Original Article

Implementation of Improved U-Net and Optimized XGBoost-SVM Classifier for Early Detection of Masses and Microcalcifications in Breast

Abstract

Purpose: In contemporary time, breast cancer has been extensively found among women at a global rate of 24.2% as of 2018. This exposes the significant and imperative need for detecting masses and micro calcifications in the breast to avoid death rates. The existing histopathological images have gained a golden standard considering they would afford reliable results. However, these images have been entangled with various complexities including insufficient image contrast, noise, and misdiagnosis. These pitfalls might negatively impact the detection rate for which automatic recognition has become vital. With the momentous evolvement of Machine Learning (ML) and Deep Learning (DL), various researchers have endeavoured to consider ML and DL for accomplishing this prediction. However, they need to improve in accuracy rate due to ineffective feature extraction, and most studies averted to consider segmentation. Hence, this study regards accomplishing a high classification and segmentation process.

Materials and Methods: The study proposes Modified Weight Updated Convolutional Block-U-Net (MWu-Conv-U-Net) to handle the image dimensions optimally. In this case, U-Net based model is regarded by improvising it with the inclusion of an additional convolutional layer in individual encoder-decoder. Further, the study proposes an Optimized Weight Updated eXtreme Gradient Boosting-Support Vector Machine (OWu-XGBoost-SVM) for determining the optimal gradient, which would eventually enhance the prediction rate.

Results: The overall performance is assessed through performance metrics to confirm its effectiveness in classifying and segmenting the Breast Cancer Histopathological (BACH) image dataset. Comparison is undertaken with conventional systems in accordance with metrics (recall, F1-score, precision, and accuracy). The results revealed the efficacy of the proposed system with 99% accuracy, 99% F1-score, 99% precision, and 99% recall.

Conclusion: High accuracy procured through the analysis reveals its efficacy and hence it could be applicable for real-time execution for assisting medical experts in early breast cancer prognosis.

1- Carlos H Barrios, "Global challenges in breast cancer detection and treatment." The Breast, Vol. 62, pp. S3-S6, (2022).
2- Mohammad Reza Abbasniya, Sayed Ali Sheikholeslamzadeh, Hamid Nasiri, and Samaneh Emami, "Classification of breast tumors based on histopathology images using deep features and ensemble of gradient boosting methods." Computers and Electrical Engineering, Vol. 103, p. 108382, (2022).
3- Haobang Liang, Jiao Li, Hejun Wu, Li Li, Xinrui Zhou, and Xinhua Jiang, "Mammographic Classification of Breast Cancer Microcalcifications through Extreme Gradient Boosting." Electronics, Vol. 11 (No. 15), p. 2435, (2022).
4- Md Zahangir Alom, Chris Yakopcic, Mst Nasrin, Tarek M Taha, and Vijayan K Asari, "Breast cancer classification from histopathological images with inception recurrent residual convolutional neural network." Journal of digital imaging, Vol. 32 (No. 4), pp. 605-17, (2019).
5- Kevin Faust et al., "Visualizing histopathologic deep learning classification and anomaly detection using nonlinear feature space dimensionality reduction." BMC bioinformatics, Vol. 19 (No. 1), pp. 1-15, (2018).
6- Yutong Zhong, Yan Piao, and Guohui Zhang, "Dilated and soft attention‐guided convolutional neural network for breast cancer histology images classification." Microscopy Research and Technique, Vol. 85 (No. 4), pp. 1248-57, (2022).
7- Laith Alzubaidi, Omran Al-Shamma, Mohammed A Fadhel, Laith Farhan, Jinglan Zhang, and Ye Duan, "Optimizing the performance of breast cancer classification by employing the same domain transfer learning from hybrid deep convolutional neural network model." Electronics, Vol. 9 (No. 3), p. 445, (2020).
8- Amira Mofreh Ibraheem, Kamel Hussein Rahouma, and Hesham FA Hamed, "3PCNNB-Net: Three Parallel CNN Branches for Breast Cancer Classification Through Histopathological Images." Journal of Medical and Biological Engineering, Vol. 41 (No. 4), pp. 494-503, (2021).
9- Sonia Mejbri, Camille Franchet, Reshma Ismat-Ara, Josiane Mothe, Pierre Brousset, and Emmanuel Faure, "Deep Analysis of CNN Settings for New Cancer whole-slide Histological Images Segmentation: the Case of Small Training Sets."
10- Kamyar Nazeri, Azad Aminpour, and Mehran Ebrahimi, "Two-Stage Convolutional Neural Network for Breast Cancer Histology Image Classification."
11- Sushovan Chaudhury, Manik Rakhra, Naz Memon, Kartik Sau, and Melkamu Teshome Ayana, "Breast cancer calcifications: identification using a novel segmentation approach." Computational and Mathematical Methods in Medicine, Vol. 2021(2021).
12- Guilherme Aresta et al., "Bach: Grand challenge on breast cancer histology images." Medical image analysis, Vol. 56, pp. 122-39, (2019).
13- Chuang Zhu, Fangzhou Song, Ying Wang, Huihui Dong, Yao Guo, and Jun Liu, "Breast cancer histopathology image classification through assembling multiple compact CNNs." BMC medical informatics and decision making, Vol. 19 (No. 1), pp. 1-17, (2019).
14- Lei Su, Yu Liu, Minghui Wang, and Ao Li, "Semi-HIC: A novel semi-supervised deep learning method for histopathological image classification." Computers in Biology and Medicine, Vol. 137p. 104788, (2021).
15- Rui Yan et al., "Breast cancer histopathological image classification using a hybrid deep neural network." Methods, Vol. 173, pp. 52-60, (2020).
16- Zhanbo Yang, Lingyan Ran, Shizhou Zhang, Yong Xia, and Yanning Zhang, "EMS-Net: Ensemble of multiscale convolutional neural networks for classification of breast cancer histology images." Neurocomputing, Vol. 366, pp. 46-53, (2019).
17- Said Boumaraf et al., "Conventional machine learning versus deep learning for magnification dependent histopathological breast cancer image classification: A comparative study with visual explanation." Diagnostics, Vol. 11 (No. 3), p. 528, (2021).
18- Rangan Das, Utsav Bandyopadhyay Maulik, Bikram Boote, Sagnik Sen, and Saumik Bhattacharya, "Multi-path Convolutional Neural Network to identify Tumorous Sub-classes for Breast Tissue from Histopathological Images." SN Computer Science, Vol. 3 (No. 5), pp. 1-11, (2022).
19- Zabit Hameed, Begonya Garcia-Zapirain, José Javier Aguirre, and Mario Arturo Isaza-Ruget, "Multiclass classification of breast cancer histopathology images using multilevel features of deep convolutional neural network." Scientific Reports, Vol. 12 (No. 1), pp. 1-21, (2022).
20- Arnab Bagchi, Payel Pramanik, and Ram Sarkar, "A Multi-Stage Approach to Breast Cancer Classification Using Histopathology Images." Available at SSRN 4065219.
21- O Ghoneim, G Soliman, A Galal, and H Mahgoub, "Breast cancer histological image classification using ensemble convolutional neural network and triplet loss." IOSR J. Comput. Eng. Ser II II, pp. 30-42, (2021).
22- Nadia Brancati, Maria Frucci, and Daniel Riccio, "Multi-classification of breast cancer histology images by using a fine-tuning strategy."
23- Taimoor Shakeel Sheikh, Yonghee Lee, and Migyung Cho, "Histopathological classification of breast cancer images using a multi-scale input and multi-feature network." Cancers, Vol. 12 (No. 8), p. 2031, (2020).
24- Chiranjibi Sitaula and Sunil Aryal, "Fusion of whole and part features for the classification of histopathological image of breast tissue." Health Information Science and Systems, Vol. 8 (No. 1), pp. 1-12, (2020).
25- Zakaria Senousy et al., "MCUa: Multi-level context and uncertainty aware dynamic deep ensemble for breast cancer histology image classification." IEEE Transactions on Biomedical Engineering, Vol. 69 (No. 2), pp. 818-29, (2021).
26- Salman Ahmed, Maria Tariq, and Hammad Naveed, "Pmnet: A probability map based scaled network for breast cancer diagnosis." Computerized Medical Imaging and Graphics, Vol. 89, p. 101863, (2021).
27- Rüdiger Schmitz et al., "Multi-scale fully convolutional neural networks for histopathology image segmentation: from nuclear aberrations to the global tissue architecture." Medical image analysis, Vol. 70, p. 101996, (2021).
28- A Relea et al., "Usefulness of the twinkling artifact on Doppler ultrasound for the detection of breast microcalcifications." Radiología (English Edition), Vol. 60 (No. 5), pp. 413-23, (2018).
29- Xi Lu and Xuedong Zhu, "Automatic segmentation of breast cancer histological images based on dual-path feature extraction network." Mathematical Biosciences and Engineering, Vol. 19 (No. 11), pp. 11137-53, (2022).
30- Haili Ye, Da-Han Wang, Jianmin Li, Shunzhi Zhu, and Chenyan Zhu, "Improving Histopathological Image Segmentation and Classification Using Graph Convolution Network."
31- Dario Sitnik and Ivica Kopriva, "LEFM-Nets: Learnable Explicit Feature Map Deep Networks for Segmentation of Histopathological Images of Frozen Sections." arXiv e-prints, p. arXiv: 2204.06955, (2022).
32- Olaide N Oyelade, Absalom E Ezugwu, Hein S Venter, Seyedali Mirjalili, and Amir H Gandomi, "Abnormality classification and localization using dual-branch whole-region-based CNN model with histopathological images." Computers in Biology and Medicine, Vol. 149, p. 105943, (2022).
33- H Hu et al., "Breast cancer histopathological images recognition based on two-stage nuclei segmentation strategy." PloS one, Vol. 17 (No. 4), pp. e0266973-e73, (2022).
34- Sushovan Chaudhury, Nilesh Shelke, Kartik Sau, B Prasanalakshmi, and Mohammad Shabaz, "A novel approach to classifying breast cancer histopathology biopsy images using bilateral knowledge distillation and label smoothing regularization." Computational and Mathematical Methods in Medicine, Vol. 2021(2021).
35- Ying Zou, Jianxin Zhang, Shan Huang, and Bin Liu, "Breast cancer histopathological image classification using attention high‐order deep network." International Journal of Imaging Systems and Technology, Vol. 32 (No. 1), pp. 266-79, (2022).
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IssueVol 11 No 3 (2024) QRcode
SectionOriginal Article(s)
DOI https://doi.org/10.18502/fbt.v11i3.15880
Keywords
Deep Learning Breast Cancer Histopathological eXtreme Gradient Boosting Support Vector Machine

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How to Cite
1.
Ayyadurai M, Andiappan N. Implementation of Improved U-Net and Optimized XGBoost-SVM Classifier for Early Detection of Masses and Microcalcifications in Breast. Frontiers Biomed Technol. 2024;11(3):344-360.