Rethinking AI in Medical Imaging: Assumptions, Reality, and Reframing; Towards Physician-Centered Agentic Reasoning

Abstract

Medical imaging has served as primary proving ground for clinical AI, yet a decade of intense research has not translated into proportionate bedside impact. We argue that this gap is not primarily a product of insufficient algorithmic performance, inadequate regulation, or lim­ited explainability. Rather, it reflects a structural misalignment, between how AI systems are designed and evaluated, and how clinical decisions are made. This work identifies 8 interconnected dimensions of this misalignment: 1) the dominance of pixel-only models in a multimodal clinical world; 2) the erosion of physician trust through opaque and inflexible systems; 3) the unfulfilled promise of founda­tion models in data-sparse medical domains; 4) the persistent bottleneck of non-shareable under-curated datasets; 5) the gap between validated algorithms and deployable clinical platforms; 6) the slow, unmonitored translation of evidence into routine practice; 7) the risk of AI displacing rather than extending physician judgment; and 8) the failure of prediction-centric AI to generate actionable, agentic clinical guidance. For each dimension, we reframe the problem and propose a path forward, culminating in a vision of physician-centered AI solutions with agentic reasoning that extend, rather than replace, clinical judgment.