Ultrasonographic Assessment of Intima-Media Thickness (IMT), as a Surrogate of Future Atherosclerosis and Cardiac Diseases in Patients with Hashimoto’s Thyroiditis and Concomitant Celiac Disease: A Case-Control Study
-
Maryam Alaei
,
Mohamad Ghazanfari Hashemi
,
Seyedeh Nooshin Miratashi Yazdi
,
Mohammad Ali Kaviani
,
Ali Asadifar
,
Sahand Adib Moradi
,
Khazar Adibmoradi Langaroudi
,
Helia Helali
,
Mina Mahboudi
,
Aynaz Gerami
Abstract
Purpose: Intima-Media Thickness (IMT), which is frequently evaluated by B-mode ultrasound study, has been proved to be a reliable surrogate marker for atherosclerosis progression and a predictor of upcoming cardiovascular risks. Sonographic changes of intima-media thickness of carotid artery in Hashimoto’s thyroiditis and Celiac disease have been investigated separately. In this study we aimed to evaluate the changes in sonographic appearance of the carotid artery and its mural thickness in patients with Hashimoto’s thyroiditis and concomitant Celiac disease, as a surrogate marker of atherosclerosis and a predictor of cardiovascular diseases.
Materials and Methods: A total of 191 patients including 89 patients with only Hashimoto’s thyroiditis, 11 patients with Hashimoto’s thyroiditis and concomitant Celiac disease, and 91 healthy control subjects underwent ultrasound evaluation of intima-media thickness of carotid artery. High resolution B-mode images with a multi-frequency linear probe, were utilized for assessing the IMT.
Results: IMT in the Hashimoto with celiac disease group was 0.72±0.11 and was 0.69±0.09 in the Hashimoto without celiac disease group and was 0.63±0.10 in the control group. IMT showed significant difference between the three groups and was higher in the Hashimoto patients compared to the control group (P-Value=0.039 and 0.028). Moreover, IMT was marginally higher in the Hashimoto patients with celiac disease compared to the Hashimoto patients without celiac disease (P-Value = 0.046).
Conclusion: Patients with Hashimoto’s thyroiditis suffering from concomitant Celiac disease, showed a more increased IMT values compared to other subjects. This can indicate the potential importance and predictive value of ultrasonic IMT evaluation in Celiac disease and Hashimoto’s thyroiditis as a marker of atherosclerosis progression as well as future risk of cardiovascular insults.
2- K. L. Becker, R. H. Ferguson, and Conahey Wm Mc, "The connective-tissue diseases and symptoms associated with Hashimoto's thyroiditis." (in eng), N Engl J Med, Vol. 268pp. 277-80, Feb 7 (1963).
3- B. Głowinska-Olszewska et al., "Does Hashimoto's Thyroiditis Increase the Risk of Cardiovascular Disease in Young Type 1 Diabetic Patients?" (in eng), Front Endocrinol (Lausanne), Vol. 11p. 431, (2020).
4- E. J. Ciaccio, S. K. Lewis, A. B. Biviano, V. Iyer, H. Garan, and P. H. Green, "Cardiovascular involvement in celiac disease." (in eng), World J Cardiol, Vol. 9 (No. 8), pp. 652-66, Aug 26 (2017).
5- Z. M. Gluvic, S. S. Zafirovic, M. M. Obradovic, E. M. Sudar-Milovanovic, M. Rizzo, and E. R. Isenovic, "Hypothyroidism and Risk of Cardiovascular Disease." (in eng), Curr Pharm Des, Vol. 28 (No. 25), pp. 2065-72, (2022).
6- S. A. Paschou et al., "Thyroid disorders and cardiovascular manifestations: an update." (in eng), Endocrine, Vol. 75 (No. 3), pp. 672-83, Mar (2022).
7- N. Milisavljević, M. Cvetković, G. Nikolić, B. Filipović, and N. Milinić, "Dilated cardiomyopathy associated with celiac disease: case report and literature review." (in eng), Srp Arh Celok Lek, Vol. 140 (No. 9-10), pp. 641-3, Sep-Oct (2012).
8- N. K. Goel, R. D. McBane, and P. S. Kamath, "Cardiomyopathy associated with celiac disease." (in eng), Mayo Clin Proc, Vol. 80 (No. 5), pp. 674-6, May (2005).
9- G. M. S. Myrmel, T. Lunde, and S. Saeed, "Clinical spectrum of Celiac disease from a cardiology perspective." (in eng), Pak J Med Sci, Vol. 38 (No. 4Part-II), pp. 782-84, Mar-Apr (2022).
10- Joseph F. Polak and Daniel H. O'Leary, "Carotid Intima-Media Thickness as Surrogate for and Predictor of CVD." Global Heart, Vol. 11 (No. 3), pp. 295-312.e3, 2016/09/01/ (2016).
11- Hashemi Mohamad Ghazanfari et al., "Effects of Idiopathic Restless Leg Syndrome on Intima-media Thickness of Carotid Artery: A Case Control Study." Frontiers in Biomedical Technologies, Vol. 0 (No. 0), 06/11 (2023).
12- G. Losurdo et al., "Serologic diagnosis of celiac disease: May it be suitable for adults?" (in eng), World J Gastroenterol, Vol. 27 (No. 42), pp. 7233-39, Nov 14 (2021).
13- S. K. Lee and P. H. Green, "Endoscopy in celiac disease." (in eng), Curr Opin Gastroenterol, Vol. 21 (No. 5), pp. 589-94, Sep (2005).
14- S. Taghizadeh et al., "Barriers and facilitators of childhood obesity prevention policies: A systematic review and meta-synthesis." (in eng), Front Pediatr, Vol. 10p. 1054133, (2022).
15- Maryam Alaei, Mohamad Ghazanfar Hashemi, Gelayol Chatrnour, and Amirhossein Fakhre Yaseri, "The importance of screening for hypertension in children and adolescents." J Nephropathol.
16- C. Ott and R. E. Schmieder, "Diagnosis and treatment of arterial hypertension 2021." (in eng), Kidney Int, Vol. 101 (No. 1), pp. 36-46, Jan (2022).
17- American Diabetes Association, "2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2021." Diabetes Care, Vol. 44 (No. Supplement_1), pp. S15-S33, (2020).
18- P. J. Touboul et al., "Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011." (in eng), Cerebrovasc Dis, Vol. 34 (No. 4), pp. 290-6, (2012).
19- T. Gotoda et al., "Guidelines for sedation in gastroenterological endoscopy (second edition)." (in eng), Dig Endosc, Vol. 33 (No. 1), pp. 21-53, Jan (2021).
20- G. Oberhuber, "Histopathology of celiac disease." (in eng), Biomed Pharmacother, Vol. 54 (No. 7), pp. 368-72, Aug (2000).
21- B. Lebwohl and A. Rubio-Tapia, "Epidemiology, Presentation, and Diagnosis of Celiac Disease." (in eng), Gastroenterology, Vol. 160 (No. 1), pp. 63-75, Jan (2021).
22- F. S. Fousekis, E. T. Beka, I. V. Mitselos, H. Milionis, and D. K. Christodoulou, "Thromboembolic complications and cardiovascular events associated with celiac disease." (in eng), Ir J Med Sci, Vol. 190 (No. 1), pp. 133-41, Feb (2021).
23- A. M. Papadopoulou, N. Bakogiannis, I. Skrapari, D. Moris, and C. Bakoyiannis, "Thyroid Dysfunction and Atherosclerosis: A Systematic Review." (in eng), In Vivo, Vol. 34 (No. 6), pp. 3127-36, Nov-Dec (2020).
24- M. M. Ciccone et al., "Increased carotid IMT in overweight and obese women affected by Hashimoto's thyroiditis: an adiposity and autoimmune linkage?" (in eng), BMC Cardiovasc Disord, Vol. 10p. 22, May 28 (2010).
25- A. M. Demir, Z. Kuloğlu, A. Yaman, S. Fitöz, G. Nergizoğlu, and A. Kansu, "Carotid intima-media thickness and arterial stiffness as early markers of atherosclerosis in pediatric celiac disease." (in eng), Turk J Pediatr, Vol. 58 (No. 2), pp. 172-79, (2016).
26- O. H. Farahid, N. Khawaja, M. M. Shennak, A. Batieha, M. El-Khateeb, and K. Ajlouni, "Prevalence of coeliac disease among adult patients with autoimmune hypothyroidism in Jordan." (in eng), East Mediterr Health J, Vol. 20 (No. 1), pp. 51-5, Feb 11 (2014).
27- R. Valentino et al., "Prevalence of coeliac disease in patients with thyroid autoimmunity." (in eng), Horm Res, Vol. 51 (No. 3), pp. 124-7, (1999).
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| Issue | Vol 12 No 1 (2025) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/fbt.v12i1.17735 | |
| Keywords | ||
| Ultrasonography Intima-Media Thickness Carotid Artery Hashimoto’s Thyroiditis Celiac Disease | ||
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