alexander R Kent, and Warren M Grill, "Relative contributions of local cell and passing fiber activation and silencing to changes in thalamic fidelity during deep brain stimulation and lesioning: a computational modeling study." Journal of computational neuroscience, Vol. 32 (No. 3), pp. 499-519, (2012).
42- CD Workman, J Kamholz, and T Rudroff, "Transcranial direct current stimulation (tDCS) for the treatment of a Multiple Sclerosis symptom cluster." Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, Vol. 13 (No. 1), pp. 263-64, (2020).
43- Giulio Ruffini et al., "Transcranial current brain stimulation (tCS): models and technologies." IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol. 21 (No. 3), pp. 333-45, (2012).
2- David H Benninger et al., "Transcranial direct current stimulation for the treatment of Parkinson's disease." Journal of Neurology, Neurosurgery & Psychiatry, Vol. 81 (No. 10), pp. 1105-11, (2010).
3- Yousef Salimpour, Zoltan K Mari, and Reza Shadmehr, "Altering effort costs in Parkinson's disease with noninvasive cortical stimulation." Journal of Neuroscience, Vol. 35 (No. 35), pp. 12287-302, (2015).
4- Eduardo Lattari, Samara Sezana Costa, Carlos Campos, Aldair José de Oliveira, Sérgio Machado, and Geraldo Albuquerque Maranhao Neto, "Can transcranial direct current stimulation on the dorsolateral prefrontal cortex improves balance and functional mobility in Parkinson’s disease?" Neuroscience letters, Vol. 636pp. 165-69, (2017).
5- Rosa Manenti et al., "Time up and go task performance improves after transcranial direct current stimulation in patient affected by Parkinson's disease." Neuroscience letters, Vol. 580pp. 74-77, (2014).
6- Roberta Ferrucci, Tommaso Bocci, Francesca Cortese, Fabiana Ruggiero, and Alberto Priori, "Cerebellar transcranial direct current stimulation in neurological disease." Cerebellum & ataxias, Vol. 3 (No. 1), pp. 1-8, (2016).
7- Vida Alizad, Marcus Meinzer, Laurent Frossard, Remco Polman, Simon Smith, and Graham Kerr, "Effects of transcranial direct current stimulation on gait in people with Parkinson’s disease: study protocol for a randomized, controlled clinical trial." Trials, Vol. 19 (No. 1), pp. 1-12, (2018).
8- Deniz Doruk, Zachary Gray, Gabriela L Bravo, Alvaro Pascual-Leone, and Felipe Fregni, "Effects of tDCS on executive function in Parkinson's disease." Neuroscience letters, Vol. 582pp. 27-31, (2014).
9- Felipe Fregni and Alvaro Pascual-Leone, "Technology insight: noninvasive brain stimulation in neurology—perspectives on the therapeutic potential of rTMS and tDCS." Nature clinical practice Neurology, Vol. 3 (No. 7), pp. 383-93, (2007).
10- Rubén Hernández de Paz, Diego Serrano-Muñoz, Soraya Pérez-Nombela, Elisabeth Bravo-Esteban, Juan Avendaño-Coy, and Julio Gómez-Soriano, "Combining transcranial direct-current stimulation with gait training in patients with neurological disorders: a systematic review." Journal of neuroengineering and rehabilitation, Vol. 16 (No. 1), pp. 1-8, (2019).
11- Víctor Navarro-López, Manuel del Valle-Gratacós, Rubén Fernández-Matías, María Carratalá-Tejada, Alicia Cuesta-Gómez, and Francisco Molina-Rueda, "The Long-Term Maintenance of Upper Limb Motor Improvements Following Transcranial Direct Current Stimulation Combined with Rehabilitation in People with Stroke: A Systematic Review of Randomized Sham-Controlled Trials." Sensors, Vol. 21 (No. 15), p. 5216, (2021).
12- Syed Salman Shahid, Marom Bikson, Humaira Salman, Peng Wen, and Tony Ahfock, "The value and cost of complexity in predictive modelling: role of tissue anisotropic conductivity and fibre tracts in neuromodulation." Journal of neural engineering, Vol. 11 (No. 3), p. 036002, (2014).
13- H Thair, AL Holloway, R Newport, and AD Smith, "Transcranial direct current stimulation (tDCS): a beginner's guide for design and implementation. Front Neurosci 2017; 11: 641." PubMed: https://pubmed. ncbi. nlm. nih. gov/29213226, (2017).
14- Beatrix Krause and Roi Cohen Kadosh, "Not all brains are created equal: the relevance of individual differences in responsiveness to transcranial electrical stimulation." Frontiers in systems neuroscience, Vol. 8p. 25, (2014).
15- Berkan Guleyupoglu, Pedro Schestatsky, Dylan Edwards, Felipe Fregni, and Marom Bikson, "Classification of methods in transcranial electrical stimulation (tES) and evolving strategy from historical approaches to contemporary innovations." Journal of neuroscience methods, Vol. 219 (No. 2), pp. 297-311, (2013).
16- Felipe Fregni et al., "Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease." Movement disorders, Vol. 21 (No. 10), pp. 1693-702, (2006).
17- Marcin Zygmunt Zarzycki and Izabela Domitrz, "Stimulation-induced side effects after deep brain stimulation–a systematic review." Acta Neuropsychiatrica, Vol. 32 (No. 2), pp. 57-64, (2020).
18- L Chaieb, D Terney, V Moliadze, W Paulus, and A Antal, "Increasing Human Brain Excitability by Transcranial High-Frequency Random Noise Stimulation." NeuroImage, (No. 47), p. S151, (2009).
19- Anna Fertonani, Cornelia Pirulli, and Carlo Miniussi, "Random noise stimulation improves neuroplasticity in perceptual learning." Journal of Neuroscience, Vol. 31 (No. 43), pp. 15416-23, (2011).
20- Jingying Wang, Huichun Luo, Rasmus Schülke, Xinyi Geng, Barbara J Sahakian, and Shouyan Wang, "Is transcranial direct current stimulation, alone or in combination with antidepressant medications or psychotherapies, effective in treating major depressive disorder? A systematic review and meta-analysis." BMC medicine, Vol. 19 (No. 1), pp. 1-14, (2021).
21- Marina Zettin, Caterina Bondesan, Giulia Nada, Matteo Varini, and Danilo Dimitri, "Transcranial Direct-Current Stimulation and Behavioral Training, a Promising Tool for a Tailor-Made Post-stroke Aphasia Rehabilitation: A Review." Frontiers in human neuroscience, Vol. 15p. 742136, (2021).
22- Roberto Monastero et al., "Transcranial random noise stimulation over the primary motor cortex in PD-MCI patients: a crossover, randomized, sham-controlled study." Journal of Neural Transmission, Vol. 127 (No. 12), pp. 1589-97, (2020).
23- Joana B Pereira et al., "Modulation of verbal fluency networks by transcranial direct current stimulation (tDCS) in Parkinson’s disease." Brain stimulation, Vol. 6 (No. 1), pp. 16-24, (2013).
24- Xiang Liu et al., "Transcranial Direct Current Stimulation for Parkinson's Disease: A Systematic Review and Meta-Analysis." Frontiers in Aging Neuroscience, p. 691, (2021).
25- D Kaski, RO Dominguez, JH Allum, AF Islam, and AM Bronstein, "Combining physical training with transcranial direct current stimulation to improve gait in Parkinson’s disease: a pilot randomized controlled study." Clinical rehabilitation, Vol. 28 (No. 11), pp. 1115-24, (2014).
26- Francesca Valentino et al., "Transcranial direct current stimulation for treatment of freezing of gait: A cross‐over study." Movement disorders, Vol. 29 (No. 8), pp. 1064-69, (2014).
27- Roberta Biundo et al., "Double-blind randomized trial of t-DCS versus sham in Parkinson patients with mild cognitive impairment receiving cognitive training." Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, Vol. 8 (No. 6), pp. 1223-25, (2015).
28- Adriana Costa-Ribeiro et al., "Dopamine-independent effects of combining transcranial direct current stimulation with cued gait training on cortical excitability and functional mobility in Parkinson’s disease." J Rehabil Med, Vol. 48 (No. 9), pp. 819-23, (2016).
29- Rosa Manenti et al., "M ild cognitive impairment in Parkinson's disease is improved by transcranial direct current stimulation combined with physical therapy." Movement disorders, Vol. 31 (No. 5), pp. 715-24, (2016).
30- Siobhan M Schabrun, Robyn M Lamont, and Sandra G Brauer, "Transcranial direct current stimulation to enhance dual-task gait training in Parkinson’s disease: a pilot RCT." PloS one, Vol. 11 (No. 6), p. e0158497, (2016).
31- Chad Swank, Jyutika Mehta, and Christina Criminger, "Transcranial direct current stimulation lessens dual task cost in people with Parkinson’s disease." Neuroscience letters, Vol. 626pp. 1-5, (2016).
32- Bijan Forogh, Maryam Rafiei, Amin Arbabi, Mohammad Reza Motamed, Seyed Pezhman Madani, and Simin Sajadi, "Repeated sessions of transcranial direct current stimulation evaluation on fatigue and daytime sleepiness in Parkinson’s disease." Neurological Sciences, Vol. 38 (No. 2), pp. 249-54, (2017).
33- Elisabeth Kaminski et al., "Transcranial direct current stimulation (tDCS) over primary motor cortex leg area promotes dynamic balance task performance." Clinical Neurophysiology, Vol. 127 (No. 6), pp. 2455-62, (2016).
34- Viola Oldrati and Dennis JLG Schutter, "Targeting the human cerebellum with transcranial direct current stimulation to modulate behavior: a meta-analysis." The Cerebellum, Vol. 17 (No. 2), pp. 228-36, (2018).
35- Alberto Pisoni, Giulia Mattavelli, Costanza Papagno, Mario Rosanova, Adenauer G Casali, and Leonor J Romero Lauro, "Cognitive enhancement induced by anodal tDCS drives circuit-specific cortical plasticity." Cerebral Cortex, Vol. 28 (No. 4), pp. 1132-40, (2018).
36- Geert Verheyden, Joanne Purdey, Malcolm Burnett, Jonathan Cole, and Ann Ashburn, "Immediate effect of transcranial direct current stimulation on postural stability and functional mobility in Parkinson's disease." Movement disorders, Vol. 28 (No. 14), pp. 2040-41, (2013).
37- Caspar Stephani, Michael A Nitsche, Martin Sommer, and Walter Paulus, "Impairment of motor cortex plasticity in Parkinson’s disease, as revealed by theta-burst-transcranial magnetic stimulation and transcranial random noise stimulation." Parkinsonism & related disorders, Vol. 17 (No. 4), pp. 297-98, (2011).
38- Sami Gabriel, RW Lau, and Camelia Gabriel, "The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz." Physics in medicine & biology, Vol. 41 (No. 11), p. 2251, (1996).
39- S Goncalve, Jan C de Munck, Jeroen PA Verbunt, Rob M Heethaar, and Fernando Henrique Lopes da Silva, "In vivo measurement of the brain and skull resistivities using an EIT-based method and the combined analysis of SEF/SEP data." IEEE Transactions on Biomedical Engineering, Vol. 50 (No. 9), pp. 1124-27, (2003).
40- Jonathan E Rubin and David Terman, "High frequency stimulation of the subthalamic nucleus eliminates pathological thalamic rhythmicity in a computational model." Journal of computational neuroscience, Vol. 16 (No. 3), pp. 211-35, (2004).
41- Rosa Q So, Alexander R Kent, and Warren M Grill, "Relative contributions of local cell and passing fiber activation and silencing to changes in thalamic fidelity during deep brain stimulation and lesioning: a computational modeling study." Journal of computational neuroscience, Vol. 32 (No. 3), pp. 499-519, (2012).
42- CD Workman, J Kamholz, and T Rudroff, "Transcranial direct current stimulation (tDCS) for the treatment of a Multiple Sclerosis symptom cluster." Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, Vol. 13 (No. 1), pp. 263-64, (2020).
43- Giulio Ruffini et al., "Transcranial current brain stimulation (tCS): models and technologies." IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol. 21 (No. 3), pp. 333-45, (2012).
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| Issue | Vol 10 No 2 (2023) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/fbt.v10i2.12222 | |
| Keywords | ||
| Parkinson’s Disease Transcranial Direct Current Stimulation Globus Pallidus Subthalamic Nucleus Basal Ganglia 3 Dimensional Model of Brain | ||
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How to Cite
1.
Moeini Kouchaksaraei MM, Nowshiravan Rahatabad F, Sheikhani A. Comparison of Two Electrode Placement Methods in Transcranial Direct Current Stimulation for Parkinson’s Disease. Frontiers Biomed Technol. 2023;10(2):180-187.
