Relationship between the Patients’ Setup Errors with Dosimetric and Radiobiologic Parameters in Whole Breast Radiotherapy
-
Zahra Alijani
,
Kourosh Ebrahimnejad Gorji
,
Ali Shabestani Monfared
,
Abbas Rahimi Alisaraee
,
Ali Esmaeeli
,
Fatemeh Niksirat
Abstract
parameters for left-sided Whole-Breast Irradiation (WBI) in three different radiotherapy techniques, including Intensity-Modulated Radiation Therapy (IMRT), Field-In-Field (FIF), and Conventional Wedge (CW).
Materials and Methods: Computed Tomography (CT) images of 10 female patients with early-stage left-sided breast cancer were used to simulate different radiotherapy techniques (IMRT, FIF, and CW). The dosimetric parameters; Conformity Index (CI), Homogeneity Index (HI), the dose received by at least 95% (D95%) of Planning Tumor Volume (PTV), the volume of lung and heart that respectively received at least 20% (V20%) and 40% (V40%) of the prescribed dose, as well as, the radiobiologic parameters, including Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP) were assessed for setup errors in patients. The setup errors were assessed by shifting the isocenters and gantry angles of the treatment plans.
Results: The D95% of the PTV for an isocenter misplacement plan in the posterior direction decreased by 66.99 (IMRT), 71.86 (CW), and 68.25% (FIF). The TCP of the PTV was reduced by 26.66, 39.16, and 36.97% for IMRT, CW, and FIF techniques, respectively. Increasing gantry angle by a ±10 degree caused a 43%, 41%, and 41% decrease in the D95% of IMRT, FIF, and CW techniques, respectively. The TCP values decreased about 18% in all three techniques with a ±10 degree gantry angle shift; however, the NTCP values of the heart and lungs increased for all three methods. The CI and HI values had significantly more changes with increasing setup errors in the IMRT than in the two techniques.
Conclusion: The radiobiologic parameters in IMRT were less sensitive to setup errors compared to FIF and CW techniques. The radiobiological parameters can help estimate the setup errors along with physical parameters during breast radiotherapy.
1- T. C. Lin et al., "Automated Hypofractionated IMRT treatment planning for early-stage breast Cancer." (in eng), Radiat Oncol, Vol. 15 (No. 1), p. 67, Mar 17 (2020).
2- J. F. Calvo-Ortega, S. Moragues, M. Pozo, and J. Casals, "Dosimetric feasibility of an "off-breast isocenter" technique for whole-breast cancer radiotherapy." (in eng), Rep Pract Oncol Radiother, Vol. 21 (No. 6), pp. 500-07, Nov-Dec (2016).
3- A. Banaei, B. Hashemi, and M. Bakhshandeh, "Comparing the monoisocentric and dual isocentric techniques in chest wall radiotherapy of mastectomy patients." (in eng), J Appl Clin Med Phys, Vol. 16 (No. 1), p. 5069, Jan 8 (2015).
4- R. A. Firouzjah, A. Banaei, B. Farhood, and M. Bakhshandeh, "Dosimetric Comparison of Four Different Techniques for Supraclavicular Irradiation in 3D-conformal Radiotherapy of Breast Cancer." (in eng), Health Phys, Vol. 116 (No. 5), pp. 631-36, May (2019).
5- Saba Nadi, Razzagh Abedi-Firouzjah, Amin Banaei, Salar Bijari, and Mahdi Elahi, "Dosimetric comparison of level II lymph nodes between mono-isocentric and dual-isocentric approaches in 3D-CRT and IMRT techniques in breast radiotherapy of mastectomy patients." Journal of Radiotherapy in Practice, Vol. 19 (No. 3), pp. 254-58, (2019).
6- J. F. Yang et al., "Long-Term Breast Cancer Patient Outcomes After Adjuvant Radiotherapy Using Intensity-Modulated Radiotherapy or Conventional Tangential Radiotherapy." (in eng), Medicine (Baltimore), Vol. 95 (No. 11), p. e3113, Mar (2016).
7- Z. S. Al-Rahbi et al., "Dosimetric comparison of intensity modulated radiotherapy isocentric field plans and field in field (FIF) forward plans in the treatment of breast cancer." (in eng), J Med Phys, Vol. 38 (No. 1), pp. 22-9, Jan (2013).
8- H. Tanaka et al., "Evaluation of the field-in-field technique with lung blocks for breast tangential radiotherapy." (in eng), Nagoya J Med Sci, Vol. 77 (No. 3), pp. 339-45, Aug (2015).
9- O. Kyu Noh et al., "Probabilities of Pulmonary and Cardiac Complications and Radiographic Parameters in Breast Cancer Radiotherapy." Radiat Oncol J, Vol. 28 (No. 1), pp. 23-31, 3 (2010).
10- F. Falahati, A. Nickfarjam, and M. Shabani, "A Feasibility Study of IMRT of Lung Cancer Using Gafchromic EBT3 Film." (in en), Journal of Biomedical Physics and Engineering, Vol. 8 (No. 4), pp. 347-56, (2018).
11- F. Lohr et al., "Potential effect of robust and simple IMRT approach for left-sided breast cancer on cardiac mortality." (in eng), Int J Radiat Oncol Biol Phys, Vol. 74 (No. 1), pp. 73-80, May 1 (2009).
12- G. M. Freedman, T. Li, N. Nicolaou, Y. Chen, C. C. Ma, and P. R. Anderson, "Breast intensity-modulated radiation therapy reduces time spent with acute dermatitis for women of all breast sizes during radiation." (in eng), Int J Radiat Oncol Biol Phys, Vol. 74 (No. 3), pp. 689-94, Jul 1 (2009).
13- D. M. Guttmann et al., "Comparison of acute toxicities between contemporary forward-planned 3D conformal radiotherapy and inverse-planned intensity-modulated radiotherapy for whole breast radiation." (in eng), Breast J, Vol. 24 (No. 2), pp. 128-32, Mar (2018).
14- A. van Mourik, S. van Kranen, S. den Hollander, J. J. Sonke, M. van Herk, and C. van Vliet-Vroegindeweij, "Effects of setup errors and shape changes on breast radiotherapy." (in eng), Int J Radiat Oncol Biol Phys, Vol. 79 (No. 5), pp. 1557-64, Apr 1 (2011).
15- P. Sakyanun, K. Saksornchai, C. Nantavithya, C. Chakkabat, and K. Shotelersuk, "The effect of deep inspiration breath-hold technique on left anterior descending coronary artery and heart dose in left breast irradiation." (in eng), Radiat Oncol J, Vol. 38 (No. 3), pp. 181-88, Sep (2020).
16- (!!! INVALID CITATION !!! (16)).
17- G. Gagliardi et al., "Radiation pneumonitis after breast cancer irradiation: analysis of the complication probability using the relative seriality model." (in eng), Int J Radiat Oncol Biol Phys, Vol. 46 (No. 2), pp. 373-81, Jan 15 (2000).
18- S. R. Lee, M. J. Kim, S. H. Park, M. Y. Lee, and T. S. Suh, "Radiobiological and physical effects of patient setup errors during whole breast irradiation." Int-J-Radiat-Res, Vol. 15 (No. 4), pp. 343-52, (2017).
19- Sunmin Park, Chai Hong Rim, and Won Sup Yoon, "Variation of heart and lung radiation doses according to setup uncertainty in left breast cancer." Radiation Oncology, Vol. 16 (No. 1), p. 78, 2021/04/20 (2021).
20- S. Chopra, K. A. Dinshaw, R. Kamble, and R. Sarin, "Breast movement during normal and deep breathing, respiratory training and set up errors: implications for external beam partial breast irradiation." (in eng), Br J Radiol, Vol. 79 (No. 945), pp. 766-73, Sep (2006).
21- J. Chavaudra and A. Bridier, "[Definition of volumes in external radiotherapy: ICRU reports 50 and 62]." (in fre), Cancer Radiother, Vol. 5 (No. 5), pp. 472-8, Oct (2001). Définition des volumes en radiothérapie externe: rapports ICRU 50 et 62.
22- I. Dayes, R. B. Rumble, J. Bowen, P. Dixon, and P. Warde, "Intensity-modulated radiotherapy in the treatment of breast cancer." (in eng), Clin Oncol (R Coll Radiol), Vol. 24 (No. 7), pp. 488-98, Sep (2012).
23- A. Harsolia et al., "Intensity-modulated radiotherapy results in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapy." (in eng), Int J Radiat Oncol Biol Phys, Vol. 68 (No. 5), pp. 1375-80, Aug 1 (2007).
24- G. N. Marta, S. A. Hanna, and R. Gadia, "Treatment with intensity-modulated radiation therapy (IMRT) for breast cancer." (in eng), Rev Assoc Med Bras (1992), Vol. 60 (No. 6), pp. 508-11, Nov-Dec (2014).
25- R. Kinoshita et al., "Three-dimensional intrafractional motion of breast during tangential breast irradiation monitored with high-sampling frequency using a real-time tumor-tracking radiotherapy system." (in eng), Int J Radiat Oncol Biol Phys, Vol. 70 (No. 3), pp. 931-4, Mar 1 (2008).
26- Q. Wu, R. Mohan, M. Morris, A. Lauve, and R. Schmidt-Ullrich, "Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas. I: dosimetric results." (in eng), Int J Radiat Oncol Biol Phys, Vol. 56 (No. 2), pp. 573-85, Jun 1 (2003).
27- D. Petrova, S. Smickovska, and E. Lazarevska, "Conformity Index and Homogeneity Index of the Postoperative Whole Breast Radiotherapy." (in eng), Open Access Maced J Med Sci, Vol. 5 (No. 6), pp. 736-39, Oct 15 (2017).
28- G. Luxton, P. J. Keall, and C. R. King, "A new formula for normal tissue complication probability (NTCP) as a function of equivalent uniform dose (EUD)." (in eng), Phys Med Biol, Vol. 53 (No. 1), pp. 23-36, Jan 7 (2008).
29- Yusung Kim and Wolfgang A. Tomé, "Optimization of Radiotherapy Using Biological Parameters." in Radiation Oncology Advances, Søren M. Bentzen, Paul M. Harari, Wolfgang A. Tomé, and Minesh P. Mehta, Eds. Boston, MA: Springer US, (2008), pp. 253-74.
30- J. Y. Park et al., "Radiobiological model-based bio-anatomical quality assurance in intensity-modulated radiation therapy for prostate cancer." (in eng), J Radiat Res, Vol. 53 (No. 6), pp. 978-88, Nov 1 (2012).
31- M. Guerrero and X. A. Li, "Analysis of a large number of clinical studies for breast cancer radiotherapy: estimation of radiobiological parameters for treatment planning." (in eng), Phys Med Biol, Vol. 48 (No. 20), pp. 3307-26, Oct 21 (2003).
32- J. Willner, K. Baier, E. Caragiani, A. Tschammler, and M. Flentje, "Dose, volume, and tumor control prediction in primary radiotherapy of non-small-cell lung cancer." (in eng), Int J Radiat Oncol Biol Phys, Vol. 52 (No. 2), pp. 382-9, Feb 1 (2002).
33- B. Emami et al., "Tolerance of normal tissue to therapeutic irradiation." (in eng), Int J Radiat Oncol Biol Phys, Vol. 21 (No. 1), pp. 109-22, May 15 (1991).
34- J. C. Stroom and B. J. Heijmen, "Geometrical uncertainties, radiotherapy planning margins, and the ICRU-62 report." (in eng), Radiother Oncol, Vol. 64 (No. 1), pp. 75-83, Jul (2002).
35- A. Niemierko and M. Goitein, "Implementation of a model for estimating tumor control probability for an inhomogeneously irradiated tumor." (in eng), Radiother Oncol, Vol. 29 (No. 2), pp. 140-7, Nov (1993).
36- H. A. Gay and A. Niemierko, "A free program for calculating EUD-based NTCP and TCP in external beam radiotherapy." (in eng), Phys Med, Vol. 23 (No. 3-4), pp. 115-25, Dec (2007).
37- S. C. Darby et al., "Risk of ischemic heart disease in women after radiotherapy for breast cancer." (in eng), N Engl J Med, Vol. 368 (No. 11), pp. 987-98, Mar 14 (2013).
38- C. W. Taylor et al., "Cardiac dose from tangential breast cancer radiotherapy in the year 2006." (in eng), Int J Radiat Oncol Biol Phys, Vol. 72 (No. 2), pp. 501-7, Oct 1 (2008).
39- T. F. Lee, F. M. Fang, P. J. Chao, T. J. Su, L. K. Wang, and S. W. Leung, "Dosimetric comparisons of helical tomotherapy and step-and-shoot intensity-modulated radiotherapy in nasopharyngeal carcinoma." (in eng), Radiother Oncol, Vol. 89 (No. 1), pp. 89-96, Oct (2008).
40- E. L. Lorenzen, C. Brink, C. W. Taylor, S. C. Darby, and M. Ewertz, "Uncertainties in estimating heart doses from 2D-tangential breast cancer radiotherapy." (in eng), Radiother Oncol, Vol. 119 (No. 1), pp. 71-6, Apr (2016).
41- V. Batumalai, L. Holloway, and G. P. Delaney, "A review of setup error in supine breast radiotherapy using cone-beam computed tomography." (in eng), Med Dosim, Vol. 41 (No. 3), pp. 225-9, Autumn (2016).
42- R. Prabhakar et al., "Simulation of dose to surrounding normal structures in tangential breast radiotherapy due to setup error." (in eng), Med Dosim, Vol. 33 (No. 1), pp. 81-5, Spring (2008).
43- T. Furuya, S. Sugimoto, C. Kurokawa, S. Ozawa, K. Karasawa, and K. Sasai, "The dosimetric impact of respiratory breast movement and daily setup error on tangential whole breast irradiation using conventional wedge, field-in-field and irregular surface compensator techniques." (in eng), J Radiat Res, Vol. 54 (No. 1), pp. 157-65, Jan (2013).
44- U. Nastasi, Laura Gianusso, Francesca De Monte, Alessandra Cannizzaro, and Paolo Rovea, "Clinical implementation of IMRT step and shoot with simultaneous integrated boost for breast cancer: A dosimetric comparison of planning techniques." International Journal of Cancer Therapy and Oncology, Vol. 5(2017).
45- A. K. Bhatnagar et al., "Intensity modulated radiation therapy (IMRT) reduces the dose to the contralateral breast when compared to conventional tangential fields for primary breast irradiation." (in eng), Breast Cancer Res Treat, Vol. 96 (No. 1), pp. 41-6, Mar (2006).
46- H. B. Ayata, M. Güden, C. Ceylan, N. Kücük, and K. Engin, "Comparison of dose distributions and organs at risk (OAR) doses in conventional tangential technique (CTT) and IMRT plans with different numbers of beam in left-sided breast cancer." (in eng), Rep Pract Oncol Radiother, Vol. 16 (No. 3), pp. 95-102, (2011).
2- J. F. Calvo-Ortega, S. Moragues, M. Pozo, and J. Casals, "Dosimetric feasibility of an "off-breast isocenter" technique for whole-breast cancer radiotherapy." (in eng), Rep Pract Oncol Radiother, Vol. 21 (No. 6), pp. 500-07, Nov-Dec (2016).
3- A. Banaei, B. Hashemi, and M. Bakhshandeh, "Comparing the monoisocentric and dual isocentric techniques in chest wall radiotherapy of mastectomy patients." (in eng), J Appl Clin Med Phys, Vol. 16 (No. 1), p. 5069, Jan 8 (2015).
4- R. A. Firouzjah, A. Banaei, B. Farhood, and M. Bakhshandeh, "Dosimetric Comparison of Four Different Techniques for Supraclavicular Irradiation in 3D-conformal Radiotherapy of Breast Cancer." (in eng), Health Phys, Vol. 116 (No. 5), pp. 631-36, May (2019).
5- Saba Nadi, Razzagh Abedi-Firouzjah, Amin Banaei, Salar Bijari, and Mahdi Elahi, "Dosimetric comparison of level II lymph nodes between mono-isocentric and dual-isocentric approaches in 3D-CRT and IMRT techniques in breast radiotherapy of mastectomy patients." Journal of Radiotherapy in Practice, Vol. 19 (No. 3), pp. 254-58, (2019).
6- J. F. Yang et al., "Long-Term Breast Cancer Patient Outcomes After Adjuvant Radiotherapy Using Intensity-Modulated Radiotherapy or Conventional Tangential Radiotherapy." (in eng), Medicine (Baltimore), Vol. 95 (No. 11), p. e3113, Mar (2016).
7- Z. S. Al-Rahbi et al., "Dosimetric comparison of intensity modulated radiotherapy isocentric field plans and field in field (FIF) forward plans in the treatment of breast cancer." (in eng), J Med Phys, Vol. 38 (No. 1), pp. 22-9, Jan (2013).
8- H. Tanaka et al., "Evaluation of the field-in-field technique with lung blocks for breast tangential radiotherapy." (in eng), Nagoya J Med Sci, Vol. 77 (No. 3), pp. 339-45, Aug (2015).
9- O. Kyu Noh et al., "Probabilities of Pulmonary and Cardiac Complications and Radiographic Parameters in Breast Cancer Radiotherapy." Radiat Oncol J, Vol. 28 (No. 1), pp. 23-31, 3 (2010).
10- F. Falahati, A. Nickfarjam, and M. Shabani, "A Feasibility Study of IMRT of Lung Cancer Using Gafchromic EBT3 Film." (in en), Journal of Biomedical Physics and Engineering, Vol. 8 (No. 4), pp. 347-56, (2018).
11- F. Lohr et al., "Potential effect of robust and simple IMRT approach for left-sided breast cancer on cardiac mortality." (in eng), Int J Radiat Oncol Biol Phys, Vol. 74 (No. 1), pp. 73-80, May 1 (2009).
12- G. M. Freedman, T. Li, N. Nicolaou, Y. Chen, C. C. Ma, and P. R. Anderson, "Breast intensity-modulated radiation therapy reduces time spent with acute dermatitis for women of all breast sizes during radiation." (in eng), Int J Radiat Oncol Biol Phys, Vol. 74 (No. 3), pp. 689-94, Jul 1 (2009).
13- D. M. Guttmann et al., "Comparison of acute toxicities between contemporary forward-planned 3D conformal radiotherapy and inverse-planned intensity-modulated radiotherapy for whole breast radiation." (in eng), Breast J, Vol. 24 (No. 2), pp. 128-32, Mar (2018).
14- A. van Mourik, S. van Kranen, S. den Hollander, J. J. Sonke, M. van Herk, and C. van Vliet-Vroegindeweij, "Effects of setup errors and shape changes on breast radiotherapy." (in eng), Int J Radiat Oncol Biol Phys, Vol. 79 (No. 5), pp. 1557-64, Apr 1 (2011).
15- P. Sakyanun, K. Saksornchai, C. Nantavithya, C. Chakkabat, and K. Shotelersuk, "The effect of deep inspiration breath-hold technique on left anterior descending coronary artery and heart dose in left breast irradiation." (in eng), Radiat Oncol J, Vol. 38 (No. 3), pp. 181-88, Sep (2020).
16- (!!! INVALID CITATION !!! (16)).
17- G. Gagliardi et al., "Radiation pneumonitis after breast cancer irradiation: analysis of the complication probability using the relative seriality model." (in eng), Int J Radiat Oncol Biol Phys, Vol. 46 (No. 2), pp. 373-81, Jan 15 (2000).
18- S. R. Lee, M. J. Kim, S. H. Park, M. Y. Lee, and T. S. Suh, "Radiobiological and physical effects of patient setup errors during whole breast irradiation." Int-J-Radiat-Res, Vol. 15 (No. 4), pp. 343-52, (2017).
19- Sunmin Park, Chai Hong Rim, and Won Sup Yoon, "Variation of heart and lung radiation doses according to setup uncertainty in left breast cancer." Radiation Oncology, Vol. 16 (No. 1), p. 78, 2021/04/20 (2021).
20- S. Chopra, K. A. Dinshaw, R. Kamble, and R. Sarin, "Breast movement during normal and deep breathing, respiratory training and set up errors: implications for external beam partial breast irradiation." (in eng), Br J Radiol, Vol. 79 (No. 945), pp. 766-73, Sep (2006).
21- J. Chavaudra and A. Bridier, "[Definition of volumes in external radiotherapy: ICRU reports 50 and 62]." (in fre), Cancer Radiother, Vol. 5 (No. 5), pp. 472-8, Oct (2001). Définition des volumes en radiothérapie externe: rapports ICRU 50 et 62.
22- I. Dayes, R. B. Rumble, J. Bowen, P. Dixon, and P. Warde, "Intensity-modulated radiotherapy in the treatment of breast cancer." (in eng), Clin Oncol (R Coll Radiol), Vol. 24 (No. 7), pp. 488-98, Sep (2012).
23- A. Harsolia et al., "Intensity-modulated radiotherapy results in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapy." (in eng), Int J Radiat Oncol Biol Phys, Vol. 68 (No. 5), pp. 1375-80, Aug 1 (2007).
24- G. N. Marta, S. A. Hanna, and R. Gadia, "Treatment with intensity-modulated radiation therapy (IMRT) for breast cancer." (in eng), Rev Assoc Med Bras (1992), Vol. 60 (No. 6), pp. 508-11, Nov-Dec (2014).
25- R. Kinoshita et al., "Three-dimensional intrafractional motion of breast during tangential breast irradiation monitored with high-sampling frequency using a real-time tumor-tracking radiotherapy system." (in eng), Int J Radiat Oncol Biol Phys, Vol. 70 (No. 3), pp. 931-4, Mar 1 (2008).
26- Q. Wu, R. Mohan, M. Morris, A. Lauve, and R. Schmidt-Ullrich, "Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas. I: dosimetric results." (in eng), Int J Radiat Oncol Biol Phys, Vol. 56 (No. 2), pp. 573-85, Jun 1 (2003).
27- D. Petrova, S. Smickovska, and E. Lazarevska, "Conformity Index and Homogeneity Index of the Postoperative Whole Breast Radiotherapy." (in eng), Open Access Maced J Med Sci, Vol. 5 (No. 6), pp. 736-39, Oct 15 (2017).
28- G. Luxton, P. J. Keall, and C. R. King, "A new formula for normal tissue complication probability (NTCP) as a function of equivalent uniform dose (EUD)." (in eng), Phys Med Biol, Vol. 53 (No. 1), pp. 23-36, Jan 7 (2008).
29- Yusung Kim and Wolfgang A. Tomé, "Optimization of Radiotherapy Using Biological Parameters." in Radiation Oncology Advances, Søren M. Bentzen, Paul M. Harari, Wolfgang A. Tomé, and Minesh P. Mehta, Eds. Boston, MA: Springer US, (2008), pp. 253-74.
30- J. Y. Park et al., "Radiobiological model-based bio-anatomical quality assurance in intensity-modulated radiation therapy for prostate cancer." (in eng), J Radiat Res, Vol. 53 (No. 6), pp. 978-88, Nov 1 (2012).
31- M. Guerrero and X. A. Li, "Analysis of a large number of clinical studies for breast cancer radiotherapy: estimation of radiobiological parameters for treatment planning." (in eng), Phys Med Biol, Vol. 48 (No. 20), pp. 3307-26, Oct 21 (2003).
32- J. Willner, K. Baier, E. Caragiani, A. Tschammler, and M. Flentje, "Dose, volume, and tumor control prediction in primary radiotherapy of non-small-cell lung cancer." (in eng), Int J Radiat Oncol Biol Phys, Vol. 52 (No. 2), pp. 382-9, Feb 1 (2002).
33- B. Emami et al., "Tolerance of normal tissue to therapeutic irradiation." (in eng), Int J Radiat Oncol Biol Phys, Vol. 21 (No. 1), pp. 109-22, May 15 (1991).
34- J. C. Stroom and B. J. Heijmen, "Geometrical uncertainties, radiotherapy planning margins, and the ICRU-62 report." (in eng), Radiother Oncol, Vol. 64 (No. 1), pp. 75-83, Jul (2002).
35- A. Niemierko and M. Goitein, "Implementation of a model for estimating tumor control probability for an inhomogeneously irradiated tumor." (in eng), Radiother Oncol, Vol. 29 (No. 2), pp. 140-7, Nov (1993).
36- H. A. Gay and A. Niemierko, "A free program for calculating EUD-based NTCP and TCP in external beam radiotherapy." (in eng), Phys Med, Vol. 23 (No. 3-4), pp. 115-25, Dec (2007).
37- S. C. Darby et al., "Risk of ischemic heart disease in women after radiotherapy for breast cancer." (in eng), N Engl J Med, Vol. 368 (No. 11), pp. 987-98, Mar 14 (2013).
38- C. W. Taylor et al., "Cardiac dose from tangential breast cancer radiotherapy in the year 2006." (in eng), Int J Radiat Oncol Biol Phys, Vol. 72 (No. 2), pp. 501-7, Oct 1 (2008).
39- T. F. Lee, F. M. Fang, P. J. Chao, T. J. Su, L. K. Wang, and S. W. Leung, "Dosimetric comparisons of helical tomotherapy and step-and-shoot intensity-modulated radiotherapy in nasopharyngeal carcinoma." (in eng), Radiother Oncol, Vol. 89 (No. 1), pp. 89-96, Oct (2008).
40- E. L. Lorenzen, C. Brink, C. W. Taylor, S. C. Darby, and M. Ewertz, "Uncertainties in estimating heart doses from 2D-tangential breast cancer radiotherapy." (in eng), Radiother Oncol, Vol. 119 (No. 1), pp. 71-6, Apr (2016).
41- V. Batumalai, L. Holloway, and G. P. Delaney, "A review of setup error in supine breast radiotherapy using cone-beam computed tomography." (in eng), Med Dosim, Vol. 41 (No. 3), pp. 225-9, Autumn (2016).
42- R. Prabhakar et al., "Simulation of dose to surrounding normal structures in tangential breast radiotherapy due to setup error." (in eng), Med Dosim, Vol. 33 (No. 1), pp. 81-5, Spring (2008).
43- T. Furuya, S. Sugimoto, C. Kurokawa, S. Ozawa, K. Karasawa, and K. Sasai, "The dosimetric impact of respiratory breast movement and daily setup error on tangential whole breast irradiation using conventional wedge, field-in-field and irregular surface compensator techniques." (in eng), J Radiat Res, Vol. 54 (No. 1), pp. 157-65, Jan (2013).
44- U. Nastasi, Laura Gianusso, Francesca De Monte, Alessandra Cannizzaro, and Paolo Rovea, "Clinical implementation of IMRT step and shoot with simultaneous integrated boost for breast cancer: A dosimetric comparison of planning techniques." International Journal of Cancer Therapy and Oncology, Vol. 5(2017).
45- A. K. Bhatnagar et al., "Intensity modulated radiation therapy (IMRT) reduces the dose to the contralateral breast when compared to conventional tangential fields for primary breast irradiation." (in eng), Breast Cancer Res Treat, Vol. 96 (No. 1), pp. 41-6, Mar (2006).
46- H. B. Ayata, M. Güden, C. Ceylan, N. Kücük, and K. Engin, "Comparison of dose distributions and organs at risk (OAR) doses in conventional tangential technique (CTT) and IMRT plans with different numbers of beam in left-sided breast cancer." (in eng), Rep Pract Oncol Radiother, Vol. 16 (No. 3), pp. 95-102, (2011).
| Files | ||
| Issue | Vol 10 No 3 (2023) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/fbt.v10i3.13155 | |
| Keywords | ||
| Whole Breast Radiotherapy Setup Errors Intensity-Modulated Radiation Therapy Field-In-Field Radiobiological Parameters | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Alijani Z, Ebrahimnejad Gorji K, Shabestani Monfared A, Rahimi Alisaraee A, Esmaeeli A, Niksirat F. Relationship between the Patients’ Setup Errors with Dosimetric and Radiobiologic Parameters in Whole Breast Radiotherapy. Frontiers Biomed Technol. 2023;10(3):268-276.
