Evaluation of Conventional treatment planning techniques for radiotherapy of gastroesophageal junction cancer: a dosimetric comparison between men and women patients
-
Mahdi Ghorbani
,
Mohamad Pursamimi
,
Mehdi Khosravi
,
Ghazal Mehri-Kakavand
,
Wrya Parwaie
,
Seyed Mohammad Hosseini
,
Ali Mohammad Sharifi
,
Meysam Tavakoli
Abstract
Purpose: Gastro-esophageal (GE) junction cancer has an increasing rate in the worldwide. This study compares radiotherapy dosimetric and radiobiological parameters in the target and organs at risk (OARs) in patients with GE junction cancer in both men and women. Materials and methods: Here, thirty patients were selected, for which radiotherapy had been performed with 6-MV photon beam of a linear accelerator (Shinva Medical, Shandong, China). Dosimetric and radiobiological parameters in the planning target volume (PTV) and OARs were compared for all patients using paired-sample t-test. Additionally, field-in-field (FIF), three-field (3F), and four-field box (4FB) planning techniques were also compared for men and women patients. Results: In terms of dose distribution in PTV, there is significant difference between men and women patients in terms of TCP and monitor unit (MU). In terms of dose distribution in OARs, there is also significant difference between men and women in terms of NTCP for right lung, V20Gy for right lung. Conclusions: Generally, most of dosimetric parameters were the same for men and women patients, however, some differences were seen in terms of TCP, MU and some parameters (NTCP, and V20 Gy for right lung). Therefore, it is suggested that more attention be paid when treatment planning is performed for GE junction cancer and the differences between the anatomical differences of men and women be considered.
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12-Allaveisi F, Moghadam AN. Comparison between the four-field box and field-in-field techniques for conformal radiotherapy of the esophagus using dose-volume histograms and normal tissue complication probabilities. Jpn J Radiol;35(6):327-34, 2017.
13-Fu Y, Deng M, Zhou X, Lin Q, Du B, Tian X, et al. Dosimetric effect of beam arrangement for intensity-modulated radiation therapy in the treatment of upper thoracic esophageal carcinoma. Med Dosim;42(1):47-52, 2017.
14-Lin CY, Huang WY, Jen YM, Chen CM, Su YF, Chao HL, et al. Dosimetric and efficiency comparison of high-dose radiotherapy for esophageal cancer: volumetric modulated arc therapy versus fixed-field intensity-modulated radiotherapy. Dis Esophagus;27(6):585-90, 2014.
15-Fawaz ZS, Kazandjian S, Tsui JM, Devic S, Lecavalier-Barsoum M, Vuong T, et al. What is the optimal radiation technique for esophageal cancer? A dosimetric comparison of four techniques. Cureus;10(7):2985, 2018.
16-Incrocci L, Jensen PT. Pelvic radiotherapy and sexual function in men and women.J Sex Med;10:53-64, 2013.
17-De Courcy L, Bezak E, Marcu LG. Gender-dependent radiotherapy: The next step in personalised medicine? Crit Rev Oncol Hematol;147:102881, 2020.
18-Meunier A, Marignol L. The radiotherapy cancer patient: female inclusive, but male dominated. Int J Radiat Biol;96(7):851-6, 2020.
19-Macdonald G, Paltiel C, Olivotto I, Tyldesley S. A comparative analysis of radiotherapy use and patient outcome in males and females with breast cancer. Ann Oncol;16(9):1442-8, 2005.
20-Page B, Han P, Peng L, Cheng Z, Harkness J, Shen C, et al. Gender differences in radiation therapy effects in male and female patients with head and neck cancer. Int J Radiat Oncol Biol Phys;100(5):1400-1, 2018.
21-Laaksomaa M, Kapanen M, Tulijoki T, Peltola S, Hyödynmaa S, Kellokumpu-Lehtinen PL. Evaluation of overall setup accuracy and adequate setup margins in pelvic image-guided radiotherapy: comparison of the male and female patients. Med Dosim;39(1):74-8, 2014.
22-Fuller CD, Nijkamp J, Duppen JC, Rasch CR, Thomas Jr CR, Wang SJ, et al. Prospective randomized double-blind pilot study of site-specific consensus atlas implementation for rectal cancer target volume delineation in the cooperative group setting. Int J Radiat Oncol Biol Phys;79(2):481-9, 2011.
23-Chavaudra J, Bridier A. Definition of volumes in external radiotherapy: ICRU reports 50 and 62. Cancer Radiother;5(5):472-8, 2001.
24-Pursamimi M, Ghorbani M, Parwaie W, Shakeri A, Meigooni AS. Evaluation of field-in-field, three-field, and four-field techniques for treatment planning of radiotherapy of pancreatic J Cancer Res Ther;18(1):190-199, 2022.
25-Gay HA, Niemierko A. A free program for calculating EUD-based NTCP and TCP in external beam radiotherapy. Phys Med;23(3-4):115-25, 2007.
26-Ohtakara K, Hayashi S, Hoshi H. The relation between various conformity indices and the influence of the target coverage difference in prescription isodose surface on these values in intracranial stereotactic radiosurgery. Br J Radiol;85(1014):223-228, 2012.
27-Chen K, Wei J, Ge C, Xia W, Shi Y, Wang H, et al. Application of auto-planning in radiotherapy for breast cancer after breast-conserving surgery. Sci Rep;10(1):1-7, 2020.
28-Wang L, Li C, Meng X, Li C, Sun X, Shang D, et al. Dosimetric and radiobiological comparison of external beam radiotherapy using simultaneous integrated boost technique for esophageal cancer in different location. Front Oncol;9:674, 2019.
29-Ghadimi B, Jabbari N, Karimkhani L, Mostafanezhad K. Field-in-field technique improves the dosimetric outcome of treatment plans compared with the three-dimensional conformal radiation therapy for esophageal cancer radiotherapy. Int J Hematol Oncol;28:79-85, 2018.
30-Baycan D, Karacetin D, Balkanay AY, Barut Y. Field-in-field IMRT versus 3D-CRT of the breast. Cardiac vessels, ipsilateral lung, and contralateral breast absorbed doses in patients with left-sided lumpectomy: a dosimetric comparison. Jpn J Radiol;30(10):819-23, 2012.
31-Sasaoka M, Futami T. Dosimetric evaluation of whole breast radiotherapy using field-in-field technique in early-stage breast cancer. Int J Clin Oncol;16(3):250-6, 2011.
32-Niemierko A. A generalized concept of equivalent uniform dose (EUD). Med Phys;26(6):1100, 1999.
33-Henríquez FC, Castrillón SV. A quality index for equivalent uniform dose. J Med Phys;36(3):126, 2011.
34-Rana S, Cheng C, Zheng Y, Hsi W, Zeidan O, Schreuder N, et al. Dosimetric study of uniform scanning proton therapy planning for prostate cancer patients with a metal hip prosthesis, and comparison with volumetric‐modulated arc therapy. J Appl Clin Med Phys;15(3):335-48, 2014.
35-Shanei A, Amouheidari A, Abedi I, Kazemzadeh A, Jaafari A. Radiobiological comparison of 3D conformal and intensity modulated radiation therapy in the treatment of left-sided breast cancer. Int J Radiat Res;18(2):315-22, 2020.
36-Mesbahi A, Rasouli N, Mohammadzadeh M, Nasiri Motlagh B, Ozan Tekin H. Comparison of radiobiological models for radiation therapy plans of prostate cancer: three-dimensional conformal versus intensity modulated radiation therapy. J Biomed Phys Engin;9(3):267-278, 2019.
37-Erdem H, Koca T, Tunçel N, Korcum AF. Comparison of three dimensional conformal, intensity modulated and hybrid intensity modulated planning techniques for thorasic esophageal cancer. Klinkeri J Med Sci;40(4):443-450, 2020.
2-Hoffmann L, Mortensen H, Shamshad M, Berbee M, Bizzocchi N, Bütof R, et al. Treatment planning comparison in the PROTECT-trial randomising proton versus photon beam therapy in oesophageal cancer: Results from eight European centres. Radiother Oncol;172:32-41, 2022.
3-Chen Y, Hu L, Lin H, Yu H, You J. Serum metabolomic profiling for patients with adenocarcinoma of the esophagogastric junction. Metabolomics;18(5):1-12, 2022.
4-Wang R, Liu S, Chen B, Xi M. Recent advances in combination of immunotherapy and chemoradiotherapy for locally advanced esophageal squamous cell carcinoma. Cancers;14(20):5168, 2022.
5-Mehri-Kakavand G, Pursamimi M, Parwaie W, Ghorbani M, Khosravi M, Hosseini SM, et al. Assessment of field-in-field, 3-field, and 4-field treatment planning methods for radiotherapy of gastro-esophageal junction cancer. J Biomed Phys Eng;12(5):439-54, 2022.
6-Wu AJ, Bosch WR, Chang DT, Hong TS, Jabbour SK, Kleinberg LR, et al. Expert consensus contouring guidelines for intensity modulated radiation therapy in esophageal and gastroesophageal junction cancer. Int J Radiat Oncol Biol Phys;92(4):911-20, 2015.
7-Baskar R, Lee KA, Yeo R, Yeoh KW. Cancer and radiation therapy: current advances and future directions. Int J Med Sci;9(3):193-9, 2012.
8-Chandra A, Guerrero TM, Liu HH, Tucker SL, Liao Z, Wang X, et al. Feasibility of using intensity-modulated radiotherapy to improve lung sparing in treatment planning for distal esophageal cancer. Radiother Oncol;77(3):247-53, 2005.
9-Chen YJ, Liu A, Han C, Tsai PT, Schultheiss TE, Pezner RD, et al. Helical tomotherapy for radiotherapy in esophageal cancer: a preferred plan with better conformal target coverage and more homogeneous dose distribution. Med Dosim;32(3):166-71, 2007.
10-Van Benthuysen L, Hales L, Podgorsak MB. Volumetric modulated arc therapy vs. IMRT for the treatment of distal esophageal cancer. Med Dosim;36(4):404-9, 2011.
11-Vivekanandan N, Sriram P, Kumar SAS, Bhuvaneswari NR, Saranya K. Volumetric modulated arc radiotherapy for esophageal cancer. Med Dosim;37(1):108-113, 2012.
12-Allaveisi F, Moghadam AN. Comparison between the four-field box and field-in-field techniques for conformal radiotherapy of the esophagus using dose-volume histograms and normal tissue complication probabilities. Jpn J Radiol;35(6):327-34, 2017.
13-Fu Y, Deng M, Zhou X, Lin Q, Du B, Tian X, et al. Dosimetric effect of beam arrangement for intensity-modulated radiation therapy in the treatment of upper thoracic esophageal carcinoma. Med Dosim;42(1):47-52, 2017.
14-Lin CY, Huang WY, Jen YM, Chen CM, Su YF, Chao HL, et al. Dosimetric and efficiency comparison of high-dose radiotherapy for esophageal cancer: volumetric modulated arc therapy versus fixed-field intensity-modulated radiotherapy. Dis Esophagus;27(6):585-90, 2014.
15-Fawaz ZS, Kazandjian S, Tsui JM, Devic S, Lecavalier-Barsoum M, Vuong T, et al. What is the optimal radiation technique for esophageal cancer? A dosimetric comparison of four techniques. Cureus;10(7):2985, 2018.
16-Incrocci L, Jensen PT. Pelvic radiotherapy and sexual function in men and women.J Sex Med;10:53-64, 2013.
17-De Courcy L, Bezak E, Marcu LG. Gender-dependent radiotherapy: The next step in personalised medicine? Crit Rev Oncol Hematol;147:102881, 2020.
18-Meunier A, Marignol L. The radiotherapy cancer patient: female inclusive, but male dominated. Int J Radiat Biol;96(7):851-6, 2020.
19-Macdonald G, Paltiel C, Olivotto I, Tyldesley S. A comparative analysis of radiotherapy use and patient outcome in males and females with breast cancer. Ann Oncol;16(9):1442-8, 2005.
20-Page B, Han P, Peng L, Cheng Z, Harkness J, Shen C, et al. Gender differences in radiation therapy effects in male and female patients with head and neck cancer. Int J Radiat Oncol Biol Phys;100(5):1400-1, 2018.
21-Laaksomaa M, Kapanen M, Tulijoki T, Peltola S, Hyödynmaa S, Kellokumpu-Lehtinen PL. Evaluation of overall setup accuracy and adequate setup margins in pelvic image-guided radiotherapy: comparison of the male and female patients. Med Dosim;39(1):74-8, 2014.
22-Fuller CD, Nijkamp J, Duppen JC, Rasch CR, Thomas Jr CR, Wang SJ, et al. Prospective randomized double-blind pilot study of site-specific consensus atlas implementation for rectal cancer target volume delineation in the cooperative group setting. Int J Radiat Oncol Biol Phys;79(2):481-9, 2011.
23-Chavaudra J, Bridier A. Definition of volumes in external radiotherapy: ICRU reports 50 and 62. Cancer Radiother;5(5):472-8, 2001.
24-Pursamimi M, Ghorbani M, Parwaie W, Shakeri A, Meigooni AS. Evaluation of field-in-field, three-field, and four-field techniques for treatment planning of radiotherapy of pancreatic J Cancer Res Ther;18(1):190-199, 2022.
25-Gay HA, Niemierko A. A free program for calculating EUD-based NTCP and TCP in external beam radiotherapy. Phys Med;23(3-4):115-25, 2007.
26-Ohtakara K, Hayashi S, Hoshi H. The relation between various conformity indices and the influence of the target coverage difference in prescription isodose surface on these values in intracranial stereotactic radiosurgery. Br J Radiol;85(1014):223-228, 2012.
27-Chen K, Wei J, Ge C, Xia W, Shi Y, Wang H, et al. Application of auto-planning in radiotherapy for breast cancer after breast-conserving surgery. Sci Rep;10(1):1-7, 2020.
28-Wang L, Li C, Meng X, Li C, Sun X, Shang D, et al. Dosimetric and radiobiological comparison of external beam radiotherapy using simultaneous integrated boost technique for esophageal cancer in different location. Front Oncol;9:674, 2019.
29-Ghadimi B, Jabbari N, Karimkhani L, Mostafanezhad K. Field-in-field technique improves the dosimetric outcome of treatment plans compared with the three-dimensional conformal radiation therapy for esophageal cancer radiotherapy. Int J Hematol Oncol;28:79-85, 2018.
30-Baycan D, Karacetin D, Balkanay AY, Barut Y. Field-in-field IMRT versus 3D-CRT of the breast. Cardiac vessels, ipsilateral lung, and contralateral breast absorbed doses in patients with left-sided lumpectomy: a dosimetric comparison. Jpn J Radiol;30(10):819-23, 2012.
31-Sasaoka M, Futami T. Dosimetric evaluation of whole breast radiotherapy using field-in-field technique in early-stage breast cancer. Int J Clin Oncol;16(3):250-6, 2011.
32-Niemierko A. A generalized concept of equivalent uniform dose (EUD). Med Phys;26(6):1100, 1999.
33-Henríquez FC, Castrillón SV. A quality index for equivalent uniform dose. J Med Phys;36(3):126, 2011.
34-Rana S, Cheng C, Zheng Y, Hsi W, Zeidan O, Schreuder N, et al. Dosimetric study of uniform scanning proton therapy planning for prostate cancer patients with a metal hip prosthesis, and comparison with volumetric‐modulated arc therapy. J Appl Clin Med Phys;15(3):335-48, 2014.
35-Shanei A, Amouheidari A, Abedi I, Kazemzadeh A, Jaafari A. Radiobiological comparison of 3D conformal and intensity modulated radiation therapy in the treatment of left-sided breast cancer. Int J Radiat Res;18(2):315-22, 2020.
36-Mesbahi A, Rasouli N, Mohammadzadeh M, Nasiri Motlagh B, Ozan Tekin H. Comparison of radiobiological models for radiation therapy plans of prostate cancer: three-dimensional conformal versus intensity modulated radiation therapy. J Biomed Phys Engin;9(3):267-278, 2019.
37-Erdem H, Koca T, Tunçel N, Korcum AF. Comparison of three dimensional conformal, intensity modulated and hybrid intensity modulated planning techniques for thorasic esophageal cancer. Klinkeri J Med Sci;40(4):443-450, 2020.
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How to Cite
1.
Ghorbani M, Pursamimi M, Khosravi M, Mehri-Kakavand G, Parwaie W, Hosseini SM, Sharifi AM, Tavakoli M. Evaluation of Conventional treatment planning techniques for radiotherapy of gastroesophageal junction cancer: a dosimetric comparison between men and women patients. Frontiers Biomed Technol. 2024;.
