Original Article

Efficacy of 153Sm-EDTMP on Bone Pain Palliation in Metastatic Patients: Breast and Prostate Cancers

Abstract

Purpose: This study aimed to evaluate the effect of samarium-153-EDTMP (153Sm-EDTMP) on pain relief bone metastases of Breast Cancer (BC) and Prostate Cancer (PC) patients.

Materials and Methods: Thirty patients aged 40-77 years (62.6±10.2 years) with intractable metastatic bone pain were included in the current study. A checklist of patient information and a standard questionnaire for the assessment of pain and quality of life were completed before and after four and eight week’s palliative treatment with 37 MBq/kg of 153Sm-EDTMP. To analyse the data, parametric and non-parametric tests were used in SPSS software.

Results: Twelve females with BC (40%) and 18 males with PC (60%) were included. Four and eight weeks after palliative treatment of 153Sm-EDTMP, the mean pain score reduction and quality of life were statistically increased compared to before the intervention (P-value < 0.05). Notably, the amount of pain reduction in the fourth week was more than in the eighth week; however, the quality of life was better in the eighth week, without significant variation (P-value <0.05). In addition, there was no statistically significant relationship between pain reduction and the type of primary diseases, BC, and PC (P-value >0.05).

Conclusion: The injection of 153Sm-EDTMP had therapeutic efficacy for bone pain palliation in patients with diffuse bone metastases at the end of the 4th and 8th week post-infusion.

1- R. E. Coleman et al., "Bone metastases." (in eng), Nat Rev Dis Primers, Vol. 6 (No. 1), p. 83, Oct 15 (2020).
2- R. McDonald et al., "Quality of life after palliative radiotherapy in bone metastases: A literature review." (in eng), J Bone Oncol, Vol. 4 (No. 1), pp. 24-31, Mar (2015).
3- P. G. Westhoff et al., "Quality of Life in Relation to Pain Response to Radiation Therapy for Painful Bone Metastases." (in eng), Int J Radiat Oncol Biol Phys, Vol. 93 (No. 3), pp. 694-701, Nov 1 (2015).
4- C. De la Pinta, "SBRT in non-spine bone metastases: a literature review." (in eng), Med Oncol, Vol. 37 (No. 12), p. 119, Nov 21 (2020).
5- F. M. Y. Lim, A. Bobrowski, A. Agarwal, and M. F. Silva, "Use of corticosteroids for pain control in cancer patients with bone metastases: a comprehensive literature review." (in eng), Curr Opin Support Palliat Care, Vol. 11 (No. 2), pp. 78-87, Jun (2017).
6- A. W. Smith, B. A. Greenberger, R. B. Den, and R. G. Stock, "Radiopharmaceuticals for Bone Metastases." (in eng), Semin Radiat Oncol, Vol. 31 (No. 1), pp. 45-59, Jan (2021).
7- SHOMOKH Alsharef, MASHAEL Alanazi, FATIMAH Alharthi, DANA Qandil, and MONA Qushawy, "Review about radiopharmaceuticals: preparation, radioactivity, and applications." Int J App Pharm, Vol. 12 (No. 3), pp. 8-15, (2020).
8- J. M. Jong et al., "Radiopharmaceuticals for Palliation of Bone Pain in Patients with Castration-resistant Prostate Cancer Metastatic to Bone: A Systematic Review." (in eng), Eur Urol, Vol. 70 (No. 3), pp. 416-26, Sep (2016).
9- M. Alavi et al., "(177)Lu/(153)Sm-Ethylenediamine Tetramethylene Phosphonic Acid Cocktail: A Novel Palliative Treatment for Patients with Bone Metastases." (in eng), Cancer Biother Radiopharm, Vol. 34 (No. 5), pp. 280-87, Jun (2019).
10- M. Taheri et al., "153Sm-EDTMP and 177Lu-EDTMP are equally safe and effective in pain palliation from skeletal metastases." (in eng), Nuklearmedizin, Vol. 57 (No. 5), pp. 174-80, Sep (2018). 153Sm-EDTMP und 177Lu-EDTMP sind gleichermaßen sicher und wirksam bei der Schmerzlinderung von Skelettmetastasen - Eine randomisierte, doppelblinde klinische Studie.
11- Farhad Ghadiri, Peiman Haddad, Jahangir Mehdifar, and Hojjat Zeraati, "Evaluation of Strontium-89 in palliative treatment of widespread and painful bone metastases due to breast and prostate cancer [Persian]." Iranian Journal of Nuclear Medicine, Vol. 8 (No. 1), pp. 54-61, (2000).
12- J. H. Turner et al., "Samarium-153 EDTMP therapy of disseminated skeletal metastasis." (in eng), Eur J Nucl Med, Vol. 15 (No. 12), pp. 784-95, (1989).
13- HELMUT SINZINGER, KONRAD WEISS, and JUKKA HILTUNEN, "Background, Reasons and Benefits Using the Vienna Protocol for the Treatment of Painful Bone Recurrences with 153Samarium-EDTMP." Anticancer Research, Vol. 29 (No. 8), pp. 3393-95, (2009).
14- X. Zhang, N. Li, Y. Zhu, and W. Wen, "The role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma." (in eng), Cancer Med, Vol. 11 (No. 4), pp. 931-43, Feb (2022).
15- S. Sharma, B. Singh, A. Koul, and B. R. Mittal, "Comparative Therapeutic Efficacy of (153)Sm-EDTMP and (177)Lu-EDTMP for Bone Pain Palliation in Patients with Skeletal Metastases: Patients' Pain Score Analysis and Personalized Dosimetry." (in eng), Front Med (Lausanne), Vol. 4p. 46, (2017).
16- H. Kolesnikov-Gauthier, N. Lemoine, E. Tresch-Bruneel, A. Olivier, A. Oudoux, and N. Penel, "Efficacy and safety of (153)Sm-EDTMP as treatment of painful bone metastasis: a large single-center study." (in eng), Support Care Cancer, Vol. 26 (No. 3), pp. 751-58, Mar (2018).
17- J. Dolezal, "Efficacy and toxicity of 153samarium-EDTMP in painful breast cancer bone metastases." (in eng), Onkologie, Vol. 32 (No. 1-2), pp. 35-9, Feb (2009).
18- Davood Beiki et al., "Effectiveness and complications of 153Sm-EDTMP in palliative treatment of diffuse skeletal metastases." Iranian Journal of Nuclear Medicine, Vol. 21 (No. 1), pp. 26-32, (2013).
19- S. Ricci et al., "Clinical benefit of bone-targeted radiometabolic therapy with 153Sm-EDTMP combined with chemotherapy in patients with metastatic hormone-refractory prostate cancer." (in eng), Eur J Nucl Med Mol Imaging, Vol. 34 (No. 7), pp. 1023-30, Jul (2007).
20- L. Vigna et al., "Characterization of the [(153)Sm]Sm-EDTMP pharmacokinetics and estimation of radiation absorbed dose on an individual basis." (in eng), Phys Med, Vol. 27 (No. 3), pp. 144-52, Jul (2011).
Files
IssueVol 10 No 3 (2023) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/fbt.v10i3.13161
Keywords
Breast Cancer Prostate Cancer Bone Metastasis 153 Samarium Ethylenediamine Tetra (Methylene Phosphonic Acid)
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Rokni M, Amiri M, Ebrahimnejad Gorji K, Talebian H, Bijani A, Vakili M, Shafiei H, Niksirat F, Khosravi M, Shabestani Monfared A. Efficacy of 153Sm-EDTMP on Bone Pain Palliation in Metastatic Patients: Breast and Prostate Cancers. Frontiers Biomed Technol. 2023;10(3):321-326.