The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study
-
Saade Abdalkareem Jasim
,
Bashar Mudhaffar Abdullah
,
Patricio Yánez-Moretta
,
Wesam R. Kadhum
,
Yasser Fakri Mustafa
,
Enas R. Alwaily
,
Munther Abosoda
,
Ali Alsalamy
,
Sada Ghalib Al-Musawi
,
Alaa A. Omran
Abstract
Purpose: Plantago Major (PM) is widely used for the treatment of different diseases due to several active compounds. Previous studies demonstrated the treatment effect of this plant on lung cancer cell lines. Here, we introduced a patient having lung cancer proved by Computed Tomography (CT) and pathological findings. The treatment effect of PM was assessed and presented based on CT and laboratory examinations for this patient as a first human case study.
Materials and Methods: A 64-year-old woman, with gastrointestinal bleeding as well as high Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP) levels, was examined by the chest CT scan for suspicious lung cancer. Pathological findings confirmed the non-small cell lung cancer (adenocarcinoma, stage IIA). The patient consumed 150 ml of PM seeds extract (3-4 times daily) orally for about 4 months. Follow-up CT and laboratory examinations were performed after the treatment period to assess the effect of PM.
Results: The volume of the tumor was reduced by about 62% (based on CT imaging findings) after the treatment with PM. In addition, the laboratory examinations illustrate that ESR and CRP levels reduced remarkably (from 97 mm/h to 24 mm/h for ESR; from 36.8 mg/L to 1.2 mg/L for CRP) after the treatment.
Conclusion: Based on our human study, PM, as a natural compound with antioxidant, anti-inflammatory, and antibiotic characteristics, could have an anti-proliferative effect on non-small cell lung cancer. However, more follow-up examinations on big sample sizes are needed to assess the treatment effect of PM.
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19. Ansari L, Banaei A, Dastranj L, Majdaeen M, Vafapour H, Zamani H, et al, "Evaluating the radioprotective effect of single dose and daily oral consumption of green tea, grape seed, and coffee bean extracts against gamma irradiation". Applied Radiation and Isotopes. Vol. 174, p. 109781, (2021).
20. Nadi S, Banaei A, Mozdarani H, Monfared AS, Ataei GR, Abedi-Firouzjah R, "Evaluating the radioprotective effect of arbutin on mice exposed to megavoltage X-rays based on hematological parameters and lymphocytes micronucleus assay". Int J Radiat Res. Vol. 18(No. 2), pp. 275–82, (2020).
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22. Galvez M, Martın-Cordero C, Lopez-Lazaro M, Cortes F, and Ayuso MJ, "Cytotoxic effect of Plantago spp. on cancer cell lines". Journal of Ethnopharmacology. Vol. 88(No. 2–3), pp. 125–130, (2003).
23. Oto G, Ekin S, Ozdemir H, Levent A, and Berber I, "The effect of Plantago major Linnaeus on serum total sialic acid, lipid-bound sialic acid, some trace elements and minerals after administration of 7, 12-dimethylbenz (a) anthracene in rats". Toxicology and Industrial Health. Vol. 28(No. 4), pp. 334–342, (2012).
24. Velasco-Lezama R, Tapia-Aguilar R, Román-Ramos R, Vega-Avila E, and Pérez-Gutiérrez MS, "Effect of Plantago major on cell proliferation in vitro". Journal of Ethnopharmacology. Vol. 103(No. 1), pp. 36–42, (2006).
25. Farid A, Sheibani M, Shojaii A, Noori M, and Motevalian M, "Evaluation of anti-inflammatory effects of leaf and seed extracts of Plantago major on acetic acid-induced ulcerative colitis in rats". Journal of Ethnopharmacology. Vol. 298, p. 115595, (2022).
2. Türel I, Özbek H, Erten R, Öner AC, Cengiz N, Yilmaz O, "Hepatoprotective and anti-inflammatory activities of Plantago major L". Indian Journal of Pharmacology. Vo. 41(No. 3), pp. 120-8, (2009).
3. Stenholm Å, Göransson U, Bohlin L, "Bioassay‐guided Supercritical Fluid Extraction of Cyclooxygenase‐2 Inhibiting Substances in Plantago major L". Phytochemical Analysis. Vo. 24(No. 2), pp. 176–83, (2013).
4. Beara IN, Orčić DZ, Lesjak MM, Mimica-Dukić NM, Peković BA, Popović MR, "Liquid chromatography/tandem mass spectrometry study of anti-inflammatory activity of Plantain (Plantago L.) species". Journal of Pharmaceutical and Biomedical Analysis. Vo. 52(No. 5), pp. 701–6, (2010).
5. Rahamooz-Haghighi S, Bagheri K, Danafar H, and Sharafi A, "Anti-proliferative properties, biocompatibility, and chemical composition of different extracts of Plantago major medicinal plant". Iranian Biomedical Journal. Vol. 25(No. 2), p. 106, (2021).
6. Najafian Y, Hamedi SS, Farshchi MK, and Feyzabadi Z, "Plantago major in Traditional Persian Medicine and modern phytotherapy: a narrative review". Electronic Physician. Vol. 10(No. 2), p. 6390, (2018).
7. Wang H, Zhao C, Huang Y, Wang F, Li Y, and Chung HY, "Chemical constituents and bioactivities of plantaginis herba". Hong Kong Medicinal Journal. Vol. 22, pp. 29–35, (2015).
8. Kolak U, BOĞA M, URUŞAK EA, Ulubelen A, "Constituents of Plantago major subsp. intermedia with antioxidant and anticholinesterase capacities". Turkish Journal of Chemistry. Vol. 35(No. 4), pp. 637–45, (2011).
9. Rasoulian B, Rashidipour M, Chehelcheraghi F, Moradi Rad N, Moeni M, Shafie F, et al, "The Wound Healing Effect of Plantago Major Leaf Extract in a Rat Model: Pilot Experimental Confirmation of a Traditional Belief in Persian Medicine". Herbal Medicines Journal. Vol. 3(No. 1), pp. 26–30, (2018).
10. Ruffa MJ, Ferraro G, Wagner ML, Calcagno ML, Campos RH, Cavallaro L, "Cytotoxic effect of Argentine medicinal plant extracts on human hepatocellular carcinoma cell line". Journal of ethnopharmacology. Vol. 79(No. 3), pp. 335–9, (2002).
11. Nazarizadeh A, Mikaili P, Moloudizargari M, Aghajanshakeri S, Javaherypour S, "Therapeutic uses and pharmacological properties of Plantago major L. and its active constituents". J Basic Appl Sci Res. Vol. 3(No. 9), pp. 212–21, (2013).
12. Adom MB, Taher M, Mutalabisin MF, Amri MS, Kudos MBA, Sulaiman MWAW, et al, "Chemical constituents and medical benefits of Plantago major". Biomedicine & Pharmacotherapy. Vol. 96, pp. 348–60, (2017).
13. Rasoulian B, Rashidipour M, Chehelcheraghi F, Moradi Rad N, Moeni M, Shafie F, et al, "The Wound Healing Effect of Plantago Major Leaf Extract in a Rat Model: Pilot Experimental Confirmation of a Traditional Belief in Persian Medicine". Herbal Medicines Journal. Vol. 3(No. 1), pp. 26–30, (2018).
14. Kartini K, Wati N, Gustav R, Wahyuni R, Anggada YF, Hidayani R, et al, "Wound healing effects of Plantago major extract and its chemical compounds in hyperglycemic rats". Food Bioscience. Vol. 41, p. 100937, (2021).
15. Mahmood MM, Mahdi AK, "Experimental study of the effect of Plantago major leaves extract on contaminated excisional wound healing in rabbits". Iraqi Journal of Veterinary Sciences. Vol. 36(Supplement I), pp. 31–9, (2022).
16. Salehi Z, Tavakoli A, Hamedi SH, Samimi S, Namjooyan F, Ansari M, et al, "Efficacy of Plantago major leaf extract cream compared to placebo in preventing acute radiodermatitis in breast cancer patients: A randomized clinical trial". European Journal of Integrative Medicine. Vol. 62, p. 102284, (2023).
17. Adom MB, Taher M, Mutalabisin MF, Amri MS, Kudos MBA, Sulaiman MWAW, et al, "Chemical constituents and medical benefits of Plantago major". Biomedicine & Pharmacotherapy. Vol. 96, pp. 348–360, (2017).
18. Majdaeen M, Banaei A, Abedi-Firouzjah R, Gorji KE, Ataei G, Momeni F, et al. Investigating the radioprotective effect of sesamol oral consumption against gamma irradiation in mice by micronucleus and alkaline comet assays. Applied Radiation and Isotopes.Vol. 159, p. 109091, (2020).
19. Ansari L, Banaei A, Dastranj L, Majdaeen M, Vafapour H, Zamani H, et al, "Evaluating the radioprotective effect of single dose and daily oral consumption of green tea, grape seed, and coffee bean extracts against gamma irradiation". Applied Radiation and Isotopes. Vol. 174, p. 109781, (2021).
20. Nadi S, Banaei A, Mozdarani H, Monfared AS, Ataei GR, Abedi-Firouzjah R, "Evaluating the radioprotective effect of arbutin on mice exposed to megavoltage X-rays based on hematological parameters and lymphocytes micronucleus assay". Int J Radiat Res. Vol. 18(No. 2), pp. 275–82, (2020).
21. Rahgoshai S, Mehnati P, Aghamiri MR, Borujeini MH, Banaei A, Tarighatnia A, et al, "Evaluating the radioprotective effect of Cimetidine, IMOD, and hybrid radioprotectors agents: an in-vitro study". Applied Radiation and Isotopes. Vol.174, p. 109760, (2021).
22. Galvez M, Martın-Cordero C, Lopez-Lazaro M, Cortes F, and Ayuso MJ, "Cytotoxic effect of Plantago spp. on cancer cell lines". Journal of Ethnopharmacology. Vol. 88(No. 2–3), pp. 125–130, (2003).
23. Oto G, Ekin S, Ozdemir H, Levent A, and Berber I, "The effect of Plantago major Linnaeus on serum total sialic acid, lipid-bound sialic acid, some trace elements and minerals after administration of 7, 12-dimethylbenz (a) anthracene in rats". Toxicology and Industrial Health. Vol. 28(No. 4), pp. 334–342, (2012).
24. Velasco-Lezama R, Tapia-Aguilar R, Román-Ramos R, Vega-Avila E, and Pérez-Gutiérrez MS, "Effect of Plantago major on cell proliferation in vitro". Journal of Ethnopharmacology. Vol. 103(No. 1), pp. 36–42, (2006).
25. Farid A, Sheibani M, Shojaii A, Noori M, and Motevalian M, "Evaluation of anti-inflammatory effects of leaf and seed extracts of Plantago major on acetic acid-induced ulcerative colitis in rats". Journal of Ethnopharmacology. Vol. 298, p. 115595, (2022).
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| Non-Small Cell Lung Cancer Plantago Major Computed Tomography | ||
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How to Cite
1.
Abdalkareem Jasim S, Mudhaffar Abdullah B, Yánez-Moretta P, R. Kadhum W, Fakri Mustafa Y, R. Alwaily E, Abosoda M, Alsalamy A, Ghalib Al-Musawi S, A. Omran A. The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study. Frontiers Biomed Technol. 2023;.
