The Effect of Total Antioxidant Capacity on Periodontal Diseases among Ionizing Radiation Workers
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Abstract
Purpose: This study aimed to evaluate the effect of total antioxidant capacity on periodontal diseases among ionizing radiation workers. The relationship between oxidative stress and periodontal health in this specific occupational group was assessed to gain insights into potential antioxidant supplementation needs and strategies to promote periodontal well-being.
Materials and Methods: This case-control study was conducted among ionizing radiation workers (CT scan section) and control group participants. Salivary samples were collected from both groups, and total antioxidant capacity was measured using an Enzyme-Linked Immunosorbent Assay (ELISA) kit. Clinical periodontal parameters were also assessed. Statistical analysis was performed using T-tests to compare the results between the groups.
Results: The study group showed a significantly lower total antioxidant capacity (2.534) compared to the control group (3.806) (p = 0.022). Significant differences were observed in plaque index, probing pocket depth, and clinical attachment loss between the groups. These findings suggest a potential association between radiation exposure, decreased antioxidant capacity, and periodontal tissue damage.
Conclusion: Radiographic workers exposed to ionizing radiation had lower antioxidant capacity and higher rates of periodontal diseases. Maintaining adequate antioxidants is crucial for protecting periodontal tissues. Further research should investigate mechanisms and exposure variations.
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23- Philippe Bouchard, Pierre Boutouyrie, Catherine Mattout, and Denis Bourgeois, "Risk assessment for severe clinical attachment loss in an adult population." Journal of periodontology, Vol. 77 (No. 3), pp. 479-89, (2006).
24- Dayanidhi Kumar et al., "Genetic instability in lymphocytes is associated with blood plasma antioxidant levels in health care workers occupationally exposed to ionizing radiation." International journal of toxicology, Vol. 35 (No. 3), pp. 327-35, (2016).
25- Jianfang Gao, Xiaomei Dong, Taixiu Liu, Lilong Zhang, and Lin Ao, "Antioxidant status and cytogenetic damage in hospital workers occupationally exposed to low dose ionizing radiation." Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Vol. 850p. 503152, (2020).
2- Hiroko P Indo et al., "A mitochondrial superoxide theory for oxidative stress diseases and aging." Journal of clinical biochemistry and nutrition, Vol. 56 (No. 1), pp. 1-7, (2015).
3- Omayma AR Abozaid, Fatma SM Moawed, Mostafa A Farrag, and Abdel Aziz A Abdel Aziz, "4-(4-Hydroxy-3-methoxyphenyl)-2-butanone modulates redox signal in gamma-irradiation-induced nephrotoxicity in rats." Free Radical Research, Vol. 51 (No. 11-12), pp. 943-53, (2017).
4- Jianhui Chang et al., "28Si total body irradiation injures bone marrow hematopoietic stem cells via induction of cellular apoptosis." Life sciences in space research, Vol. 13pp. 39-44, (2017).
5- Ahmet Cemil Talmaç and Metin Çalişir, "Antioxidants and Periodontal Diseases." in Gingival Disease-A Professional Approach for Treatment and Prevention: IntechOpen, (2019).
6- Mangaluru Deralakatte, "Salivary antioxidant status following radiotherapy in patients with head and neck cancer." Int J Anat Res, Vol. 7 (No. 3.2), pp. 6793-99, (2019).
7- Shahba' Munther, "The effects of cigarette smoking and exercise on total salivary antioxidant activity." The Saudi Dental Journal, Vol. 31 (No. 1), pp. 31-38, (2018).
8- Karoline Koch, Susannah Havermann, Christian Büchter, and Wim Wätjen, "Caenorhabditis elegans as model system in pharmacology and toxicology: effects of flavonoids on redox-sensitive signalling pathways and ageing." The Scientific World Journal, Vol. 2014(2014).
9- Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, and Jean-Noël Vallée, "Interactions between TGF-β1, canonical WNT/β-catenin pathway and PPAR γ in radiation-induced fibrosis." Oncotarget, Vol. 8 (No. 52), p. 90579, (2017).
10- Ulku Baser, Hikmet Gamsiz-Isik, Emine Cifcibasi, Evin Ademoglu, and Funda Yalcin, "Plasma and salivary total antioxidant capacity in healthy controls compared with aggressive and chronic periodontitis patients." Saudi medical journal, Vol. 36 (No. 7), p. 856, (2015).
11- Lue Sun et al., "Total body irradiation causes a chronic decrease in antioxidant levels." Scientific reports, Vol. 11 (No. 1), p. 6716, (2021).
12- VMLB Deo and ML Bhongade, "Pathogenesis of periodontitis: role of cytokines in host response." Dentistry today, Vol. 29 (No. 9), pp. 60-2, 64, (2010).
13- Jalal Ordoni, Vida Sargazi, Zeinab Yazdi Stoodeh, Yazdan Salimi, and Dariush Askari, "Total Antioxidant Capacity level in Radiation Workers and other Staffs of Hospital in Sistan and Baluchestan Province." Iranian Journal of Medical Physics, Vol. 15 (No. Special Issue-12th. Iranian Congress of Medical Physics), pp. 164-64, (2018).
14- Andrea Ghiselli, Mauro Serafini, Fausta Natella, and Cristina Scaccini, "Total antioxidant capacity as a tool to assess redox status: critical view and experimental data." Free Radical Biology and Medicine, Vol. 29 (No. 11), pp. 1106-14, (2000).
15- Baidaa T Ali and Maha Sh Mahmood, "Assessment of Salivary Total Antioxidants Capacity Levels of Patients with Chronic Periodontitis in Comparison to Healthy Control." Journal of Baghdad College of Dentistry, Vol. 30 (No. 1), pp. 58-62, (2018).
16- WK Leung, LJ Jin, LP Samaranayake, and GKC Chlu, "Subgingival microbiota of shallow periodontal pockets in individuals after head and neck irradiation." Oral microbiology and immunology, Vol. 13 (No. 1), pp. 1-10, (1998).
17- Zehra ARDIÇ, Tahir Kemal Şahin, UYAR Mehmet, Hasan Küçükkendirci, İbrahim KILINC, and Elif Nur YILDIRIM ÖZTÜRK, "Effects of occupational exposure to ionizing radiation on oxidative stress and inflammatory markers in healthcare workers of a university hospital in Konya, Turkey." Journal of Cellular Neuroscience and Oxidative Stress, Vol. 13 (No. 2), pp. 994-1003, (2021).
18- Jérôme Lacombe et al., "Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity." Radiation Oncology, Vol. 14 (No. 1), pp. 1-11, (2019).
19- Salih Omer Haji and Jian Lateif Hussein, "Biochemical Study on the Impact of Radiation-induced Oxidative Stress on Radiographers in the X-ray and CT-scan Departments." Baghdad Science Journal, Vol. 20 (No. 3), pp. 0676-76, (2023).
20- Ali Akbar Malekirad et al., "Oxidative stress in radiology staff." Environmental toxicology and pharmacology, Vol. 20 (No. 1), pp. 215-18, (2005).
21- Hubert Thierens, Anne Vral, and Leo De Ridder, "A cytogenetic study of radiological workers: effect of age, smoking and radiation burden on the micronucleus frequency." Mutation Research/Environmental Mutagenesis and Related Subjects, Vol. 360 (No. 2), pp. 75-82, (1996).
22- Ghadah N Alhusaini and Ahlam T Mohammed, "Periodontal status and salivary flow rate among diagnostic radiology department workers." Journal of Baghdad College of Dentistry, Vol. 31 (No. 2), pp. 32-35, (2019).
23- Philippe Bouchard, Pierre Boutouyrie, Catherine Mattout, and Denis Bourgeois, "Risk assessment for severe clinical attachment loss in an adult population." Journal of periodontology, Vol. 77 (No. 3), pp. 479-89, (2006).
24- Dayanidhi Kumar et al., "Genetic instability in lymphocytes is associated with blood plasma antioxidant levels in health care workers occupationally exposed to ionizing radiation." International journal of toxicology, Vol. 35 (No. 3), pp. 327-35, (2016).
25- Jianfang Gao, Xiaomei Dong, Taixiu Liu, Lilong Zhang, and Lin Ao, "Antioxidant status and cytogenetic damage in hospital workers occupationally exposed to low dose ionizing radiation." Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Vol. 850p. 503152, (2020).
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| Issue | Vol 11 No 3 (2024) | |
| Section | Original Article(s) | |
| DOI | https://doi.org/10.18502/fbt.v11i3.15890 | |
| Keywords | ||
| Total Antioxidant Capacity Ionizing Radiation Periodontal Diseases Oxidative Stress Radiographic Workers Salivary Samples | ||
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How to Cite
1.
Waleed Khalid S, Taha Mohammed A. The Effect of Total Antioxidant Capacity on Periodontal Diseases among Ionizing Radiation Workers. Frontiers Biomed Technol. 2024;11(3):471-476.
