Investigating the Macular Vasculature Using Optical Coherence Tomography Angiography Following Pan-Retinal Photocoagulation in Diabetic Retinopathy
-
Mohammadreza Ansari Astaneh
,
Nasim Shahsavan Gharbi
,
Mojtaba Abrishami
,
Elham Bakhtiari
,
Mehrdad Motamed Shariati
Abstract
Purpose: This study used Optical Coherence Tomography Angiography (OCTA) to examine the progression of the macular flow profile over the course of a month following Pan-Retinal Photocoagulation (PRP).
Materials and Methods: A total of Thirteen individuals in the earliest stages of Proliferative Diabetic Retinopathy (PDR) were included in this follow-up investigation. This study has excluded patients who have had prior therapy for Diabetic Retinopathy (DR) or any other retinal disease. Before and after PRP treatment, all participants had a comprehensive eye exam and had a macular optical coherence tomography angiography (AngioVue RTVue XR Avanti, Optovue, Fremont, CA, USA, software version: 2018,0,0,18) performed using a 6-by-6-millimeter scan size. Superficial and deep capillary plexus were analyzed.
Results: 13 patients, 6 male (46%) and 7 female (54%), with PDR, participated in this study. The mean± Sd of the patient’s age was 55.25±9.28 years. Foveal Avascular Zone (FAZ), Deep Vessel Density (DVD), macular Superficial Vessel Density (SVD), and area alterations in PDR patients before and after PRP were not statistically significant, according to this study.
Conclusion: Although a reduction in SFVD, DFVD, and FAZ area in the 1st month following PRP was shown. PRP in patients with early PDR stage of diabetic retinopathy did not have a significant effect on the macular vasculature during the first month of treatment.
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18- Ahmed Shawkat Abdelhalim, Mohamed Farouk Sayed Othman Abdelkader, Mohamed Salah El-Din Mahmoud, and Asmaa Anwar Mohamed Mohamed, "Macular vessel density before and after panretinal photocoagulation in patients with proliferative diabetic retinopathy." International journal of retina and vitreous, Vol. 8 (No. 1), p. 21, (2022).
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21- Mehmet Cem Sabaner, Mustafa Dogan, Muberra Akdogan, and Merve Şimşek, "Panretinal laser photocoagulation decreases large foveal avascular zone area in non-proliferative diabetic retinopathy: A prospective OCTA study." Photodiagnosis and photodynamic therapy, Vol. 34p. 102298, (2021).
22- Nicolas Cuenca et al., "Interpretation of OCT and OCTA images from a histological approach: clinical and experimental implications." Progress in retinal and eye research, Vol. 77p. 100828, (2020).
2- Samhitha Gudla, Divya Tenneti, Makrand Pande, and Srinivas M Tipparaju, "Diabetic retinopathy: pathogenesis, treatment, and complications." Drug delivery for the retina and posterior segment disease, pp. 83-94, (2018).
3- Wei Wang and Amy CY Lo, "Diabetic retinopathy: pathophysiology and treatments." International journal of molecular sciences, Vol. 19 (No. 6), p. 1816, (2018).
4- Ayman G Elnahry and Gehad A Elnahry, "Optical Coherence Tomography Angiography of Macular Perfusion Changes after Anti‐VEGF Therapy for Diabetic Macular Edema: A Systematic Review." Journal of Diabetes Research, Vol. 2021 (No. 1), p. 6634637, (2021).
5- Irini Chatziralli et al., "Disentangling the association between retinal non-perfusion and anti-VEGF agents in diabetic retinopathy." Eye, Vol. 36 (No. 4), pp. 692-703, (2022).
6- Ines Lains et al., "Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA)." Progress in retinal and eye research, Vol. 84p. 100951, (2021).
7- Jae Wan Lim, Sang Joon Lee, Jae Yun Sung, Jin-soo Kim, and Ki Yup Nam, "Effect of prophylactic anti-VEGF injections on the prevention of recurrent vitreous hemorrhage in PDR patients after PRP." Scientific Reports, Vol. 12 (No. 1), p. 14484, (2022).
8- Yue Zhao and Rishi P Singh, "The role of anti-vascular endothelial growth factor (anti-VEGF) in the management of proliferative diabetic retinopathy." Drugs in context, Vol. 7(2018).
9- Beatrice Tombolini, Enrico Borrelli, Riccardo Sacconi, Francesco Bandello, and Giuseppe Querques, "Diabetic macular ischemia." Acta Diabetologica, Vol. 59 (No. 6), pp. 751-59, (2022).
10- Zi-Yi Zhu, Yong-An Meng, Bin Yan, and Jing Luo, "Effect of anti-VEGF treatment on nonperfusion areas in ischemic retinopathy." International Journal of Ophthalmology, Vol. 14 (No. 11), p. 1647, (2021).
11- Maryo Cenk Kohen, Sinan Tatlipinar, Alev Cumbul, and Ünal Uslu, "The effects of bevacizumab treatment in a rat model of retinal ischemia and perfusion injury." Molecular vision, Vol. 24p. 239, (2018).
12- Jin-woo Kwon and Jusang Oh, "Aqueous Humor Analyses in Patients with Diabetic Retinopathy Who Had Undergone Panretinal Photocoagulation." Journal of Diabetes Research, Vol. 2022 (No. 1), p. 1897344, (2022).
13- Zizhong Hu et al., "Monitoring intraocular proangiogenic and profibrotic cytokines within 7 days after adjunctive anti‐vascular endothelial growth factor therapy for proliferative diabetic retinopathy." Acta Ophthalmologica, Vol. 100 (No. 3), pp. e726-e36, (2022).
14- Aiko Ito, Yoshio Hirano, Miho Nozaki, Masayuki Ashikari, Kazuhiko Sugitani, and Yuichiro Ogura, "Short pulse laser induces less inflammatory cytokines in the murine retina after laser photocoagulation." Ophthalmic research, Vol. 53 (No. 2), pp. 65-73, (2015).
15- Glyn Chidlow, Malcolm Plunkett, Robert J Casson, and John PM Wood, "Glial cell and inflammatory responses to retinal laser treatment: comparison of a conventional photocoagulator and a novel, 3-nanosecond pulse laser." Investigative ophthalmology & visual science, Vol. 54 (No. 3), pp. 2319-32, (2013).
16- Massimo Lorusso et al., "Panretinal photocoagulation does not change macular perfusion in eyes with proliferative diabetic retinopathy." Ophthalmic Surgery, Lasers and Imaging Retina, Vol. 50 (No. 3), pp. 174-78, (2019).
17- Hooshang Faghihi et al., "Effect of panretinal photocoagulation on macular vasculature using optical coherence tomography angiography." European Journal of Ophthalmology, Vol. 31 (No. 4), pp. 1877-84, (2021).
18- Ahmed Shawkat Abdelhalim, Mohamed Farouk Sayed Othman Abdelkader, Mohamed Salah El-Din Mahmoud, and Asmaa Anwar Mohamed Mohamed, "Macular vessel density before and after panretinal photocoagulation in patients with proliferative diabetic retinopathy." International journal of retina and vitreous, Vol. 8 (No. 1), p. 21, (2022).
19- Dawei Yang et al., "Macular capillary perfusion in Chinese patients with diabetic retinopathy obtained with optical coherence tomography angiography." Ophthalmic Surgery, Lasers and Imaging Retina, Vol. 50 (No. 4), pp. e88-e95, (2019).
20- Sunniva Kruse Johannesen, Julie Nilssen Viken, Anna Stage Vergmann, and Jakob Grauslund, "Optical coherence tomography angiography and microvascular changes in diabetic retinopathy: a systematic review." Acta Ophthalmologica, Vol. 97 (No. 1), pp. 7-14, (2019).
21- Mehmet Cem Sabaner, Mustafa Dogan, Muberra Akdogan, and Merve Şimşek, "Panretinal laser photocoagulation decreases large foveal avascular zone area in non-proliferative diabetic retinopathy: A prospective OCTA study." Photodiagnosis and photodynamic therapy, Vol. 34p. 102298, (2021).
22- Nicolas Cuenca et al., "Interpretation of OCT and OCTA images from a histological approach: clinical and experimental implications." Progress in retinal and eye research, Vol. 77p. 100828, (2020).
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How to Cite
1.
Ansari Astaneh M, Shahsavan Gharbi N, Abrishami M, Bakhtiari E, Motamed Shariati M. Investigating the Macular Vasculature Using Optical Coherence Tomography Angiography Following Pan-Retinal Photocoagulation in Diabetic Retinopathy. Frontiers Biomed Technol. 2025;.
