Critical Organ Dose Estimation from Tc-99m-MIBI in Nuclear Medicine Cardiology Based on Distribution Data in Rats
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Abstract
Purpose: Calculating the organs' radiation dosage in cardiac nuclear medicine procedures is essential in order to identify critical organs, radiation risk assessment and optimization dose value in the injection of radiopharmaceutical drugs. In this study, the biological distribution of 99mTc-2-Methoxyisobutylisonitrile) 99mTc-MIBI as the most common radiopharmaceutical in a cardiac study in human organs based on animal samples was investigated.
Materials and Methods: After 99mTc-MIBI preparation, radiopharmaceutical was injected into 15 rats. After sacrificing rats, the uptake of radiopharmaceuticals in critical organs at 15, 30, and 45 minutes was measured using an High Purity Germanium (HPGE) detector and the percentage of injected dose per gram of organs was calculated. The cumulative activity was calculated from the radiopharmaceutical transformation diagram with time. The absorption of a radioactive complex in human organs based on animal data was calculated by applying a correction factor. The organs dose was calculated using S factor and the effective dose was calculated using tissue weighting factors.
Results: The mean effective dose per unit of activity was 0.0062 mSv/MBq. The mean effective dose of 27.5 mCi radiopharmaceutical injection was 6.3 mSv. In this study, the absorbed dose in blood, heart, lung, thyroid, liver, spleen, stomach wall, muscle, and bone was calculated as 0.28, 2.92, 1.85, 24.82, 11.13, 7.03, 20.95, 1.11, 4.97, and 22.22 mGy, respectively.
Conclusion: The effective dose of human organs based on the animal model in the study of cardiac nuclear medicine was evaluated by injection of 99mTc-MIBI radiopharmaceutical. The kidneys, salivary glands, thyroid, and spleen were the most critical organs that should be considered in dose optimization studies. The effective dose limit was 28% lower than the values reported in international references.
2- J Valentin, "Radiation dose to patients from radiopharmaceuticals:(Addendum 2 to ICRP Publication 53) ICRP Publication 80 Approved by the Commission in September 1997." Annals of the ICRP, Vol. 28 (No. 3), pp. 1-1, (1998).
3- Marion De Jong and Theodosia Maina, "Of mice and humans: are they the same?—Implications in cancer translational research." Journal of Nuclear Medicine, Vol. 51 (No. 4), pp. 501-04, (2010).
4- Andrew J Einstein, Kevin W Moser, Randall C Thompson, Manuel D Cerqueira, and Milena J Henzlova, "Radiation dose to patients from cardiac diagnostic imaging." Circulation, Vol. 116 (No. 11), pp. 1290-305, (2007).
5- MG Stabin and GD Flux, "Internal dosimetry as a tool for radiation protection of the patient in nuclear medicine." Biomedical Imaging and Intervention Journal, Vol. 3 (No. 2), p. e28, (2007).
6- Tianwu Xie, Choonsik Lee, Wesley E Bolch, and Habib Zaidi, "Assessment of radiation dose in nuclear cardiovascular imaging using realistic computational models." Medical physics, Vol. 42 (No. 6Part1), pp. 2955-66, (2015).
7- Timothy K Johnson, David McClure, and Steven McCourt, "MABDOSE. I: Characterization of a general purpose dose estimation code." Medical physics, Vol. 26 (No. 7), pp. 1389-95, (1999).
8- Michael G Stabin and Jeffry A Siegel, "Physical models and dose factors for use in internal dose assessment." Health physics, Vol. 85 (No. 3), pp. 294-310, (2003).
9- [Online]. Available: http://www.doseinfo-radar.com/OLINDA.html
10- Michael G Stabin, X George Xu, Mary A Emmons, W Paul Segars, Chengyu Shi, and Michael J Fernald, "RADAR reference adult, pediatric, and pregnant female phantom series for internal and external dosimetry." Journal of Nuclear Medicine, Vol. 53 (No. 11), pp. 1807-13, (2012).
11- SMO Ramos, S Thomas, MA Pinheiro, ARFB Coelho, and M Albernaz, "Internal radiation dose and modeling codes in nuclear medicine: a fresh look at old problems." Int J Radiol Radiat Ther, Vol. 4 (No. 5), p. 00111, (2017).
12- Levent Kabasakal, "Technetium-99m ethylene dicysteine: a new renal tubular function agent." European journal of nuclear medicine, Vol. 27 (No. 3), pp. 351-57, (2000).
13- Osman Günay et al., "Determination of radiation dose from patients undergoing Tc-99m Sestamibi nuclear cardiac imaging." International Journal of Environmental Science and Technology, Vol. 16 (No. 9), pp. 5251-58, (2019).
14- MANUFACTURE OF KITS, "Technetium-99m radiopharmaceuticals: Manufacture of kits."
15- Adrian Longstaffe, "Guidelines on the use of living animals for scientific investigations: The Animal Research and Welfare Panel of the Biological Council, 1984. London: c/o Institute of Biology, 20 Queensberry Place, London SW7 20Z. 19 pp. Price:£ 1· 50 post free (reduced price for bulk orders). ISBN 0 9500213 1 8." ed: Royal Society of Tropical Medicine and Hygiene, (1985).
16- N Sadeghzadeh, M Ahmadzadeh, and M Erfani, "Evaluation of a new radiolabeled bombesin derivative with 99mTc as potential targeted tumor imaging agent." Journal of radioanalytical and nuclear chemistry, Vol. 298 (No. 1), pp. 287-93, (2013).
17- Masoud Sadeghzadeh, Saeed Shanehsazzadeh, and Afsaneh Lahooti, "Assessment of the effective absorbed dose of 4-benzyl-1-(3-[125I]-iodobenzylsulfonyl) piperidine in humans on the basis of biodistribution data of rats." Nuclear medicine communications, Vol. 36 (No. 1), pp. 90-94, (2015).
18- Saeed Shanehsazzadeh et al., "Monoclonal antibody conjugated magnetic nanoparticles could target MUC‐1‐positive cells in vitro but not in vivo." Contrast media & molecular imaging, Vol. 10 (No. 3), pp. 225-36, (2015).
19- A Jalilian, S Shanehsazzadeh, M Akhlaghi, J Garousi, S Rajabifar, and M Tavakoli, "Preparation and biodistribution of [67 Ga]-DTPA-gonadorelin in normal rats." Journal of radioanalytical and nuclear chemistry, Vol. 278 (No. 1), pp. 123-29, (2008).
20- RB Sparks and B Aydogan, "Comparison of the effectiveness of some common animal data scaling techniques in estimating human radiation dose." Oak Ridge Associated Universities, TN (United States), (1999).
21- JM Peters and Eldon M Boyd, "Organ weights and water levels of the rat following reduced food intake." The Journal of Nutrition, Vol. 90 (No. 4), pp. 354-60, (1966).
22- JJ Bevelacqua, "Internal dosimetry primer." Radiation protection management, Vol. 22 (No. 5), p. 7, (2005).
23- WS Snyder, "" S" absorbed dose per unit cumulated activity for selected radionuclides and organs." MIRD Pamphlet no. 11, (1975).
24- Jack Valentin, "Basic anatomical and physiological data for use in radiological protection: reference values: ICRP Publication 89." Annals of the ICRP, Vol. 32 (No. 3-4), pp. 1-277, (2002).
25- ICRP, ICRP Publication 62: Radiological Protection in Biomedical Research. Elsevier Health Sciences, (1993).
26- Richard E Toohey, Michael G Stabin, and Evelyn E Watson, "The Aapm/Rsna Physics Tutorial for Residents: Internal Radiation Dosimetry: Principles and Applications 1 (Cme Available in Print Version and on Rsna Link)." Radiographics, Vol. 20 (No. 2), pp. 533-46, (2000).
27- Mathieu Charest and Chantal Asselin, "Effective dose in nuclear medicine studies and SPECT/CT: dosimetry survey across Quebec Province." Journal of nuclear medicine technology, Vol. 46 (No. 2), pp. 107-13, (2018).
28- Nadia Helal, "Patient organs dose calculations in nuclear medicine." Int J Res Rev Appl Sci, Vol. 11 (No. 1), pp. 153-61, (2012).
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| Issue | Vol 10 No 1 (2023) | |
| Section | Technical Note | |
| DOI | https://doi.org/10.18502/fbt.v10i1.11518 | |
| Keywords | ||
| Absorption Dose Biodistribution Internal Dosimetry Nuclear Medicine 99Tc-Methoxyisobutylisonitrile | ||
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